A5084524074- HIV Research and Treatment
- Multiple Sclerosis Research Studies
- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- Neuroinflammation and Neurodegeneration Mechanisms
- Mosquito-borne diseases and control
- Retinoids in leukemia and cellular processes
- Polyomavirus and related diseases
- Peripheral Neuropathies and Disorders
- Tryptophan and brain disorders
- HIV, Drug Use, Sexual Risk
- Autism Spectrum Disorder Research
- Immune Response and Inflammation
- Systemic Lupus Erythematosus Research
- Immunotherapy and Immune Responses
- Herpesvirus Infections and Treatments
- RNA Interference and Gene Delivery
- Plant Virus Research Studies
- Infectious Encephalopathies and Encephalitis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Sirtuins and Resveratrol in Medicine
- Alzheimer's disease research and treatments
- Neurological and metabolic disorders
- Cytomegalovirus and herpesvirus research
- Extracellular vesicles in disease
Morehouse School of Medicine
2003-2024
Hudson Institute
2024
John Wiley & Sons (United States)
2024
University of Maryland, Baltimore
2012-2021
Atlanta VA Medical Center
2021
Atlanta Medical Center
2021
Prevention Institute
2020
VA Maryland Health Care System
2009-2017
University of Mary
2017
Rehabilitation Research and Development Service
2017
The Neurosarcoidosis Consortium Consensus Group, an expert panel of physicians experienced in the management patients with sarcoidosis and neurosarcoidosis, engaged iterative process to define neurosarcoidosis develop a practical diagnostic approach suspected neurosarcoidosis. This aimed consensus clinical definition enhance care encourage standardization research initiatives that address this disease.The work collaboration included review manifestations establishment diagnosis disorder....
Abstract Treatment of experimental autoimmune encephalomyelitis (EAE) with resveratrol, an activator sirtuin 1 (SIRT1), reduces disease severity. This suggested that activators SIRT1, a highly conserved NAD-dependent protein deacetylase, might have immune-modulating or neuroprotective therapeutic effects in EAE. Previously, we showed SIRT1 expression increases EAE, suggesting it is adaptive response. In this study, investigated the potential function regulating EAE using SIRT1-overexpressing...
Perform an investigation of the frequency and distribution leptomeningeal enhancement on postgadolinium magnetization-prepared FLAIR (MPFLAIR) in multiple sclerosis (MS) 7 Tesla (7T) MRI to relate this finding measures brain structure lesion volumes.Twenty-nine participants with MS underwent 7T brain. Three healthy volunteers (HVs) were scanned for comparison. Areas postcontrast identified. Images segmented volumes. The relationship between clinical volumetric data was explored.Two patterns...
A consecutive series of 71 patients diagnosed with HIV-associated dementia (HAD) (1984–1994) were studied to characterize the clinical course HAD, and identify predictive markers rapid neurologic progression. Neurologic progression rate was determined from change in Memorial Sloan Kettering (MSK) severity score diagnosis death. Those most disability compared those slow or no Autopsy material immunostained for macrophage activation gp41 30 individuals. Median survival 3.3 months 6.1...
Abstract Genetic susceptibility to multiple sclerosis (MS) is associated with the MHC located on chromosome 6p21. This signal maps primarily a 1-Mb region encompassing HLA class II loci, and it segregates often HLA-DQB1*0602, -DQA1*0102, -DRB1*1501, -DRB5*0101 haplotype. However, identification of true predisposing gene or genes within haplotype has been handicapped by strong linkage disequilibrium across locus. African Americans have greater haplotypic diversity distinct patterns...
To date, the most effective treatment of HIV-1 is a combination antiretroviral therapy (cART), which reduces viral replication and reverses pathology. We investigated effect cART (RT protease inhibitors) on content extracellular vesicles (EVs) released from HIV-1-infected cells. have previously shown that EVs contain non-coding RNA, can elicit responses in recipient In this manuscript, we show TAR RNA levels demonstrate little change with addition cell lines, primary macrophages, patient...
Recent studies demonstrate that excess signaling through inflammatory pathways (e.g., toll-like receptors, TLRs) contributes to the pathogenesis of human autoimmune diseases, including lupus, diabetes, and multiple sclerosis (MS). We hypothesized codelivery a regulatory ligand TLR9, GpG oligonucleotide, along with myelin-the "self" molecule attacked in MS-might restrain pro-inflammatory typically present during myelin presentation, redirecting T cell differentiation away from populations...
The potential role of gender in the occurrence HIV-related neurocognitive impairment (NCI) and associations with markers immune activity has not been previously examined. In this study 149 antiretroviral-naïve seropositive subjects Nigeria (SP, 92 women 57 men) 58 seronegative (SN, 38 20 were administered neuropsychological testing that assessed 7 ability domains. From test scores was calculated a global deficit score (GDS), measure overall NCI. Percentages circulating monocytes plasma HIV...
Introduction Physical rehabilitation is one of the few non-pharmaceutical therapies for maintaining or improving walking ability patients with multiple sclerosis. However, travel distance to clinics, neurological disability and insurance coverage often limit access specialised services. To address these issues, we utilised a web-based system support home-based self-directed exercise programme. Methods Patients ( n = 24) were randomised either routine home sclerosis automated tele-management...
<i>Background:</i> Current evidence suggests that sun exposure and vitamin D intake, during childhood adolescence, are associated with a reduced risk of multiple sclerosis (MS). However, the role these environmental agents in timing disease symptom onset remains to be investigated. <i>Methods:</i> Using cross-sectional study design, we recruited participants from Veterans Health Administration – Multiple Sclerosis Surveillance Registry. Self-reported histories...
<i>Backgrounds/Aim:</i> Gestational and early life events have been suggested to contribute multiple sclerosis (MS) susceptibility. We assessed the effects of time place birth on age at onset MS symptoms. <i>Methods:</i> selected a national cohort 967 veterans from Multiple Sclerosis Surveillance Registry for whom month season (time) birth, birthplace (city state) were available. linear regression analyses used examine association between latitude solar radiation,...