A5044127294- Nanopore and Nanochannel Transport Studies
- Advanced biosensing and bioanalysis techniques
- Magnetic and transport properties of perovskites and related materials
- Microfluidic and Capillary Electrophoresis Applications
- Electrostatics and Colloid Interactions
- Advanced Condensed Matter Physics
- RNA Interference and Gene Delivery
- Advanced Biosensing Techniques and Applications
- Fuel Cells and Related Materials
- Microfluidic and Bio-sensing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Ion-surface interactions and analysis
- Physics of Superconductivity and Magnetism
- Magnetic properties of thin films
- nanoparticles nucleation surface interactions
- Force Microscopy Techniques and Applications
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Atomic and Subatomic Physics Research
- Electronic and Structural Properties of Oxides
- Experimental and Theoretical Physics Studies
- Nanomaterials and Printing Technologies
- Thermal Radiation and Cooling Technologies
- Orbital Angular Momentum in Optics
- Pancreatic function and diabetes
University of Toronto
2013-2023
University of Ottawa
2019-2023
Saint-Vincent Hospital
2022
St. Michael's Hospital
2013
Ionic substitution forms an essential pathway to manipulate the carrier density and crystalline symmetry of materials via ion-lattice-electron coupling, leading a rich spectrum electronic states in strongly correlated systems. Using ferromagnetic metal SrRuO3 as model system, we demonstrate efficient reversible control both through ionic liquid gating induced protonation. The insertion protons electron-dopes SrRuO3, exotic paramagnetic phase transition along with increase proton...
Single-molecule counting is the most accurate and precise method for determining concentration of a biomarker in solution leading to emergence digital diagnostic platforms enabling precision medicine. In principle, solid-state nanopores-fully electronic sensors with single-molecule sensitivity-are well suited task. Here we present immunoassay scheme capable reliably quantifying target protein complex biofluids that overcomes specificity, sensitivity, consistency challenges associated use...
The capture and translocation characteristics of multi-arm DNA star nanostructures are studied to evaluate their potential as advanced labels for improved solid-state nanopore sensing performance.
We study the magneto-optical Kerr effect (MOKE) in SrRuO$_3$ thin films, uncovering wide regimes of wavelength, temperature, and magnetic field where rotation is not simply proportional to magnetization but instead displays two-component behavior. One component MOKE signal tracks average magnetization, while second "anomalous" bears a resemblance anomalies Hall resistivity which have been previously reported skyrmion materials. present theory showing that arise from non-monotonic relation...
Characterization of DNA nanostructures using solid-state nanopores: Single-file and folded translocations give insights on polymer dimensions rigidity.
Abstract The ability to digitally count single molecules enables accurate and precise determination of the concentration a disease biomarker. Owing their intrinsic single-molecule sensitivity fully electronic detection capability, solid-state nanopores show great promise for this task toward point-of-care diagnostic applications. Here, we describe protocols implementing magnetic bead-based immunoassay strategy coupled with digital downstream nanopore electrical readout. scheme employs DNA...
Inspired by its central role in many biological processes, the transport of biopolymers across nanoscale pores is at heart a single-molecule sensing technology aimed nucleic acid and protein sequencing, as well biomarker detection. When electrophoretically driven through pore an electric potential gradient, translocating polymer hinders flow ions, producing transient current blockage signature that can be mapped to physicochemical properties polymer. Although investigated theoretically...
Due to their programmability via specific base pairing, self-assembled DNA origami structures have proven be useful for a wide variety of applications, including diagnostics, molecular computation, drug delivery, and therapeutics. Measuring characterizing these is therefore great interest an important part quality control. Here, we show the extent which nanostructures can characterized by solid-state nanopore; non-destructive, label-free, single-molecule sensor capable electrically detecting...
While notable progress has been made in recent years both experimentally and theoretically understanding the highly complex dynamics of polymer capture transport through nanopores, there remains significant disagreement between experimental observation theoretical prediction that needs to be resolved. Asymmetric salt concentrations, where concentrations ions on each side membrane are different, can used enhance rates prolong translocation times polymers translocating a nanopore from low...
Traditional enzyme-linked immunosorbent assay (ELISA), long the workhorse for specific target protein detection using microplate wells, is nearing its fundamental limit of sensitivity. New opportunities in health care call vitro diagnostic tests with ultrahigh Magnetic bead-based sandwich immunoassay formats have been developed that can reach unprecedented sensitivities, orders magnitude better than are allowed by rate constants a single ligand-receptor interaction. However, these...
Measuring the resistivity of high-purity single crystals ${\mathrm{Sr}}_{3}{\mathrm{Ru}}_{2}{\mathrm{O}}_{7}$ under pressure, we find strong evidence that field-induced spin density wave phase at $H\ensuremath{\parallel}c$ metamagnetic transition is suppressed a surprisingly low pressure $\ensuremath{\sim}3\ifmmode\pm\else\textpm\fi{}1$ kbar. This offers possibility studying bare quasi-two-dimensional quantum critical point, testing $T\ensuremath{\rightarrow}0$ K limit theories Planckian...
Perfect optical vortex (POV) is a type of beam with an infinite thin ring and fixed radius independent its topological charge. Here we propose the concept generalized perfect along arbitrary curves beyond regular shapes circle ellipse. Generalized vortices also share similar properties as POVs, such defined only owning charges scales. Notably, they naturally degenerate to POVs elliptic circles ellipses, respectively. We experimentally generated through digital micromirror device (DMD)...
While notable progress has been made in recent years both experimentally and theoretically understanding the highly complex dynamics of polymer capture transport through nanopores, there remains significant disagreement between experimental observation theoretical prediction that needs to be resolved. Asymmetric salt concentrations, where concentrations ions on each side membrane are different, can used enhance rates prolong translocation times electrophoretically driven polymers...
Traditional ELISA, long the workhorse for specific target protein detection using microplate wells, is nearing its fundamen-tal limit of sensitivity. New opportunities in healthcare call vitro diagnostic tests with ultra-high Magnetic bead-based ELISA formats have been developed that can reach unprecedented sensitivities order magnitude better than are allowed by rate constants a single ligand-receptor interaction. However, these sensitivity assays highly vulnerable to host confounding...
While notable progress has been made in recent years both experimentally and theoretically understanding the highly complex dynamics of polymer capture transport through nanopores, there remains significant disagreement between experimental observation theoretical prediction that needs to be resolved. Asymmetric salt concentrations, where concentrations ions on each side membrane are different, can used enhance rates prolong translocation times polymers translocating a nanopore from low...
Traditional ELISA, long the workhorse for specific target protein detection using microplate wells, is nearing its fundamen-tal limit of sensitivity. New opportunities in healthcare call vitro diagnostic tests with ultra-high Magnetic bead-based ELISA formats have been developed that can reach unprecedented sensitivities order magnitude better than are allowed by rate constants a single ligand-receptor interaction. However, these sensitivity assays highly vulnerable to host confounding...