Xiao Chang
A5018638729- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neurology and Historical Studies
- Genetics and Neurodevelopmental Disorders
- EEG and Brain-Computer Interfaces
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Neural dynamics and brain function
- Lipid metabolism and disorders
- Diet, Metabolism, and Disease
- Mental Health and Psychiatry
- Microbial metabolism and enzyme function
- Alcohol Consumption and Health Effects
Fudan University
2016-2025
Shanghai Innovative Research Center of Traditional Chinese Medicine
2024
Shanghai Center for Brain Science and Brain-Inspired Technology
2024
Shanghai Institute for Science of Science
2024
The First Affiliated Hospital, Sun Yat-sen University
2016
Zhongshan Hospital
2016
Sun Yat-sen University
2016
Abstract Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy subjects pooled across 41 international cohorts the ENIGMA, non-ENIGMA public datasets. Using Subtype Stage Inference (SuStaIn) algorithm, identify two distinct neurostructural subgroups by mapping spatial temporal ‘trajectory’ gray matter change in...
Schizophrenia lacks a clear definition at the neuroanatomical level, capturing sites of origin and progress this disorder. Using network-theory approach called epicenter mapping on cross-sectional magnetic resonance imaging from 1124 individuals with schizophrenia, we identified most likely "source origin" structural pathology. Our results suggest that Broca's area adjacent frontoinsular cortex may be epicenters pathophysiology in schizophrenia. These can predict an individual's response to...
Summary Background The patatin‐like phospholipase 3 ( PNPLA 3) rs738409 gene polymorphism is an important genetic determinant of non‐alcoholic fatty liver disease NAFLD ). However, the associations between fat and metabolic traits in G allele carriers allelic influence on this association have not been fully studied. Aim To investigate with serum factors carotid atherosclerosis. Methods Liver was measured by quantitative ultrasound 4300 subjects Shanghai Changfeng community analysed for its...
Abstract Objective Systemic administration of β‐aminopropionitrile to inhibit lysyl oxidase (Lox) activity improves metabolism, but it exhibits a broad spectrum effects. Clarification the role Lox in adipose tissue metabolism under high‐fat diet (HFD) conditions is needed. Methods Mice with knockout (Lox AKO ) and wild‐type mice were subjected 16‐week HFD regimen. A detailed evaluation encompassing tissue, hepatic function, systemic was conducted. RNA sequencing analysis used unravel...
Maternal education was strongly correlated with adolescent brain morphology, cognitive performances, and mental health. However, the molecular basis for effects of maternal on structural neurodevelopment remains unknown. Here, we conducted gene-environment–wide interaction study using Adolescent Brain Cognitive Development cohort. Seven genomic loci significant gene-environment interactions (G×E) regional gray matter volumes were identified, enriched biological functions related to metabolic...