Margo A. Peyton

ORCID: 0000-0002-7685-3224
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About
Contact & Profiles
Research Areas
  • Ion Channels and Receptors
  • Innovations in Medical Education
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Reflective Practices in Education
  • Parkinson's Disease Mechanisms and Treatments
  • Medical History and Research
  • HER2/EGFR in Cancer Research
  • Cerebrospinal fluid and hydrocephalus
  • Ethics in medical practice
  • Ion channel regulation and function
  • Neurosurgical Procedures and Complications
  • Learning Styles and Cognitive Differences
  • BRCA gene mutations in cancer
  • Radiation Dose and Imaging
  • Hearing, Cochlea, Tinnitus, Genetics
  • Chronic Myeloid Leukemia Treatments
  • Problem and Project Based Learning
  • Disaster Response and Management
  • Monoclonal and Polyclonal Antibodies Research
  • Muscle Physiology and Disorders
  • Neuroscience and Neuropharmacology Research
  • Cell Adhesion Molecules Research
  • Sleep and related disorders
  • Sepsis Diagnosis and Treatment
  • Palliative Care and End-of-Life Issues

Brigham and Women's Hospital
2023-2025

Mass General Brigham
2023-2024

Wake Forest University
2023

Johns Hopkins University
2020-2023

Massachusetts General Hospital
2023

Johns Hopkins Medicine
2020-2022

Georgetown University Medical Center
2017-2019

Georgetown University
2017-2019

Parkinson's Foundation
2017

Foundation Center
2017

Nilotinib is a broad-based tyrosine kinase inhibitor with the highest affinity to inhibit Abelson (c-Abl) and discoidin domain receptors (DDR1/2). Preclinical evidence indicates that reduces level of brain alpha-synuclein attenuates inflammation in models Parkinson's disease (PD). We previously showed penetrates blood-brain barrier (BBB) potentially improves clinical outcomes individuals PD dementia Lewy bodies (DLB). performed physiologically based population pharmacokinetic/pharmacodynamic...

10.1002/prp2.470 article EN cc-by Pharmacology Research & Perspectives 2019-03-12

Distinct dominant mutations in the calcium-permeable ion channel TRPV4 (transient receptor potential vanilloid 4) typically cause nonoverlapping diseases of either neuromuscular or skeletal systems. However, accumulating evidence suggests that some patients develop mixed phenotypes include elements both and disease. We sought to define genetic clinical features these patients.We report a 2-year-old with novel R616G mutation severe neuropathy phenotype bilateral vocal cord paralysis....

10.1002/acn3.51523 article EN Annals of Clinical and Translational Neurology 2022-02-16

Dominant missense mutations of the calcium-permeable cation channel TRPV4 cause Charcot-Marie-Tooth disease (CMT) type 2C and two forms distal spinal muscular atrophy. These conditions are collectively referred to as TRPV4-related neuromuscular share features motor greater than sensory dysfunction frequent vocal fold weakness. Pathogenic variants lead gain ion function that can be rescued by antagonists in cellular animal models. As small molecule have proven safe trials for other...

10.1093/brain/awae201 article EN Brain 2024-06-25

The Accreditation Council for Graduate Medical Education and the Association of American Colleges' commitment to competency-based medical education (CBME) has shifted landscape. methods conducive CBME are learner-centered give educators opportunity develop a more personalized approach curricular development delivery. By understanding learning preferences, better positioned respond changing needs students. Learning Preference Inventory (LPI) is validated tool that assesses preferences across...

10.1212/ne9.0000000000200102 article EN cc-by Neurology Education 2023-12-01

<h3>Objective:</h3> To describe the learning preferences of medical students in Neurology clerkship and to evaluate how correlate with satisfaction curricular elements. <h3>Background:</h3> The rise recorded lectures, problem-based learning, remote has shifted education landscape. By understanding preferences, educators are better positioned respond changing needs students. Learning Preference Inventory (LPI) is a validated tool that assesses across 3 domains: (1) content delivery (concrete...

10.1212/wnl.0000000000201865 article EN Neurology 2023-04-25

When a resident wakes in the night to find her fiancé having seizure, two roles become blurred. How do we travel safely between bedsides our homes and hospital?

10.1056/nejmp2311767 article EN New England Journal of Medicine 2024-03-09

Objectives We present a case of cortical laminar necrosis after severe hydrocephalus to highlight considerations for multimodal cerebral autoregulation monitoring determine mean arterial pressure (MAP) thresholds during neurological emergencies, as well postoperative head imaging patients with ventriculoperitoneal shunts (VPS). Methods A 40-year-old woman history Chiari II malformation and non-communicating VPS presented in septic shock from sacral wound. One week colostomy fecal diversion,...

10.1177/19418744241242504 article EN The Neurohospitalist 2024-03-29

The Pediatric Emergency Care Applied Research Network (PECARN) Head Injury/Trauma Algorithm is a well-validated decision rule used to identify patients at low risk of clinically important traumatic brain injuries who may not need head CT. In adult with mild trauma, elevated serum glucose and white cell count (WCC) have been associated abnormal CT findings. Currently, or WCC considered in pediatric patients. objective this study was determine if elevations could be as additional tools...

10.1136/jim-2020-001509 article EN Journal of Investigative Medicine 2020-12-23

In this narrative medicine essay, a medical student learns of her inherited disease during genetics class in which she sees an image foot that matches own, DNA missense stemming from biological father who left life when was infant.

10.1001/jama.2021.5484 article EN JAMA 2021-05-04

<h3>Objective:</h3> Clinical trials for transient receptor potential vanilloid 4 (TRPV4)-associated neuromuscular disease have been limited by the lack of natural history data and clearly defined endpoints to assess treatment response. We sought characterize TRPV4-associated through a standardized patient questionnaire neurologic exam. <h3>Background:</h3> Mutations in TRPV4 cause spectrum disease, including Charcot-Marie-Tooth type 2C related forms spinal muscular atrophy. Case reports...

10.1212/wnl.0000000000203288 article EN Neurology 2023-04-25
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