A5068911478- Single-cell and spatial transcriptomics
- Cell Image Analysis Techniques
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Hippo pathway signaling and YAP/TAZ
C4 Therapeutics (United States)
2025
Broad Institute
2021-2023
University of Illinois Chicago
1978
A primary obstacle in translating genetic associations with disease into therapeutic strategies is elucidating the cellular programs affected by risk variants and effector genes. Here, we introduce LipocyteProfiler, a cardiometabolic-disease-oriented high-content image-based profiling tool that enables evaluation of thousands morphological profiles can be systematically linked to genes relevant cardiometabolic disease. We show LipocyteProfiler allows surveillance diverse generating rich...
The c-MYB (MYB) oncogenic transcription factor is a key regulator of hematopoietic cell differentiation and proliferation. Recurrent genetic lesions dysregulation MYB have been identified in variety cancers, including adenoid cystic carcinoma (ACC), acute myeloid leukemia (AML), colorectal cancer (CRC), others. We describe the mechanism action biological activity REM-422, first-in-class, potent, selective, oral small molecule messenger RNA (mRNA) degrader being developed for treatment ACC...
Summary A primary obstacle in translating genetics and genomics data into therapeutic strategies is elucidating the cellular programs affected by genetic variants genes associated with human diseases. Broadly applicable high-throughput, unbiased assays offer a path to rapidly characterize gene variant function thus illuminate disease mechanisms. Here, we report LipocyteProfiler, an high-content microscopy assay that amenable large-scale morphological profiling of lipid-accumulating cell...
Injection of epinephrine to 250-to 300-g rats (0.3 mg/day for 2 weeks, followed by 0.6 another 3 weeks) progressively increased the serum PTH and CT, whereas administration approximately 40 mg propranolol daily, in drinking water, decreased levels both these hormones comparison control animals. The studies indicate that, similar shortterm effects observed previous studies, long-term modification β-adrenergic stimuli can affect CT secretions.
SUMMARY Genetic variation at the SLC16A11 locus contributes to disproportionate impact of type 2 diabetes (T2D) on Latino populations. We recently demonstrated that T2D risk variants reduce liver expression and function MCT11, monocarboxylate transporter encoded by gene. Here, we show within is primarily localized low oxygen pericentral region, disrupt oxygen-regulated in human hepatocytes. Under physiologic conditions, MCT11 deficiency alters hepatocyte glucose metabolism, resulting...