A5100647660- Multiple Sclerosis Research Studies
- Pneumonia and Respiratory Infections
- Parkinson's Disease Mechanisms and Treatments
- Mycobacterium research and diagnosis
- Cancer Treatment and Pharmacology
- Balance, Gait, and Falls Prevention
- Advanced Breast Cancer Therapies
- Tuberculosis Research and Epidemiology
- Respiratory viral infections research
- Pneumocystis jirovecii pneumonia detection and treatment
- HER2/EGFR in Cancer Research
- Laser-Ablation Synthesis of Nanoparticles
- Ocular Surface and Contact Lens
- Botulinum Toxin and Related Neurological Disorders
- Advanced Drug Delivery Systems
- Acute Lymphoblastic Leukemia research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neutropenia and Cancer Infections
- Lung Cancer Research Studies
- Hemoglobin structure and function
- Lung Cancer Treatments and Mutations
- Transcranial Magnetic Stimulation Studies
- Lysosomal Storage Disorders Research
- Fungal Infections and Studies
- Osteoarthritis Treatment and Mechanisms
Fujian Provincial Cancer Hospital
2022-2024
Tianjin Huanhu Hospital
2021-2024
Fujian Medical University
2020-2023
Fujian Provincial Hospital
2022-2023
Harvard University
2022
Biogen (United States)
2018-2022
Massachusetts General Hospital
2022
Shandong Provincial Hospital
2022
Shandong First Medical University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
The intrathecally administered antisense oligonucleotide tofersen reduces synthesis of the superoxide dismutase 1 (SOD1) protein and is being studied in patients with amyotrophic lateral sclerosis (ALS) associated mutations SOD1 (SOD1 ALS).
Objective: From December 2019, the new coronavirus pneumonia (COVID-19) broke out in Wuhan, Hubei, and spread rapidly to nationwide. On January 20, 2020, National Health Committee classified COVID-19 as one of B class infectious diseases treated it A disease. During epidemic period, routine diagnosis treatment tumor patients was affected with varying degrees. In this special we performed superiority multi-disciplinary team treatment, achieved accurate hepatobiliary malignant tumors, provided...
To the Editor: Community-acquired pneumonia (CAP) in adults refers to inflammation of lung parenchyma involving alveolar wall. It occurs community environment (outside hospital), including caused by pathogens with definite latency after admission. CAP is still main burden medical and health resources. With use broad-spectrum antimicrobial agents, aging population, emergence new pathogens, pathogen spectrum has changed. In addition traditional methods microbiological cultivation immunology...
Introduction. Postural instability is commonly observed in Parkinson’s disease, leading to an increasing risk of falling and worsening as the disease progresses. We found that limit stability can be applied reflect dynamic evolution postural patients with Parkinson's disease. Methods. Forty-three (9 Hoehn Yahr stage I, 12 II, 14 III, 8 IV) met criteria for diagnosis idiopathic could stand independently at least 10 minutes. Twelve healthy controls no sign parkinsonism were also recruited. was...
Deep brain stimulation (DBS) has shown a remarkably high effectiveness for Parkinson's disease (PD). In many PD patients during DBS surgery, the therapeutic effects of test are estimated by assessing changes in bradykinesia as voltage is increased. this study, we evaluated potential leap motion controller (LMC) to quantify motor component could make intraoperative assessment more accurate. Seven participants with idiopathic receiving chronic bilateral subthalamic nucleus deep therapy were...
Abstract Background To explore the efficacy of postoperative antifungal treatment for preventing recurrence pulmonary cryptococcosis (PC) and occurrence cryptococcal meningitis (CM), a retrospective study was conducted in 112 hospitalized PC patients with or without following surgery. Methods The failure rate, CM incidence were compared. Additionally, effectiveness therapy assessed by gathering analyzing published literature. Results rate (P = .054) .178) similar 2 groups, but lower group...
Objective: To compare real-world effectiveness of delayed-release dimethyl fumarate (DMF) with fingolimod (FTY) in relapsing-remitting multiple sclerosis (RRMS) patients. Background: In comparative studies RRMS patients, including claims data and registries, treatment DMF compared FTY for up to 2 years was associated no statistically significant differences relapse. Design/Methods: EFFECT (NCT02776072), a retrospective, multicenter, international, single-timepoint medical record review...
e13127 Background: Apatinib is an oral, highly potent tyrosine-kinase inhibitor targeting VEGFR2. Preclinical studies have demonstrated that apatinib can enhance the anti-tumor effect of taxanes in TNBC via promoting apoptosis and suppressing migration invasion tumor cells. Previous also shown role combination with chemotherapy for treating TNBC. However, combinational treatment nab-paclitaxel metastatic has not been reported. Therefore, objective this study was to evaluate safety efficacy...
e13065 Background: Fulvestrant is used after aromatase inhibitor (AI) failure in metastatic breast cancer but resistance develops quickly. We hypothesized that using anlotinib, a novel multi-target tyrosine kinase inhibitor, may delay fulvestrant patients (pts) and thus improve its efficacy. This single-arm, phase II trial aims to evaluate the efficacy safety of combined regimen pts with HR-positive HER2-negative, previously AI treated, locally advanced or cancer. Methods: The key enrolled...
The management of breast cancer patients in the current COVID-19 outbreak is challenging. Myelosuppression associated with treatment may increase risk infection both hospitals and at home. We implemented following strategy to reduce myelosuppression adjuvant chemotherapy during pandemic: (1) changing original regimen AC×4→wT×12 wT×12→AC×4. (2) substitution standard paclitaxel nanoparticle albumin-bound (nab)-paclitaxel (nab-paclitaxel). For 43 who completed nab-paclitaxel treatment,...
Sodium Hyaluronate and Inflammatory Cytokine Levels in Synovial FluidThis study evaluated the efficacy of intraarticular injection sodium hyaluronate treatment knee osteoarthritis its influence on levels stromal cell-derived factor-1 matrix metalloproteinases 3, 9 13 synovial fluid patients with osteoarthritis.A total 180 treated orthopaedic outpatient department Hubei Provincial Hospital from April 2015 to 2017 were selected as research objects all them given extracted before injection, 1 3...
ABSTRACT Ophthalmic disease treatment remains a significant problem globally, resulting in poor vision and blindness. UV irradiation bacterial infection may cause severe damage to the corneal, leading loss within few days. Corneal neovascular abnormally growth that bock lights reach eyes, causes low vision. Thus it requires urgent efficient clinical treatment. Contact lenses play an essential role treating ophthalmic issues. In this work, we synthesized chitosan-stabilized Au nanoparticles...
Abstract BACKGROUND: This study aimed to compare the clinical characteristics of infections caused by different pathogens and then establish a viral/bacterial infection prediction model guide early identification in inpatients with community-acquired pneumonia (CAP). METHODS: A total 687 patients who were diagnosed CAP our hospital between March 2012 December 2018 studied. Basic data, symptoms, laboratory examinations, imaging examinations collected, virus/bacteria equation was established....
From the beginning of 20th century, Alois Alzheimer, a German doctor, discovered Alzheimer′s disease, so far, disease-related research has been focus researchers all over world. Alzheimer's disease to mild cognitive impairment, then subjective attention phase is also being advanced. Subjective as stage earlier than important implications for early diagnosis and intervention disease.This article will summarize progress conception screening instruments impairment at home abroad. Key...
April 27, 2018April 10, 2018Free AccessReal-world Effectiveness of Delayed-release Dimethyl Fumarate in Relapsing-remitting Multiple Sclerosis Patients Who Are Treatment-naïve or Treated With Only One Prior Therapy: Final Results from the EFFECT Study (P6.373)Jonathan Calkwood, Stanley Cohan, Andrew Chan, Ellen Lathi, Anneke Van Der Walt, Fan Wu, Jinny Min, and Catherine TaylorAuthors Info & AffiliationsApril 2018 issue90 (15_supplement)https://doi.org/10.1212/WNL.90.15_supplement.P6.373...
April 22, 2018April 10, 2018Free AccessEfficacy of Delayed-Release Dimethyl Fumarate in Newly Diagnosed and Other Early Multiple Sclerosis Patients, Patients Switching from Interferon or Glatiramer Acetate, Routine Medical Practice: Interim Results ESTEEM (P1.367)Kathryn Giles, Jerome Hanna, Fan Wu, Catherine Taylor, Konstantin Balashov, Richard Macdonell, Joerg Windsheimer, Nicholas EverageAuthors Info & AffiliationsApril 2018 issue90...
To assure and improve the quality safety of care provided by dialysis facilities, federal oversight has been conducted through periodic survey assessment. However, with growing number individuals living ESRD state agencies have faced challenges in time resources to complete activities. Therefore, process ('Basic Survey' used prior 2013) was redesigned order develop a more efficient ('Core newly implemented since 2013). The purpose this analysis evaluate compare facility outcomes between Core...
Abstract Background We compared the clinical characteristics of infections caused by different pathogens and established a viral/bacterial infection prediction model to guide early identification among inpatients with community-acquired pneumonia (CAP). Methods Data were analysed establish for treatment bacterial or viral infections. Basic data, symptoms, laboratory examinations, imaging patients collected compared, virus/bacteria equation was established. Results The proportion muscle...