This study reports on the production of chitosan fibers and 3-D fiber meshes for use as tissue engineering scaffolds. Both structures were produced by means a wet spinning technique. Maximum strain at break tensile strength developed found to be 8.5% 204.9 MPa, respectively. After 14 d immersion in simulated body fluid (SBF), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), inductively coupled plasma emission (ICP) analyses showed that bioactive Ca-P layer was formed...

Abstract Recent advances in tissue engineering and regenerative medicine fields can offer alternative solutions to the existing techniques for cartilage repair. In this context, a variety of materials has been proposed, injectable hydrogels are among most promising alternatives. The aim work is explore ability poly( N ‐isopropylacrylamide)‐ g ‐methylcellulose (PNIPAAm‐ ‐MC) thermoreversible hydrogel as three‐dimensional support cell encapsulation toward regeneration articular through...

Mimicking the structural organization and biologic function of natural extracellular matrix has been one main goals tissue engineering. Nevertheless, majority scaffolding materials for bone regeneration highlights biochemical functionality in detriment mechanical properties. In this work we present a rather innovative construct that combines same structure electrospun type I collagen nanofibers with starch-based microfibers. These combined structures were obtained by two-step methodology...

Abstract This study proposes a new route for producing fiber mesh scaffolds from starch–polycaprolactone (SPCL) blend. It was demonstrated that the with 77% porosity could be obtained by simple wet‐spinning technique based on solution/precipitation of polymeric To enhance cell attachment and proliferation, Ar plasma treatment applied to scaffolds. observed surface morphology chemical composition were significantly changed because etching functionalization surfaces. XPS analyses showed an...

Biodegradable composite membranes containing propolis were produced from PCL/PLLA blends using a simple and low-cost solvent casting method, subsequently their physicochemical, mechanical, antibacterial properties characterized. SEM analysis revealed that the addition of has created honeycomb-like structures on film surfaces. The flexibility films increased in presence propolis, which may provide ease use during application. Propolis disrupted organized structure both polymers at molecular...

Synthetic polymers remain to be a major choice for scaffold fabrication due their structural stability and mechanical strength. However, the lack of functional moieties limits application cell-based therapies which necessitate modification functionalization. Blending synthetic with natural components is simple effective way achieve desired biological properties scaffold. Herein, nanofibrous mats made polycaprolactone (PCL) egg white protein (EWP) blend were developed further evaluated use as...

During tendon injuries, the sheath is also damaged. This study aims to test effectiveness of engineered synovial cell biomembrane on prevention adhesions. Forty New Zealand Rabbits enrolled into four groups. Engineered was produced by culturing suspension fabricated collagen matrix membrane. Study groups were: repair (group A), zone covered with plane (Group B), injection over C), and application D). Biomechanical evaluations excursion, metacarpophalangeal proximal interphalangeal joints...

Several therapeutic approaches have been developed to promote bone regeneration, including guided regeneration (GBR), where barrier membranes play a crucial role in segregating soft tissue and facilitating growth. This study emphasizes the importance of considering specific requirements design materials for with focus on development double-layered membrane mimic both hard tissues within context GBR. The tissue-facing layer comprises collagen zinc-doped bioactive glass support while combines...

In this study, a bilayered collagen-based membrane was prepared to mimic skin structure as potential candidate for wound dressing application. To achieve the desired similar skin, freeze-drying and electrospinning methods were used consecutively. The macroporous sublayer by of collagen intended absorption exudates, while upper layer electrospun onto freeze-dried part an impermeable microorganisms. Nanofiber loaded with silver nanoparticles antibacterial activity. order improve biostability,...

Tissue engineering using scaffolds and growth factors is a crucial approach in bone regeneration repair. The combination of bioactive agents carrying microparticles with porous can be an efficient solution when controlled release bio-signalling molecules required. present study was based on recent biodegradable scaffold protein-loaded produced innovative manner which protein loss minimized during the loading process. Bovine serum albumin (BSA)-loaded gelatin were obtained by grinding...

Poly-L-lactic acid (PLLA) electrospun nanofiber scaffold is one of the most commonly used synthetic polymer scaffolds for bone tissue engineering application. However, PLLA hydrophobic in nature, hence does not maintain proper cell adhesion and formation, moreover, it cannot provide osteo-inductive environment due to inappropriate surface characteristic lack motives participating first cellular events. To modify these shortcomings different approaches have been used, among those coating with...

Microchannel-patterned starch–poly(capro-lactone)/hydydroxyapatite (SPCL–HA) and starch–poly(lactic acid) (SPLA) composite membranes were produced for use as a laminated tissue-engineering scaffold that incorporates both physical biochemical patterns. For this purpose, SPCL (30% starch) blended with inorganic hydroxyl apatite (50%) SPLA (50% made compressive moulding. Consequently, the microchannel structures (width 102 µm, 174 µm intervals) developed on by means of micro-patterned metal...

The main innovation of this study is to design a bilayered scaffold which mimics the basic structural assembles natural skin as well carries particular functions stimulate healing severely damaged caused by trauma or serious burn. To mimic physical structure tissue, silk fibroin sponges with large pores were prepared freeze-drying method dermis-like bottom layer. Heparin was then successfully immobilized layer accelerate wound process. Silver sulphadiazine (AgSD), added uppermost scaffolds,...