The study of combined effects chemicals and their assessment is one among urgent issues hygiene preventive medicine. Chemicals with variable chemical composition that persist in environmental objects produce simultaneous on human health; given that, it a challenge for researchers to assess combinations composition. To identify key areas development improve the methodology addressing it, necessary systematize knowledge as regards studying patterns features toxicity. This review presents most...

Introduction. Non-ferrous metallurgy holds a specific place among various productions that create potential health risks due to environmental pollution. Total emissions from the branch enterprises into ambient air reach three million tons (aluminum, fluorine, nickel, manganese, benzo(a)pyrene, sulfur dioxide and trioxide, hydrocarbon, etc.) per year, which accounts for 18% of total all stationary sources. Implementation etiopathogenetic prevention programs is promising trend in preventing...

Introduction. There is actual development of scientific and methodological support for the formation evidence base negative impact environmental factors on public health. Material methods. The hygienic assessment air quality territory with placement aluminum production without similar sources emissions was carried out, carcinogenic non-carcinogenic health risk estimated, chemical-analytical clinical-laboratory examination 235 children out to study effects influence studied critical organs...

Introduction. Today, it is relevant to use modern critical technologies for identifying and evaluating the negative effects associated with of chemicals at stages pre-nosological changes. This improves efficiency early detection progress in pre-pathological conditions prior onset pronounced functional changes aggravation disease. The molecular diagnostic methods based on genomic, transcriptomic, proteomic analysis one most promising approaches. Aim work an both aspects practical capabilities...

Introduction. The large-scale responsibility of the Federal Service for Supervision in Protection Rights Consumer and Man Wellbeing (Rospotrebnadzor) ensuring sanitary epidemiological well-being population requires improving methods scientific analysis forecasting to optimize management decisions. purpose work is increase reliability hygienic assessments system state regulation control based on a comparative results assessing formalized risk real harm health under influence chemical...

We evaluated the air quality by content of fluorine-containing compounds according to monitoring studies, chemical and analytical determination fluoride ion in urine performed proteomic analysis blood plasma children observation comparison group. The increased was found group relative same indicator reference level conditions poor for hydrofluoride due economic activity aluminum production facilities. concentration is justified as a marker inhalation exposure. A comparative revealed presence...

We evaluated the air quality by content of fluorine-containing compounds according to monitoring studies, chemical and analytical determination fluoride ion in urine performed proteomic analysis blood plasma children observation comparison group. The increased was found group relative same indicator reference level conditions poor for hydrofluoride due economic activity aluminum production facilities. concentration is justified as a marker inhalation exposure. A comparative revealed presence...

Exposure to neurotropic chemicals (benzene, toluene, xylene, aluminum, manganese, nickel, etc.) as a result of environmental pollution can exacerbate unmodifiable (burdened heredity) and modifiable (intrauterine infections during pregnancy, childbirth the first week child's life) damage factors central nervous system. The review considers some aspects development negative effects when exposed benzene, nickel copper. present-day data international national studies devoted study this problem...

Introduction. With the expansion of range applications copper oxide nanoparticles (CuO NPs) in various fields economic activity, risk exposure population and workers to nanomaterials increases. The physicochemical properties NPs, differed from microparticles (MPs) a chemical analogue, may determine development more pronounced negative effects associated with nanomaterials. In this regard, increase effectiveness preventive measures, there is needed research aimed at studying clarifying...

Introduction. The study of the mechanisms external environmental effects chemicals on human body using highly informative proteomic profiling technologies makes it possible to predict development negative at earliest stage their formation. In combination with experimental studies that exclude influence interfering factors, accuracy identifying changes in protein profile increases. Assessing cause-and-effect relationships between exposure and transformation increases effectiveness prognosis...

Bioaccumulation and morphofunctional disorders induced by metal-containing nanoparticles were investigated on the example of potentially hazardous to health nanodispersed manganese nickel oxides under various exposition conditions (particles size 15-29 17-45 nanometers respectively). As a comparison, micro dimensional analogs which particles was 300- 1300- fold bigger used. It established that metalcontaining at intragastric inhalation exposure had higher penetration power low removal...

Introduction: Aluminum oxide nanoparticles (Al2O3 NPs) are widely used in various productions. Simultaneously, many research works report the toxic effects of this nanomaterial. Given that, there is a growing risk negative produced by Al2O3 NPs on public health. Aims: This study aims to investigate as opposed micro-sized chemical analogue under sub-acute inhalation exposure. Materials and Methods: We identified physical properties micro- sized analogue, including size, specific surface area,...

Introduction. The study of the mechanisms occurrence adverse events at molecular level, followed by biological processes cellular, tissue, and organ allows further investigating mechanism toxic action chemicals to predict development effects in humans. purpose is evaluate disturbances signal-transporter pathways metabolic on base quantification identified target proteins under aerogenic exposure aluminum oxide children. Materials methods. Using methods chemical-analytical, statistical,...

Introduction. High prevalence of alimentary diseases remains an acute healthcare issue. This calls for improvement the methodology health risk assessment under exposure to a set determinants associated with unhealthy and unsafe diets achieve optimal management such risk. Investigation cellular-molecular pathways development metabolic disorder in case signal transduction is non-coordinated becoming especially important. The aim this study improve methodological approaches optimizing nutrition...

The study was conducted to identify the effects of elevated concentrations PM2.5 and PM10 particles in air on morphometric parameters erythrocytes children. Two areas with similar geoclimatic conditions but different exposure these were selected. measured using scanning electron microscopy. In-depth investigations 360 children, general clinical indicators whole blood analyzed. Statistical analysis tools Python programming environment used for data analysis, a two-layer neural network...

ИССЛЕДОВАНИЕ МОРФОЛОГИЧЕСКИХ ИЗМЕНЕНИЙ ТКАНЕЙ ВНУТРЕННИХ ОРГАНОВ ЛАБОРАТОРНЫХ ЖИВОТНЫХ ПРИ ВОЗДЕЙСТВИИ НАНОДИСПЕРСНЫХ ОКСИДОВ ПЕРЕХОДНЫХ И ЛЕГКИХ МЕТАЛЛОВ

Alumina refineries are among the leading sources of atmospheric air pollution with a wide range pollutants hazardous to human respiratory organs. It is relevant study and evaluate occurrence risks for development diseases in children living area affected by emission components an alumina refinery. We assessed quality under observation comparison according monitoring observations, risk non-carcinogenic effects from The content chemicals blood urine adequate factors was quantified. structure...