A5009380677- Phosphodiesterase function and regulation
- Radiopharmaceutical Chemistry and Applications
- Neuroendocrine Tumor Research Advances
- Nitric Oxide and Endothelin Effects
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Medical Imaging Techniques and Applications
- Synthesis and Catalytic Reactions
- Receptor Mechanisms and Signaling
- Neuroethics, Human Enhancement, Biomedical Innovations
- Ion channel regulation and function
- Enzyme function and inhibition
- Mast cells and histamine
- Hemoglobin structure and function
University of Saskatchewan
2018-2019
KU Leuven
2010-2016
Objectives 68Ga–Dotatoc has become the PET radiopharmaceutical of choice for diagnosis and treatment follow-up neuroendocrine tumours. is prepared on-site through a so-called magisterial preparation. The use an appropriate buffer during radiolabelling step essential to maximize labelling yield specific activity. Such should be nontoxic, able in pH range 3.5–5.0, not compete with gallium ions preferentially have weak metal complexing capacity avoid formation colloidal gallium. In addition,...
Epidermal growth factor receptor (EGFR) upregulation is associated with enhanced proliferation and drug resistance in a number of cancers. Nimotuzumab humanized monoclonal antibody high affinity for EGFR. The objective this study was to determine if 89Zr-DFO-nimotuzumab could be suitable human use as PET probe quantifying EGFR vivo.To evaluate the pharmacokinetics, biodistribution, microPET imaging, radiation dosimetry, normal tissue toxicity tumor non-tumor bearing mice...
Epidermal growth factor receptor I (EGFR) is overexpressed in most cancers of epithelial origin. Antibody drug conjugates (ADCs) with PEGylated-maytansine (PEG-DM1) show promise vitro and vivo. However, vivo biodistribution data for ADCs PEG-DM1 have not been reported. Development methods to understand the real-time behavior these needed move compounds clinic. <b>Methods:</b> Here we used noninvasive small-animal SPECT/CT imaging ex PEG<sub>6</sub>-DM1 ADCs. We developed nimotuzumab...
Insulin growth factor receptor (IGF-1R) is overexpressed in many cancers of epithelial origin, where it confers enhanced proliferation and resistance to therapies targeted at other receptors. Anti-IGF-1R monoclonal antibodies have not demonstrated significant improvements patient outcomes clinical trials. Humanized antibody cixutumumab (IMC-A12) binds IGF-1R with low nM affinity. In this study, was conjugated p-SCN-Bn-DOTA radiolabeled 111In or 225Ac for imaging radiotherapy using a...
The cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5) plays an important role in various pathologies including pulmonary arterial hypertension and cardiomyopathy. PDE5 represents therapeutic and/or prognostic target, but noninvasive assessment of expression is lacking. purpose this study was to develop evaluate pyridopyrazinone derivatives labeled with carbon-11 or fluorine-18 as PDE5-specific PET tracers. In biodistribution studies, highest retention observed...
Abstract Background To date, few PET tracers for in vivo labeling of red blood cells (RBCs) are available. In this study, we report the radiosynthesis and vitro evaluation 11 C 18 F sulfonamide derivatives targeting carbonic anhydrase II (CA II), a metallo-enzyme expressed RBCs, as potential pool tracers. A proof-of-concept imaging study was performed to demonstrate feasibility assess cardiac function volumes using electrocardiogram (ECG)-gated positron emission tomography (PET) acquisition...