A5083189279- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Pediatric health and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
Howard Hughes Medical Institute
2025
Memorial Sloan Kettering Cancer Center
2023-2025
Kettering University
2023
Washington University in St. Louis
2021
German Center for Lung Research
2020
Helmholtz Zentrum München
2020
The meninges are a membranous structure enveloping the central nervous system (CNS) that host rich repertoire of immune cells mediating CNS surveillance. Here, we report mouse contain pool monocytes and neutrophils supplied not from blood but by adjacent skull vertebral bone marrow. Under pathological conditions, including spinal cord injury neuroinflammation, CNS-infiltrating myeloid can originate brain borders display transcriptional signatures distinct their blood-derived counterparts....
Abstract Regulatory T (T reg ) cells are a specialized CD4 + cell lineage with essential anti-inflammatory functions. Analysis of adaptations to non-lymphoid tissues that enable their immunosuppressive and tissue-supportive functions raises questions about the underlying mechanisms these whether they represent stable differentiation or reversible activation states. Here, we characterize distinct colonic effector transcriptional programs. Attenuated receptor (TCR) signaling acquisition...
<title>Abstract</title> Regulatory T (Treg) cells, expressing the transcription factor Foxp3, are obligatory gatekeepers of immune responsiveness. While Foxp3 essential role in Treg l differentiation is well established, mechanisms by which governs Treg-specific transcriptional network remain incompletely understood. Here, we employed a novel chemogenetic system inducible, time-controlled degradation protein vivo to dissect its stage stage-specific functions. was indispensable for...
Abstract Regulatory T (Treg) cells represent a specialized CD4 + cell lineage with essential anti-inflammatory functions. Recent studies of the adaptations Treg to non-lymphoid tissues which enable their immunosuppressive and tissue supportive functions raise questions about underlying mechanisms these whether they stable differentiation or reversible activation states. Using novel genetic tools, we characterized transcriptional programs distinct colonic effector types. We found that...
Abstract NK cells are innate lymphocytes that respond to a variety of cytokines during viral infection. Several homeostatic and inflammatory bind receptors signal via STAT3. STAT3 can form homodimers or heterodimers. To understand the role heterodimers, we made use knockout models in which lack specific cytokine receptors. We found deficient expand less than wildtype mouse cytomegalovirus (MCMV) IL-21R IL-10R only expressed on through homodimers. However, IL-10R-deficient showed no little...