A5055500460- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Renal and related cancers
- Prenatal Substance Exposure Effects
- Neonatal Respiratory Health Research
- Fatty Acid Research and Health
- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Pediatric Urology and Nephrology Studies
- Adipose Tissue and Metabolism
- Electrolyte and hormonal disorders
- Homelessness and Social Issues
- Stress Responses and Cortisol
- Reproductive Physiology in Livestock
- Diet and metabolism studies
- Folate and B Vitamins Research
- Assisted Reproductive Technology and Twin Pregnancy
- Infant Nutrition and Health
- Blood Pressure and Hypertension Studies
- Sodium Intake and Health
- Reproductive System and Pregnancy
- Magnesium in Health and Disease
- Urological Disorders and Treatments
- COVID-19 Impact on Reproduction
The University of Queensland
2016-2025
Faculty (United Kingdom)
2021
Deakin University
2019
Children's Medical Research Institute
2016-2017
Monash University
2002-2014
The University of Melbourne
1998-2013
GTx (United States)
2009
Australian Regenerative Medicine Institute
2006
Florey Institute of Neuroscience and Mental Health
1996-2005
The University of Sydney
2004
The coronavirus disease 2019 (COVID-19) pandemic resulted in physical isolation measures many parts of the world. In Australia, nationwide restrictions included staying at home, unless seeking medical care, providing purchasing food, undertaking exercise, or attending work an essential service. All undergraduate university classes transitioned to online, mostly home-based learning. We, therefore, examined effect during early phase COVID-19 Australia (March/April) on diet (24-h recall) and...
There is some evidence, mainly from rodent studies, that any factor which alters the final total number of nephrons formed, during nephrogenesis, will result in hypertension adult life. Sheep, programmed to become hypertensive by exposure synthetic glucocorticoid (dexamethasone, 0.48 mg h-1, for 48 h) early development (~27 days gestation), were killed at 7 years age, and had nephron counting performed unbiased stereology. Mean arterial pressure was 83 +/- 4 mmHg dexamethasone (DEX) group (n...
Uteroplacental insufficiency in the rat restricts fetal growth, impairs mammary development, compromising postnatal growth; and increases adult BP. The roles of prenatal nutritional restraint on later BP nephron endowment offspring from mothers that underwent bilateral uterine vessel ligation (restricted) day 18 pregnancy were examined. Sham surgery (control) a group rats with reduced litter size (reduced; at birth to five, equivalent restricted group) used as controls. Offspring (control,...
Recent studies have linked fetal exposure to a suboptimal intrauterine environment with adult hypertension. The aims of the present study were see whether prenatal dexamethasone administered intravenously ewe between 26 28 days gestation (1) resulted in high blood pressure male and female offspring hypertension males was modulated by testosterone status, (2) altered gene expression for angiotensinogen angiotensin type 1 (AT1) receptors brain late adult. Basal mean arterial (MAP) at 2 years...
Recent studies have linked fetal exposure to a suboptimal intrauterine environment with adult hypertension. The aims of this study were twofold: 1) see whether cortisol treatment administered the ewe for 2 days at 27 gestation (term approximately 150 days) resulted in high blood pressure offspring; 2) effect same on gene expression brain 130 and lambs months age. Mean arterial was significantly higher female male offspring sheep treated than control group (females: 89+/-2 mmHg vs. 81+/-2;...
The aim of this study was to investigate the cardiovascular effects exogenous cortisol in fetal sheep, (a) between 100 and 120 days gestation when production is minimal (b) after 130 endogenous plasma starts rise. Chronically cannulated ovine fetuses (103–120 days, n = 9; 130–137 7), received sequentially a 24 h infusion vehicle (0.9% sodium chloride) at micrograms/h. Blood pressure heart rate changes bolus injections each angiotensin II noradrenaline (0.2, 0.5, 1.0, 2.0 micrograms) were...
The renin-angiotensin system is a far more complex enzymatic cascade than realized previously. Mounting evidence suggests sex-specific differences in the regulation of and arterial pressure. We examined hemodynamic responses, angiotensin II receptor subtypes, angiotensin-converting enzyme 2 gene expression levels after graded doses males females. Mean pressure was measured via telemetry male female rats response to 2-week infusion vehicle, low-dose (50 ng/kg per minute SC) or high-dose (400...
In rats, uteroplacental insufficiency induced by uterine vessel ligation restricts fetal growth and impairs mammary development compromising postnatal growth. male offspring, this results in a nephron deficit hypertension which can be reversed improving lactation Here, growth, blood pressure endowment female offspring from mothers underwent bilateral (Restricted) on day 18 of pregnancy were examined. Sham surgery (Control) reduced litter group (Reduced at birth to 5, equivalent Restricted...
G protein-coupled receptors (GPCRs) are critical for cardiovascular physiology. Cardiac cells express >100 nonchemosensory GPCRs, indicating that important physiological and potential therapeutic targets remain to be discovered. Moreover, there is a growing appreciation members of the large, distinct taste odorant GPCR families have specific functions in tissues beyond oronasal cavity, including brain, gastrointestinal tract respiratory system. To date, these chemosensory GPCRs not been...
Prenatal ethanol exposure is teratogenic, but the effects of on kidney development and health offspring are incompletely understood. Our objective was to investigate acute during pregnancy nephron endowment, mean arterial pressure, renal function in offspring. We administered or saline by gavage pregnant Sprague-Dawley rats embryonic days 13.5 14.5. At 1 month age, number 15% lower 10% ethanol-exposed males females, respectively, compared with controls. Mean measured conscious animals via...
Key points Maternal hypoxia is a common perturbation that may impair fetal development and programme sex specific disease outcomes in offspring. There growing interest the role of placenta mediating effects maternal on development, particularly late gestation during maximal growth. Multiple mechanisms have been proposed to play induced impairment placental development. Here we investigated glucocorticoids glucose regulation. This study shows determines adaptations hypoxia: while increased...
Abstract Background The pandemic inflicted by coronavirus disease 2019 (COVID-19) resulted in physical isolation measures many parts of the world. In Australia, nationwide restrictions included staying at home, unless seeking medical care, providing purchasing food, undertaking exercise, or attending work an essential service. All undergraduate university classes transitioned to online, mostly home-based learning. This disruption daily life may have consequences for eating and activity...
Maternal treatment with the synthetic glucocorticoid, dexamethasone has been reported to result in a nephron deficit and development of hypertension offspring rats. However, it is not known whether elevated maternal corticosterone (CORT), natural similar effects on blood pressure endowment. The present study investigated CORT (0.8 mg kg(-1) day(-1)) administration embryonic day 14 (E14) E15 pregnancy on: (1) number at postnatal 30 (PN30); (2) PN120; (3) receptors renal renin-angiotensin...
The effects of prenatal protein restriction on adult renal and cardiovascular function have been studied in considerable detail. However, little is known about the life-long restriction, a common condition developing world. Therefore, we determined rats combined pre- postnatal arterial pressure responses to increased dietary sodium. Nephron number was also determined. Male Sprague-Dawley were born mothers fed low [8% (wt/wt), LP] or normal [20% NP] isocaloric diet throughout pregnancy...
We investigated the effects of maternal glucocorticoid exposure in spiny mouse, a precocial species with relatively long gestation, few offspring, and which nephrogenesis is complete before birth. hypothesized that fetus to glucocorticoids formation glomeruli would result adult hypertensive offspring fewer nephrons. Furthermore, we this nephron deficit from changes expression genes involved branching morphogenesis. Osmotic pumps implanted pregnant mice at midgestation (day 20) delivered...
In rats, maternal protein restriction reduces nephron endowment and often leads to adult hypertension. Sex differences in these responses have been identified. The molecular genetic bases of phenomena can best be identified a mouse model, but effects on kidney development not examined mice. Therefore, we determined how combined prenatal postnatal mice affects organ weight, glomerular number dimensions, renal expression angiotensin receptor mRNA, both male female offspring. C57/BL6/129sv...