A5051650493- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Advanced Chemical Sensor Technologies
- Microbial Natural Products and Biosynthesis
- Insect and Pesticide Research
- Microbial Metabolic Engineering and Bioproduction
- Insect and Arachnid Ecology and Behavior
- Plant and animal studies
- Insect symbiosis and bacterial influences
- Isotope Analysis in Ecology
- Toxin Mechanisms and Immunotoxins
- Microbial Metabolism and Applications
- Essential Oils and Antimicrobial Activity
- Antimicrobial Peptides and Activities
- Plant biochemistry and biosynthesis
- Plant Parasitism and Resistance
- Forest ecology and management
- Mass Spectrometry Techniques and Applications
- Genomics and Phylogenetic Studies
- Coconut Research and Applications
- Insect Pest Control Strategies
- Vector-borne infectious diseases
- Plant and fungal interactions
- Species Distribution and Climate Change
- Ecology and Vegetation Dynamics Studies
Instituto de Investigaciones Científicas y Servicios de Alta Tecnología
2016-2024
Acharya Nagarjuna University
2016-2020
City of Knowledge
2016-2019
Abstract Specialist herbivores and pathogens could induce negative conspecific density dependence among their hosts thereby contribute to the diversity of plant communities. A small number hyperdiverse genera comprise a large portion tree in tropical forests. These closely related congeners are likely share natural enemies. Diverse defenses still allow partition niche space defined by enemies, but interspecific differences would have exceed intraspecific variation defenses. We ask whether...
The fungus-growing ant-microbe symbiosis is an ideal system to study chemistry-based microbial interactions due the wealth of described, and lack information on molecules involved therein. In this study, we employed a combination MALDI imaging mass spectrometry (MALDI-IMS) MS/MS molecular networking in system. IMS was used visualize distribution antimicrobials at inhibition zone between bacteria associated ant Acromyrmex echinatior fungal pathogen Escovopsis sp. for dereplication compounds...
Premise of the Study We describe a field collection, sample processing, and ultra‐high‐performance liquid chromatography–tandem mass spectrometry ( UHPLC ‐ MS / ) instrumental bioinformatics method developed for untargeted metabolomics plant tissue suitable molecular networking applications. Methods Results A total 613 leaf samples from 204 tree species was collected in analyzed using . Matching fragmentation spectra generated over 125,000 consensus representing unique structures, 26,410...
Abstract Amphibian populations worldwide have declined and in some cases become extinct due to chytridiomycosis, a pandemic disease caused by the fungus Batrachochytrium dendrobatidis ; however, species survived these fungal epidemics. Previous studies suggested that resistance of is presence cutaneous bacteria producing antifungal metabolites. As our understanding metabolites still limited, we assessed potential such compounds against human-relevant fungi as Aspergillus . In this work...
Herein, we present a protocol for the use of Global Natural Products Social (GNPS) Molecular Networking, an interactive online chemistry-focused mass spectrometry data curation and analysis infrastructure. The goal GNPS is to provide as much chemical insight untargeted tandem set possible connect this underlying biological questions user wishers address. This can be performed within one experiment or at repository scale. not only serves public with sample information (metadata), it also...
The marine bacterial genus Pseudoalteromonas is known for their ability to produce antimicrobial compounds. metabolite-producing capacity of has been associated with strain pigmentation; however, the genomic basis remains be explained. In this study, we sequenced whole genome six strains (three pigmented and three non-pigmented), purpose identifying biosynthetic gene clusters (BGCs) compounds detected via microbial interactions along through MS-based molecular networking. genomes were...
Herein, we present a protocol for the use of Global Natural Products Social (GNPS) Molecular Networking, an interactive online chemistry-focused mass spectrometry data curation and analysis infrastructure. The goal GNPS is to provide as much chemical insight untargeted tandem set possible connect this underlying biological questions user wishers address. This can be performed within one experiment or at repository scale. not only serves public with sample information (metadata), it also...
Plant interactions with other organisms are mediated by chemistry, yet chemistry varies among conspecific and within individual plants. The foliar metabolome—the suite of small-molecule metabolites found in the leaf—changes during leaf ontogeny is influenced signaling molecule jasmonic acid. Species differences secondary thought to play an important ecological role limiting host ranges herbivores pathogens, hence facilitating competitive coexistence plant species species-rich communities...
Cocos nucifera (C. nucifera) (the coconut palm tree) has been traditionally used to fight a number of human diseases, but only few studies have tested its components against parasites such as those that cause malaria. In this study, C. samples were collected from private natural reserve in Punta Patiño, Darien, Panama. The husk, leaves, pulp, and milk extracted evaluated the Chagas' disease or American trypanosomiasis (Trypanosoma cruzi), leishmaniasis (Leishmania donovani) malaria...
Microbes associated with fungus-growing ants represent a poorly explored source of natural products. In this study, we used mass spectrometry-based dereplication techniques for identifying set secondary metabolites produced during the microbial interaction between Streptomyces sp. (CB0028) and Escovopsis (CBAcro424). Both microorganisms were isolated from nest ant Acromyrmex echinatior. Through MALDI imaging MS/MS molecular networking, annotated siderophores: desferrioxamine B (1),...
Collectively, leishmaniasis and Chagas disease cause approximately 8 million cases more than 40,000 deaths annually, mostly in tropical subtropical regions. The current drugs used to treat these diseases have limitations many undesirable side effects; hence, new with better clinical profiles are needed. Fungal endophytes associated plants known produce a wide array of bioactive secondary metabolites, including antiprotozoal compounds. In this study, we analyzed endophytic fungal isolates