A5059974764- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Cardiac Arrhythmias and Treatments
- ECG Monitoring and Analysis
- Neurological Disease Mechanisms and Treatments
- Cardiac Arrest and Resuscitation
- Neuroscience and Neural Engineering
- Muscle Physiology and Disorders
- Respiratory Support and Mechanisms
- Dermatology and Skin Diseases
- Cardiac pacing and defibrillation studies
- Receptor Mechanisms and Signaling
- Cardiovascular Function and Risk Factors
- Neurological Disorders and Treatments
- IL-33, ST2, and ILC Pathways
- Healthcare Systems and Reforms
- Heat shock proteins research
- Asthma and respiratory diseases
- Thermal Regulation in Medicine
- Liver Disease Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Neurogenetic and Muscular Disorders Research
- Electrochemical Analysis and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic Neurodegenerative Diseases
Guangzhou Medical University
2024
Beijing Institute of Technology
2023-2024
Harbin Institute of Technology
2017-2022
Heilongjiang Institute of Technology
2019
Functional analysis of the L-type calcium channel has shown that CACNA1C R858H mutation associated with severe QT interval prolongation may lead to ventricular fibrillation (VF). This study investigated multiple potential mechanisms by which facilitates and perpetuates VF. The Ten Tusscher-Panfilov (TP06) human cell models incorporating experimental data on kinetic properties channels were integrated into one-dimensional (1D) fiber, 2D sheet 3D investigate pro-arrhythmic effects mutations...
Unintended postoperative hypothermia in infants is associated with increased mortality and morbidity. We noted consistent postoperatively more than 60% of our neonatal intensive care (NICU) babies. Therefore, we set out to determine whether a targeted quality improvement (QI) project could decrease rates infants.
Abstract The presence of fibrosis in heart tissue is strongly correlated with an incidence arrhythmia, which a leading cause sudden cardiac death (SCD). However, it remains incompletely understood how different distributions, sizes and positions fibrotic tissues contribute to arrhythmogenesis. In this study, we designed 4 ventricular models mimicking wave propagation under normal, myocardial infarction (MI), MI random gradient conditions. Simulation results ideal square indicate that...
Myocardial ischemia, injury and infarction (MI) are the three stages of acute coronary syndrome (ACS). In past two decades, a great number studies focused on myocardial ischemia MI individually, showed that occurrence reentrant arrhythmias is often associated with or MI. However, arrhythmogenic mechanisms in tissue various degrees remodeling ischemic heart have not been fully understood. this study, biophysical detailed single-cell models 1a, 1b, were developed to mimic electrophysiological...
Patients with myocardial ischemia and infarction are at increased risk of arrhythmias, which in turn, can exacerbate the overall mortality. Despite observed reduction recurrent arrhythmias through antiarrhythmic drug therapy, precise mechanisms underlying their effectiveness treating ischemic heart disease remain unclear. Moreover, there is a lack specialized drugs designed explicitly for treatment arrhythmia. This study employs an electrophysiological simulation approach to investigate...
Dupilumab inhibiting the signaling of interleukin(IL)-4 and IL-13 was recommended for treatment severe asthma in children ≥ 6 years old according to Global Initiative Asthma (GINA,2024).This study aimed analyse efficacy safety dupilumab paediatric patients with moderate-to-severe comorbid type 2 inflammatory disease a real-world population. We evaluated medical records diseases, such as atopic dermatitis (AD) allergic rhinitis (AR), receiving treatment. Twenty-five (16 boys; mean age, 9.32 ±...
Previous studies have shown that coronary artery occlusion can cause myocardial ischemia, which induce ventricular tachycardia or fibrillation. According to the time sequence, ischemia be divided into different pathological stages: 1a stage (0-15 minutes), 1b (15-45 short-term infarction (MI) (within a few days) and long-term MI weeks). However, give attention antiarrhythmic drugs directly acting on ion channels for treatment of ischemia. The main reason is effective targets in are unclear....
Aims: Sudden cardiac death (SCD) is mainly induced by ventricular arrhythmia, especially among patients with myocardial infarction (MI). Previous studies have shown that tachycardia and fibrillation are thought to be caused re-entrant waves of excitation. Although in heterogeneous tissue, the traditional vulnerable window unidirectional block when bidirectional propagation was initiated could coexist, little based on effects infarcted areas both windows.Methods Results: The electrophysiology...
Aims: Previous studies have shown that the infarction and ischemia of cardiac tissue are strongly correlated with incidence atrial ventricular tachyarrhythmias. However, so far combined effect myocardial on genesis arrhythmias has not been fully understood. Therefore, this study aimed to investigate how coexistence alters excitation wave propagation.Methods: The electrophysiology remodeling under condition was mimicked based experimental data incorporated into TP06 model. Using constructed...
Abstract Myocardial ischemia, injury and infarction (MI) are the three stages of acute coronary syndrome (ACS). In past two decades, a great number studies focused on myocardial ischemia MI individually, showed that occurrence reentrant arrhythmias is often associated with or MI. However, arrhythmogenic mechanisms in tissue various degrees remodeling ischemic heart have not been fully understood. this study, biophysical detailed single-cell models 1a, 1b, were developed to mimic...
Myocardial ischemia and myocardial infarction (MI) are often accompanied by the occurrence of reentrant arrhythmias, which may lead to sudden cardiac death in severe cases. Previous studies show that electrical alternans can occur during MI arrhythmias. However, so far, mechanism is unclear, related study on particularly important. Based single-cell models previously modeled us at three stages: 1a, 1b, MI, was revealed comparing changes levels: single cells, one-dimensional (1D) tissues,...
Cardiovascular obstruction could lead to myocardial ischemia and infarction (MI). MI can be further divided into short-term stage (several days) long-term months) with the development of coronary artery obstruction, electrophysiological characteristics in these two stages vary greatly. At present, there are no relevant studies on effects different infarct areas (size location) initialization maintenance reentrant waves stages. Therefore, this study aims investigate differences vulnerability...