A5010674468- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Probiotics and Fermented Foods
- Pneumocystis jirovecii pneumonia detection and treatment
- Oral microbiology and periodontitis research
- Oral health in cancer treatment
- Fungal and yeast genetics research
- Bacterial biofilms and quorum sensing
- 3D Printing in Biomedical Research
- Research on Leishmaniasis Studies
- Malaria Research and Control
- Cancer Research and Treatments
- Computational Drug Discovery Methods
- Oral Health Pathology and Treatment
- Cancer Cells and Metastasis
- Cystic Fibrosis Research Advances
Institut Pasteur
2019-2024
Université Paris Cité
2021-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021-2024
Jawaharlal Nehru Centre for Advanced Scientific Research
2015-2019
As part of the human microbiota, fungus Candida albicans colonizes oral cavity and other mucosal surfaces body. Commensalism is tightly controlled by complex interactions host to preclude fungal elimination but also overgrowth invasion, which can result in disease. such, defects antifungal T cell immunity render individuals susceptible thrush due interrupted immunosurveillance mucosa. The factors that promote commensalism ensure persistence C. a fully immunocompetent remain less clear. Using...
The yeast Candida albicans is primarily a commensal of humans that colonizes the mucosal surfaces gastrointestinal and genital tracts. Yet, C. can under certain circumstances undergo shift from commensalism to pathogenicity. This transition governed by fungal factors such as morphological transitions, environmental cues for instance relationships with gut microbiota host immune system. utilizes distinct sets regulatory programs colonize or infect its evade defense systems. Moreover, an...
Histone H3 and its variants regulate gene expression but the latter are absent in most ascomycetous fungi. Here, we report identification of a variant histone H3, which have designated H3VCTG because exclusive presence CTG clade ascomycetes, including Candida albicans, human pathogen. C. albicans grows both as single yeast cells hyphal filaments planktonic mode growth. It also forms three-dimensional biofilm structure host well on catheter materials under suitable conditions. null...
Candida albicans, the most prevalent fungal pathogen in human microbiota can form biofilms on implanted medical devices. These are tolerant to conventional antifungal drugs and host immune system as compared free-floating planktonic cells. Several vitro models of biofilm formation have been used determine C. albicans biofilm-forming process, regulatory networks, their properties. Here, we performed a genome-wide transcript profiling with cells grown YPD medium both condition. Transcript...
Candida albicans is a commensal of the human microbiota that can form biofilms on implanted medical devices. These are tolerant to antifungals and host immune system. To identify novel genes modulating C . biofilm formation, we performed large-scale screen with 2,454 doxycycline-dependent overexpression strains identified 16 whose significantly hampered formation. Among those, ZCF15 ZCF26 paralogs encode transcription factors have orthologs only in biofilm-forming species clade, caused...
Abstract Candida albicans is a commensal of the human microbiota that can form biofilms on implanted medical devices. These are tolerant to antifungals and host immune system. To identify novel genes modulating C. biofilm formation, we performed large-scale screen with 2454 doxycycline-dependent overexpression strains identified 16 whose significantly hampered formation. Among those, ZCF15 ZCF26 paralogs encode transcription factors have orthologs only in biofilm-forming species clade,...
ABSTRACT As part of the human microbiota, fungus Candida albicans colonizes oral cavity and other mucosal surfaces body. Commensalism is tightly controlled by complex interactions host to preclude fungal elimination but also overgrowth invasion, which can result in disease. such, defects antifungal T cell immunity render individuals susceptible thrush due interrupted immunosurveillance mucosa. The factors that promote commensalism ensure persistence C. a fully immunocompetent remain less...