A5059558997- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Advanced X-ray Imaging Techniques
- Digital Radiography and Breast Imaging
- Advanced MRI Techniques and Applications
- Particle Detector Development and Performance
- Radiation Dose and Imaging
- X-ray Spectroscopy and Fluorescence Analysis
- Radiomics and Machine Learning in Medical Imaging
- Advanced Neuroimaging Techniques and Applications
- CCD and CMOS Imaging Sensors
- Advanced Radiotherapy Techniques
- Functional Brain Connectivity Studies
- Liver Disease Diagnosis and Treatment
- MRI in cancer diagnosis
- Advanced Electron Microscopy Techniques and Applications
- Advanced NMR Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Advances in Oncology and Radiotherapy
- Multiple Sclerosis Research Studies
- Laser-Plasma Interactions and Diagnostics
- Advanced Semiconductor Detectors and Materials
- Motor Control and Adaptation
- Nuclear Physics and Applications
- Dementia and Cognitive Impairment Research
Ospedale dei Bambini Vittore Buzzi
2025
University of Trieste
2015-2024
Istituto Nazionale di Fisica Nucleare, Sezione di Trieste
2015-2024
Istituto Nazionale di Fisica Nucleare
2009-2022
Elettra-Sincrotrone Trieste S.C.p.A.
2020-2022
Ospedale Sandro Pertini
2005
Ospedale di Cattinara
1991-2000
Ospedale Vito Fazzi
1995
Abstract To demonstrate that the lipid volume fraction In liver steatosis can be accurately estimated with in vivo hydrogen‐1 magnetic resonance (MR) spectroscopy, authors developed a calibration procedure based on vitro MR spectroscopy of extracts from steatotlc specimens. The fractions determined were compared results histomorphometry and calibrated computed tomographic (CT) data. fat was good agreement CT results, whereas underestimated amount hepatic fat. indicate determination steatotic...
Synchrotron-radiation computed tomography has been applied in many research fields. Here, PITRE (Phase-sensitive X-ray Image processing and Tomography REconstruction) PITRE_BM (PITRE Batch Manager) are presented. supports phase retrieval for propagation-based phase-contrast imaging/tomography (PPCI/PPCT), extracts apparent absorption, refractive scattering information of diffraction enhanced imaging (DEI), allows parallel-beam reconstruction conventional absorption CT data PPCT retrieved...
The authors evaluated the effect on mammographic examinations of use synchrotron radiation to detect phase-perturbation effects, which are higher than absorption effects for soft tissue in energy range 15–25 keV. Detection was possible because high degree coherence sources. Synchrotron images were obtained a phantom and vitro breast specimens compared with conventional studies. On basis grades assigned by three reviewers, image quality former considerably higher, delivered dose fully compatible.
RATIONALE AND OBJECTIVES. The authors evaluated the degree of fatty infiltration liver in subjects with diffuse steatosis using image-guided 1H localized MR spectroscopy and correlated magnetic resonance (MR)-determined fat fraction computed tomography (CT) liver/spleen density ratio histologic evaluation. METHODS. measurements were performed at 1.5 T by applying a double-spin-echo localization sequence. Twenty-six patients underwent CT examinations ultrasound (US)-guided biopsy....
Recently, new imaging modalities based on the detection of weak phase perturbations effects, among which are contrast and diffraction imaging, have been developed by several researchers. Due to their high sensitivity weakly absorbing details, these techniques seem be very promising for applications in medical field. On other hand, digital radiology is undergoing a wide diffusion, its benefits presently well understood. Up now, however, strong pixel size constraints associated with pattern...
To prospectively evaluate the diagnostic contribution of mammography with synchrotron radiation in patients questionable or suspicious breast abnormalities identified at combined digital (DM) and ultrasonography (US).The ethics committee approved this prospective study, written informed consent was obtained from all patients. Mammography performed a phase-detection technique laboratory. Forty-nine women who met least one inclusion criteria (palpable mass, focal asymmetry, architectural...
At the SYnchrotron Radiation for MEdical Physics (SYRMEP) beamline of Elettra Synchrotron Light Laboratory in Trieste (Italy), an extensive research program bio‐medical imaging has been developed since 1997. The core carried out by SYRMEP collaboration concerns use (SR) clinical mammography with aim improving diagnostic performance conventional technique. first protocol patients, started 2006 completed at end 2009 and data analysis is now progress.
The aim of the SYRMA-CT collaboration is to set-up first clinical trial phase-contrast breast CT with synchrotron radiation (SR). In order combine high image quality and low delivered dose a number innovative elements are merged: CdTe single photon counting detector, state-of-the-art reconstruction phase retrieval algorithms. To facilitate an accurate exam optimization, Monte Carlo model was developed for calculation using GEANT4. this study, isotropic spatial resolution (120 μm)3 scans...
The measurement of the linear attenuation coefficients breast tissues is fundamental importance in field x-ray diagnostic imaging. Different groups have evaluated by carrying out direct measurements which specimens were thin and selected as homogeneous possible. Here, we use monochromatic high-intensity synchrotron radiation computed tomography (SR CT) to evaluate surgical energy range from 15 26.5 keV. X-ray detection performed a custom digital silicon micro-strip device, developed...
Breast computed tomography (BCT) is an emerging application of X-ray in radiological practice. A few clinical prototypes are under evaluation hospitals and new systems development aiming at improving spatial contrast resolution reducing delivered dose. At the same time, synchrotron-radiation phase-contrast mammography has been demonstrated to offer substantial advantages when compared with conventional mammography. Elettra, Italian synchrotron radiation facility, a program BCT based on...
Mean glandular dose (MGD) is the main dosimetric quantity in mammography. MGD evaluation obtained by multiplying entrance skin air kerma (ESAK) normalized (DgN) coefficients. While ESAK an empirical quantity, DgN coefficients can only be estimated with Monte Carlo (MC) methods. Thus, a MC parameters benchmark needed for effectively evaluating GEANT4 toolkit suitable medical purposes that offers to users several computational choices. In this work we investigate performances testing...
Detecting breast tissue alterations is essential for cancer diagnosis. However, inherent bidimensionality limits histological procedures' effectiveness in identifying these changes. Our study applies a 3D virtual histology method based on X-ray phase-contrast microtomography (PhC μ CT), performed at synchrotron facility, to investigate samples including different types of lesions, namely intraductal papilloma, micropapillary intracystic carcinoma, and invasive lobular carcinoma. One-to-one...
Phase retrieval is a technique for extracting quantitative phase information from X-ray propagation-based phase-contrast tomography (PPCT).In this paper, the performance of different single distance algorithms will be investigated.The are herein called phase-attenuation duality Born Algorithm (PAD-BA), Rytov (PAD-RA), Modified Bronnikov (PAD-MBA), Paganin algorithm (PAD-PA) and Wu (PAD-WA), respectively.They all based on property weak absorption sample they employ only PPCT data.In...
X-ray phase contrast imaging (XPCi) methods are sensitive to in addition attenuation effects and, therefore, can achieve improved image for weakly attenuating materials, such as often encountered biomedical applications.Several XPCi exist, most of which have already been implemented computed tomographic (CT) modality, thus allowing volumetric imaging.The Edge Illumination (EI) method had, until now, not a CT modality.This article provides indications that quantitative 3D maps an object's and...
The first clinical study of phase-contrast mammography (PCM) with synchrotron radiation was carried out at the Synchrotron Radiation for Medical Physics beamline Elettra facility in Trieste (Italy) 2006-2009. involved 71 patients unresolved breast abnormalities after conventional digital and ultrasonography exams Radiology Department University Hospital. These cases were referred facility, images acquired using a propagation-based imaging technique. To investigate contribution effects to...
X-ray phase imaging has the potential to dramatically improve soft tissue contrast sensitivity, which is a crucial requirement in many diagnostic applications such as breast imaging. In this context, program devoted perform vivo phase-contrast synchrotron radiation computed tomography ongoing at Elettra facility (Trieste, Italy). The used technique propagation-based configuration, requires spatially coherent source and sufficient object-to-detector distance. work effect of distance on image...
The purpose of this work is to provide an evaluation the mean glandular dose (MGD) for breast computed tomography (CT) with synchrotron radiation in axial scanning configuration a partial or total organ volume irradiation, vivo program CT ongoing at ELETTRA facility (Trieste, Italy). A Geant4 Monte Carlo code was implemented, simulating photon irradiation from source energetic range 8 50 keV 1 intervals, evaluate MGD. validated literature data, terms mammographic normalized coefficients...
Abstract In this study we compared the image quality of a synchrotron radiation (SR) breast computed tomography (BCT) system with clinical BCT in terms contrast-to-noise ratio (CNR), signal-to-noise (SNR), noise power spectrum (NPS), spatial resolution and detail visibility. A phantom consisting several slabs breast-adipose equivalent material different embedded targets (i.e., masses, fibers calcifications) was used. Phantom images were acquired using dedicated installed at Radboud...