Xiao Chang

ORCID: 0000-0002-8076-8110
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About
Contact & Profiles
Research Areas
  • Schizophrenia research and treatment
  • Functional Brain Connectivity Studies
  • Advanced Neuroimaging Techniques and Applications
  • Neurology and Historical Studies
  • Genetics and Neurodevelopmental Disorders
  • EEG and Brain-Computer Interfaces
  • Liver Disease Diagnosis and Treatment
  • Epigenetics and DNA Methylation
  • Adipose Tissue and Metabolism
  • Birth, Development, and Health
  • Neural dynamics and brain function
  • Lipid metabolism and disorders
  • Diet, Metabolism, and Disease
  • Mental Health and Psychiatry
  • Microbial metabolism and enzyme function
  • Alcohol Consumption and Health Effects

Fudan University
2016-2025

Shanghai Innovative Research Center of Traditional Chinese Medicine
2024

Shanghai Center for Brain Science and Brain-Inspired Technology
2024

Shanghai Institute for Science of Science
2024

The First Affiliated Hospital, Sun Yat-sen University
2016

Zhongshan Hospital
2016

Sun Yat-sen University
2016

Yuchao Jiang Cheng Luo Jijun Wang Lena Palaniyappan Xiao Chang and 95 more Shitong Xiang Jie Zhang Mingjun Duan Huan Huang Christian Gaser Kiyotaka Nemoto Kenichiro Miura Ryota Hashimoto Lars T. Westlye Geneviève Richard Sara Fernández‐Cabello Nadine Parker Ole A. Andreassen Tilo Kircher Igor Nenadić Frederike Stein Florian Thomas‐Odenthal Lea Teutenberg Paula Usemann Udo Dannlowski Tim Hahn Dominik Grotegerd Susanne Meinert Rebekka Lencer Yingying Tang Tianhong Zhang Chunbo Li Weihua Yue Yuyanan Zhang Xin Yu Enpeng Zhou Ching‐Po Lin Shih‐Jen Tsai Amanda Rodrigue David C. Glahn Godfrey D. Pearlson John Blangero Andriana Karuk Edith Pomarol‐Clotet Raymond Salvador Paola Fuentes‐Claramonte María Ángeles García‐León Gianfranco Spalletta Fabrizio Piras Daniela Vecchio Nerisa Banaj Jingliang Cheng Zhening Liu Jie Yang Ali Saffet Gönül Özgül Uslu Birce Begüm Burhanoğlu Aslihan Uyar-Demir Kelly Rootes-Murdy Vince D. Calhoun Kang Sim Melissa J. Green Yann Quidé Young‐Chul Chung Woo‐Sung Kim Scott R. Sponheim Caroline Demro Ian S. Ramsay Felice Iasevoli Andrea de Bartolomeis Annarita Barone Mariateresa Ciccarelli Arturo Brunetti Sirio Cocozza Giuseppe Pontillo Mario Tranfa Min Tae M Park Matthias Kirschner Foivos Georgiadis Stefan Kaiser Tamsyn E. Van Rheenen Susan L. Rossell Matthew Hughes Will Woods Sean Carruthers Philip Sumner Elysha Ringin Filip Španiel Antonín Škoch David Tomeček Philipp Homan Stephanie Homan Wolfgang Omlor Giacomo Cecere Dana D. Nguyen Adrian Preda Sophia I. Thomopoulos Neda Jahanshad Long‐Biao Cui Dezhong Yao

Abstract Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy subjects pooled across 41 international cohorts the ENIGMA, non-ENIGMA public datasets. Using Subtype Stage Inference (SuStaIn) algorithm, identify two distinct neurostructural subgroups by mapping spatial temporal ‘trajectory’ gray matter change in...

10.1038/s41467-024-50267-3 article EN cc-by Nature Communications 2024-07-17

Schizophrenia lacks a clear definition at the neuroanatomical level, capturing sites of origin and progress this disorder. Using network-theory approach called epicenter mapping on cross-sectional magnetic resonance imaging from 1124 individuals with schizophrenia, we identified most likely "source origin" structural pathology. Our results suggest that Broca's area adjacent frontoinsular cortex may be epicenters pathophysiology in schizophrenia. These can predict an individual's response to...

10.1126/sciadv.adk6063 article EN cc-by-nc Science Advances 2024-06-12

Summary Background The patatin‐like phospholipase 3 ( PNPLA 3) rs738409 gene polymorphism is an important genetic determinant of non‐alcoholic fatty liver disease NAFLD ). However, the associations between fat and metabolic traits in G allele carriers allelic influence on this association have not been fully studied. Aim To investigate with serum factors carotid atherosclerosis. Methods Liver was measured by quantitative ultrasound 4300 subjects Shanghai Changfeng community analysed for its...

10.1111/apt.13521 article EN Alimentary Pharmacology & Therapeutics 2016-01-13

Abstract Objective Systemic administration of β‐aminopropionitrile to inhibit lysyl oxidase (Lox) activity improves metabolism, but it exhibits a broad spectrum effects. Clarification the role Lox in adipose tissue metabolism under high‐fat diet (HFD) conditions is needed. Methods Mice with knockout (Lox AKO ) and wild‐type mice were subjected 16‐week HFD regimen. A detailed evaluation encompassing tissue, hepatic function, systemic was conducted. RNA sequencing analysis used unravel...

10.1002/oby.24253 article EN Obesity 2025-03-02

Maternal education was strongly correlated with adolescent brain morphology, cognitive performances, and mental health. However, the molecular basis for effects of maternal on structural neurodevelopment remains unknown. Here, we conducted gene-environment–wide interaction study using Adolescent Brain Cognitive Development cohort. Seven genomic loci significant gene-environment interactions (G×E) regional gray matter volumes were identified, enriched biological functions related to metabolic...

10.1126/sciadv.adp3751 article EN cc-by-nc Science Advances 2024-11-15
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