A5085699958- Analytical Chemistry and Chromatography
- Protein purification and stability
- Microfluidic and Capillary Electrophoresis Applications
- Chromatography in Natural Products
- Cannabis and Cannabinoid Research
- Chemistry and Chemical Engineering
- Viral Infectious Diseases and Gene Expression in Insects
- Monoclonal and Polyclonal Antibodies Research
- Metabolomics and Mass Spectrometry Studies
- Crystallization and Solubility Studies
- Advanced Chemical Sensor Technologies
- GABA and Rice Research
- Mesoporous Materials and Catalysis
- Computational Drug Discovery Methods
- Process Optimization and Integration
- Enzyme Catalysis and Immobilization
- Forensic Toxicology and Drug Analysis
- Mass Spectrometry Techniques and Applications
- Cholinesterase and Neurodegenerative Diseases
- Phytochemical and Pharmacological Studies
- Pickering emulsions and particle stabilization
- Bioenergy crop production and management
- Psychedelics and Drug Studies
- Retinal Diseases and Treatments
- Heat and Mass Transfer in Porous Media
University of Ferrara
2018-2024
San Gallicano Hospital
1995
Developing greener synthesis processes is an inescapable necessity to transform the industrial landscape, mainly in pharmaceutical sector, into a long-term, sustainable reality.
Nowadays, environmental problems are drawing the attention of governments and international organisations, which therefore encouraging transition to green industrial processes approaches. In this context, chemists can help indicate a suitable direction. Beside efforts focused on greening synthetic approaches, currently also analytical techniques separations under observation, especially those employing large volumes organic solvents, such as reversed-phase liquid chromatography (RPLC)....
Preparative liquid chromatography in reversed phase conditions (RPLC) is the most common approach adopted downstream processing for purification of therapeutic peptides at industrial level. Due to strict requirements on quality imposed by Regulatory Agencies, routinary methods based use aqueous buffers and acetonitrile (ACN) as organic modifier are commonly used, where ACN practically only available choice peptide derivatives. However, known suffers many shortcomings, such drastic shortage...
Crocin-I, a valuable natural compound found in saffron (Crocus sativus L.), is the most abundant among various crocin structures. Developing cost-effective and scalable purification process to produce high-purity crocin-I of great interest for future investigations into its biological properties potential applications treatment neurological disorders. However purifying through single-column preparative chromatography (batch) poses yield-purity trade-off due structural similarities crocins,...
Food products are important sources of both endogenous and exogenous chiral molecules, whose distribution must be strictly controlled to ensure preserve food quality safety. Indeed, as an example, pesticides often administered racemic mixtures plants, while one enantiomer is active, the other may have unknown effects on human body could potentially pose a danger consumers. Therefore, information about naturally occurring artificially added compounds can help assess traceability. This work...
Naturally occurring cinnamic acid derivatives are a broad family of aromatic carboxylic acids with bioactive properties. Among the derivatives, for instance, ferulic and caffeic acid, which have been widely studied their antioxidant anti-inflammatory These active ingredients mostly poorly soluble in water, greatly limits bioavailability. To increase bioavailability these acids, green esterification protocols can be developed exploiting lipases. In particular, this article reports process...
Until less than 10 years ago, chiral separations were carried out with columns packed 5 or 3 μ m fully porous particles (FPPs). Times to resolve enantiomeric mixtures easily larger 30 min, so. Pushed especially by stringent requirements from medicinal and pharmaceutical industries, during the last field of liquid chromatography has undergone what can be defined a "true revolution". With purpose developing ever faster efficient method separations, indeed, very particle formats, such as...
The retention behavior of small molecules and N-protected amino acids on a zwitterionic teicoplanin chiral stationary phase (CSP), prepared superficially porous particles (SPPs) 2.0 μm particle diameter, has shown that efficiency enantioselectivity, so enantioresolution, dramatically change depending the employed organic modifier. In particular, it was found while methanol permits boost enantioselectivity resolution acids, at cost efficiency, acetonitrile allows for ability to reach...
A gas chromatographic‐mass spectrometric technique is described for the simultaneous determination of sorbates, benzoates and other lipophilic preservatives in foods beverages. The selected ions monitoring (SIM) allowed unambiguous identification compounds under study. This methodology eliminated all kinds interferences from complex food matrices which affect most routinely‐used techniques, HPLC included. very simple time‐saving extraction procedure was therefore employed, since subsequent...
This work reports about a screening of four adsorbents with different polarity employed for the separation main phytocannabinoids contained in Cannabis sativa L., under normal phase liquid chromatography (NPLC). The effect and type interaction mechanisms (namely Si-, CN-, Diol-, NH2-based SPs) on retention has been investigated variety conditions either by using combinations apolar solvents (heptane or hexane) alcohols (ethanol isopropanol). columns have also real cannabis sample. Graphical...
Biopharmaceuticals are subjected to very strict purity requirements be marketed. At the same time, peptides and other biomolecules industrially synthesized through techniques (e.g., solid-phase synthesis) often leading formation of many impurities with molecular characteristics similar target product. Therefore, purification these mixtures via preparative chromatography can challenging. This typically involves ternary or central-cut separations, characterized by chromatograms where central...
Abstract The increasing interest in hemp and cannabis poses new questions about the influence of drying storage conditions on overall aroma cannabinoids profile these products. Cannabis inflorescences are subjected to shortly after harvest then different containers. These steps may cause a process rapid deterioration with consequent changes precious secondary metabolite content, negatively impacting product quality potency. In this context, work, investigation effects freeze vs tray three...