A5101701754- Heat shock proteins research
- Natural Compounds in Disease Treatment
- Viral-associated cancers and disorders
- Liver physiology and pathology
- Physiological and biochemical adaptations
- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Berberine and alkaloids research
- Parasites and Host Interactions
- NF-κB Signaling Pathways
- Flavonoids in Medical Research
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
- Ocular Diseases and Behçet’s Syndrome
- Cytomegalovirus and herpesvirus research
- Insect Pest Control Strategies
- Multiple Myeloma Research and Treatments
- Soft tissue tumors and treatment
- Vector-Borne Animal Diseases
- Pediatric Hepatobiliary Diseases and Treatments
- Acute Myeloid Leukemia Research
- Endoplasmic Reticulum Stress and Disease
- Autoimmune and Inflammatory Disorders Research
- Molecular Biology Techniques and Applications
- Histone Deacetylase Inhibitors Research
Wuhan University
2014-2020
State Key Laboratory of Virology
2018
State Key Laboratory of Rice Biology
2008-2012
Tongren Hospital
2012
Wuhan Third Hospital
2012
Zhejiang University
2008-2012
China National Rice Research Institute
2008
Six heat shock protein ( HSP ) genes from five families in the parasitoid, P teromalus puparum , were evaluated for their response to temperature (−15 ∼ 3°C and 30 42°C 1 h), heavy metals (0.5 5 mM Cd 2+ Cu 24 h 60 starvation (24 h). Compared with other insect s, all conserved motifs are found . they very similar those of recently sequenced ectoparasitoid N asonia vitripennis The temporal gene expression patterns indicated that these six heat‐inducible, which hsp 40 was most inducible....
Epstein-Barr virus (EBV) is widely found in nasopharyngeal carcinoma (NPC) tissue and associated with poor prognosis of patients. EBV nuclear antigen 1 (EBNA1) expressed all NPC tumors plays multiple biological roles both host cells. Triptolide a natural product extracted from Tripterygium shows anti-cancer activities. The goal this work was to illustrate the effect triptolide elucidate novel anti-apoptotic mechanism EBNA1 cells encountered triptolide. In present study, CCK-8 assay used...
Hepatic stellate cells (HSCs) are the main effectors for various types of hepatic fibrosis, including Schistosome-induced fibrosis. Multiple inflammatory cytokines/chemokines, such as transforming growth factor-β1 (TGF-β1), activate HSCs, and contribute to development MicroRNAs regulate gene expression at posttranscriptional level involved in regulation cytokine/chemokine synthesis. In this study, we showed that soluble egg antigen (SEA) stimulation Schistosoma japonicum infection...
The Pphsc70 (heat shock cognate 70) gene was isolated from the endoparasitoid Pteromalus puparum and then characterized. full-length cDNA 2204 base pair (bp) contained a single 1968 bp ORF that encoded polypeptide of 656 amino acids with predicted molecular mass 71.28 kDa. Phylogenetic analysis based on Hsc70 acid sequences fifteen insect species agreed present phylogeny. In addition, genomic DNA confirmed presence three introns located at coding region as well 5'UTR. A significant elevation...
Kaposi's sarcoma-associated herpesvirus (KSHV) can establish a life-long persistence in the host after primary infection and is associated with certain malignancies, which are resistant to conventional chemotherapeutic agents poor prognosis. Latency-associated nuclear antigen 1 (LANA1) encoded by KSHV essential for segregation, replication maintenance of viral genome. In addition, LANA1 upregulates transcriptional activity signal transducer activator transcription 3 (STAT3), plays an...
Abstract Epstein–Barr virus (EBV) can infect cells in latent and lytic period cause serious disease. nuclear antigen 1 (EBNA1) is essential for the maintenance of EBV DNA episome, replication transcription. 2-phenylethynesulfonamide (PES) a small molecular inhibitor Heat shock protein 70 (Hsp70), which interact with Hsp70 disrupts its association co-chaperones substrate proteins Hsp70. In our study, we found that PES could decrease expression EBNA1, independent effects on EBNA1 transcription...
To investigate the expression of miRNA associated with hepatic fibrosis induced by Schistosoma japonicum soluble egg antigen stimulation in mouse hepatocytes (AML12), so as to lay foundation for clarifying mechanism schistosome infection leading fibrosis.The expressions miR-122, miR-182, miR-23b, miR27b and KSRP AML12 cells treated SEA were measured q-PCR. protein cell lyses was Western blotting. transfected miR-27b precursor or anti-miR-27b 24 h, then q-PCR adopted determine mRNA, detected...