A5030735156- Metabolomics and Mass Spectrometry Studies
- Nutritional Studies and Diet
- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Menstrual Health and Disorders
- Health, Environment, Cognitive Aging
- Cancer, Lipids, and Metabolism
- Genetic diversity and population structure
- Maternal Mental Health During Pregnancy and Postpartum
- Breastfeeding Practices and Influences
- Environmental Justice and Health Disparities
- Environmental DNA in Biodiversity Studies
- Birth, Development, and Health
- Vitamin D Research Studies
- Atmospheric chemistry and aerosols
- Species Distribution and Climate Change
- Renal and Vascular Pathologies
- Infant Development and Preterm Care
- Molecular Biology Techniques and Applications
- Chemical Analysis and Environmental Impact
- Air Quality and Health Impacts
- Renal Transplantation Outcomes and Treatments
- Colorectal Cancer Screening and Detection
- Intestinal and Peritoneal Adhesions
- Stress Responses and Cortisol
National Institute of Environmental Health Sciences
2024
Yale University
2019-2021
Harvard University
2010
A survey on the challenges and concerns invovled with digitizing natural history specimens was circulated to curators, collections managers, administrators in community Spring of 2009, over 200 responses received. The overwhelming barrier a lack funding, based limited number sources, leaving institutions mostly responsible for providing necessary support. uneven digitization landscape leads patchy accumulation records at varying qualities, different priorities, ulitimately influencing data's...
Metabolomics studies of the early-life exposome often use maternal urine specimens to investigate critical developmental windows, including periconceptional period and early pregnancy. During these windows changes in kidney function can impact concentration. This makes accounting for differential urinary dilution across samples challenging. Because there is no consensus on ideal normalization approach metabolomics data, this study’s objective was determine optimal post-analytical untargeted...
Abstract Background Pediatric thyroid diseases have been increasing in recent years. Environmental risk factors such as exposures to chemical contaminants may play a role but are largely unexplored. Archived neonatal dried blood spots (DBS) offer an innovative approach investigate environmental and effects. Objective In this pilot study, we applied new method for quantifying per- polyfluoroalkyl substances (PFAS) 18 archived DBS from babies born California 1985–2018 acquired hormone...
The progress in the discovery and validation of metabolite biomarkers for detection colorectal cancer (CRC) has been hampered by lack reproducibility between study cohorts. majority discovery-phase biomarker studies have used patient blood samples to identify disease-related metabolites, but this pre-validation phase is confounded non-specific disease influences on metabolome. We therefore propose that would greater success higher CRC if was conducted tumor tissues, find metabolites...
Abstract STUDY QUESTION Are urinary phenol concentrations of methylparaben, propylparaben, butylparaben, triclosan, benzophenone-3, 2,4-dichlorophenol or 2,5-dichlorophenol associated with fecundability and early pregnancy loss? SUMMARY ANSWER were an increased odds loss, higher butylparaben triclosan increase in fecundability. WHAT IS KNOWN ALREADY Phenols are chemicals endocrine-disrupting potential found everyday products. Despite plausible mechanisms reproductive toxicity, there...
Background: Parabens, found in everyday items from personal care products to foods, are chemicals with endocrine-disrupting activity, which has been shown influence reproductive function. Objectives: This study investigated whether urinary concentrations of methylparaben, propylparaben, or butylparaben were associated the metabolome during periconceptional period, a critical window for female Changes could provide insights into mechanisms by parabens impact fertility. Methods: Urinary...