A5026620971- RNA and protein synthesis mechanisms
- Bacterial Genetics and Biotechnology
- RNA modifications and cancer
- Viral-associated cancers and disorders
- Tuberculosis Research and Epidemiology
- Cytomegalovirus and herpesvirus research
- Cancer-related molecular mechanisms research
- Antibiotic Resistance in Bacteria
- Bacteriophages and microbial interactions
- CNS Lymphoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
University of North Carolina at Chapel Hill
2016-2020
Rutgers, The State University of New Jersey
2013-2016
Rutgers Cancer Institute of New Jersey
2016
Johnson University
2013-2016
Rutgers Sexual and Reproductive Health and Rights
2014
The Mycobacterium tuberculosis genome contains an unusually high number of toxin–antitoxin modules, some which have been suggested to play a role in the establishment and maintenance latent tuberculosis. Nine these loci belong mazEF family, encoding intracellular toxin MazF its antitoxin inhibitor MazE. Nearly every ortholog recognizes unique three- or five-base RNA sequence cleaves mRNA. As result, toxins selectively target subset transcriptome for degradation are known as “mRNA...
Toxin-antitoxin (TA) systems play key roles in bacterial persistence, biofilm formation and stress responses. The MazF toxin from the Escherichia colimazEF TA system is a sequence- single-strand-specific endoribonuclease, many studies have led to proposal that family members exclusively target mRNA. However, recent data indicate some toxins can cleave specific sites within rRNA concert with In this report, we identified repertoire of RNAs cleaved by Mycobacterium tuberculosis MazF-mt9 using...
The regulation of latency is central to herpesvirus biology. Recent transcriptome-wide surveys have uncovered evidence for promiscuous transcription across the entirety Kaposi's sarcoma-associated (KSHV) genome and postulated existence multiple viral long noncoding RNAs (lncRNAs). Next-generation sequencing studies are highly dependent on specific experimental approach particular algorithms analysis therefore benefit from independent confirmation results. antisense-to-latency transcript...
Mycobacterium tuberculosis, the causative agent of tuberculosis in humans, is a bacterium with unique ability to persist for years or decades as latent infection. This state, during which bacteria have markedly altered physiology and are thought be dormant, crucial survive stressful environments it encounters human host. Importantly, M. cells dormant state generally refractory antibiotics, most target cellular processes occurring actively replicating bacteria. The molecular switches that...
Kaposi sarcoma-associated herpesvirus (KSHV) is necessary but not sufficient for primary effusion lymphoma (PEL) development. Alterations in cellular signaling pathways are also a characteristic of PEL. Other B cell lymphomas have acquired an oncogenic mutation the myeloid differentiation response 88 (MYD88) gene. The MYD88 L265P mutant results activation interleukin-1 receptor associated kinase (IRAK). To probe IRAK/MYD88 PEL, we employed CRISPR/Cas9 technology to generate stable deletion...