A5061624204- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Immune Response and Inflammation
- Single-cell and spatial transcriptomics
- Metal-Organic Frameworks: Synthesis and Applications
University of California, Irvine
2021-2024
La Jolla Institute for Immunology
2019
Materials are needed to increase the stability and half-life of therapeutic proteins during delivery. These materials should be biocompatible biodegradable. Here, we demonstrate that enzymes immunoproteins can encapsulated inside cyclodextrin based metal-organic frameworks using potassium as metal node. The release profile controlled with solubility linker. activity after is determined catalytic in vitro assays. results show framework-based protein biocomposites a promising class deliver proteins.
SUMMARY PD-1 blockade unleashes the potent antitumor activity of CD8 cells but can also promote immunosuppressive T regulatory (Treg) cells, which may worsen response to immunotherapy. Tumor Treg inhibition is a promising strategy overcome therapeutic resistance; however, mechanisms supporting tumor Tregs during immunotherapy are largely unexplored. Here, we report that increases in mouse models immunogenic tumors, including melanoma, and metastatic melanoma patients. Unexpectedly,...
Abstract Regulatory T (Treg) cells are indispensable for the maintenance of immune tolerance and prevention autoimmunity; however, how Treg retain their homeostasis with suppressive function remains largely unclear. Here we report that deubiquitinase CYLD plays a critical role in cells. Foxp3− specific knockout mice showed severe pulmonary inflammation due to preferential migration into lung increased interleukin-4 (IL-4) production compared control mice, which was reversed by deletion IL-4....