Nik Marzuki Sidik

ORCID: 0000-0002-7687-0358
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About
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Research Areas
  • Microbial Natural Products and Biosynthesis
  • CRISPR and Genetic Engineering
  • Biotechnology and Related Fields
  • Genetically Modified Organisms Research
  • Mycobacterium research and diagnosis
  • Animal Genetics and Reproduction
  • Pluripotent Stem Cells Research
  • Biomedical Ethics and Regulation
  • Insect Resistance and Genetics
  • Plant tissue culture and regeneration
  • Medicinal Plant Research
  • Tuberculosis Research and Epidemiology
  • Plant-Microbe Interactions and Immunity
  • Biomedical and Engineering Education
  • Cancer therapeutics and mechanisms
  • Aquaculture Nutrition and Growth
  • Marine Sponges and Natural Products
  • Plant Genetic and Mutation Studies
  • Synthesis and Biological Evaluation
  • Plant Pathogens and Fungal Diseases
  • Plant Physiology and Cultivation Studies
  • Diagnosis and treatment of tuberculosis
  • Plant Stress Responses and Tolerance
  • Mollusks and Parasites Studies
  • Leaf Properties and Growth Measurement

Universiti Malaysia Kelantan
2017-2024

National University of Malaysia
2004-2016

University of Strathclyde
2016

Government of Malaysia
2005

Malaysian Agricultural Research and Development Institute
2005

National Institutes of Biotechnology Malaysia
2005

Universiti Sains Malaysia
2005

Three novel endophytic streptomycetes have been isolated and characterized from plants with ethnobotanical uses on the Malay Peninsula including: Thottea grandiflora (family -Aristolochiaceae), Polyalthia spp. -Annonaceae), Mapania sp. -Cyperaceae). Each isolate, as studied by scanning electron microscopy, has small hyphae, produces typical barrel-shaped spores arising hyphal fragmentation. Interestingly, although none any detectable antibacterial killing properties, each demonstrable...

10.1111/j.1574-6968.2007.00819.x article EN FEMS Microbiology Letters 2007-06-30

Isolation and characterization of cyclo-(tryptophanyl-prolyl) chloramphenicol from Streptomyces sp. SUK 25 with antimethicillin-resistant Staphylococcus aureus activity Muhanna M Alshaibani,1 Juriyati Jalil,2 Nik Sidik,3 Ruangelie Edrada-Ebel,4 Noraziah Zin1 1Programme Biomedical Science, School Diagnostic Applied Health Sciences, Faculty 2Drug Herbal Research Centre, Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, 3School Bioscience Biotechnology, Science Technology, Bangi,...

10.2147/dddt.s101212 article EN cc-by-nc Drug Design Development and Therapy 2016-05-01

Transgenic papaya plants were regenerated from hypocotyls and immature zygotic embryo after cocultivation with Agrobacterium tumefaciens LBA-4404 carrying a binary plasmid vector system containing neomycin phosphotransferase (nptII) gene as the selectable marker β-glucuronidase (GUS) reporter gene. The explants co-cultivated on regeneration medium 500 mg/L carbenicillin + 200 cefotaxime for one week. cocultivated transferred into final selection 50 kanamycin callus induction well plant...

10.1155/2013/235487 article EN cc-by International Journal of Genomics 2013-01-01

Xanthone is an organic compound mostly found in mangosteen pericarp and widely known for its anti-proliferating effect on cancer cells. In this study, we evaluated the effects of xanthone crude extract (XCE) α-mangostin (α-MG) normoxic hypoxic human hepatocellular carcinoma (HepG2) cells their toxicity towards zebrafish embryos. XCE was isolated using a mixture acetone water (80:20) verified via high performance liquid chromatography (HPLC). Both α-MG showed higher anti-proliferation HepG2...

10.3390/toxics6040060 article EN cc-by Toxics 2018-10-09

Cadmium (Cd) contamination of urban and agricultural soils is toxic to humans, animals may cause negative effects on plant growth crop production. The existing conventional methods are found be not efficient remove Cd from contaminated soil. present experiment reports the analysis nine T1 lines transgenic tobacco carrying metallothionein gene (eiMT1) Eleusine indica, with potential for high efficiency remediate in soils. Thirty-days old plants were treated different concentrations CdNO3 (0,...

10.21475/ajcs.19.13.04.p1630 article EN Australian Journal of Crop Science 2019-04-20

Pomacea sp. is a freshwater gastropod that capable of withstanding oxidative stress during extreme environmental changes. The snail enzymatic responses have already been elucidated through biochemical, transcriptomics, and proteomics analysis. However, their non-enzymatic yet to be elucidated. Therefore, this study aims characterize the antioxidant activity identify compounds from maculata. To address aims, polar non-polar extraction snail-whole body extract was conducted using methanol...

10.55230/mabjournal.v49i5.1643 article EN Malaysian Applied Biology 2020-12-31

This article reviews the literature related to main idea of study, rooting from definition biotechnology, global status commercialized biotechnology products, and local public attitudes towards modern past models for attitude biotechnology. The first section review will be in-depth-discussion regarding according several established international organizations, followed by products which emphasize on how is classified area are being focused more stakeholders, based previous studies. Last but...

10.5897/ajb.9000427 article EN AFRICAN JOURNAL OF BIOTECHNOLOGY 2011-09-03

Nowadays, the rapid development of biotechnology has become a main concern for larger part world. It one most promising fields which guarantee returns to businesses and offers benefits society. When dealing with biotechnology, first issue that comes mind is safeness technology from tip toe, is, products how they can be used on human beings animal, their effects environment. The objective this paper assess needs adequacy regulation in developing countries compared developed countries. In...

10.5897/ajb.9000493 article EN AFRICAN JOURNAL OF BIOTECHNOLOGY 2011-09-03

The aim of this study was to compare the efficiency two transformation vectors: binary and super vector in process gene transfer expression oil palm tissues. Two vectors, namely pFA2 (binary vector, ~24.4 kb) pFA3 (super ~39.4 that contains four essential genes (bktB, phaB, phaC tdcB) produce polyhydroxyvalerate have been successfully constructed. vectors pMR505, which used as a control were later transformed into tissues mediated by Agrobacterium tumefaciens. Oil immature embryos...

10.3923/ajps.2008.526.535 article EN Asian Journal of Plant Sciences 2008-08-01

The issue of using stem cells derived from human embryos and adult tissues to treat diseases has been divisively debated mainly due ethical concerns. objective this article was assess compare the attitude level Malaysian public in Klang Valley region towards (hASCs) embryonic (hESCs). Results survey on 509 respondents revealed that expressed higher support for hASCs, perceived application as having lower moral concern more acceptable by their religion compared hESCs. Univariate analysis...

10.17576/akad-2016-8602-09 article EN cc-by Akademika 2016-10-29

Risk assessment is a procedure normally carried out prior to decision-making on the release of genetically modified organisms (GMOs) into environment. Most countries dealing with GMOs have appropriate guidelines. The objectives this paper are critically examine risk provisions Malaysian Biosafety Act (2007), and compare it several in Cartagena Protocol, as well regulations developed countries. There inadequacies (2007 Act), compared those found European Commission Directives. Although...

10.5897/ajb.9000443 article EN AFRICAN JOURNAL OF BIOTECHNOLOGY 2011-09-03

The present study aims to characterize and predict models for antibacterial activity of a novel oligosaccharide from Streptomyces californics against Erwinia carotovora subsp. using an adaptive neuro-fuzzy inference system artificial neural network. mathematical predication were used determine the optimal conditions produce relationship between factors (pH, temperature, time). characteristics purified agent determined ultraviolet spectroscopy (UV/Vis), infrared (FT-IR), nuclear magnetic...

10.3390/molecules27082384 article EN cc-by Molecules 2022-04-07
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