A5041629139- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Axon Guidance and Neuronal Signaling
- Angiogenesis and VEGF in Cancer
- Hippo pathway signaling and YAP/TAZ
- Ion Transport and Channel Regulation
- Zebrafish Biomedical Research Applications
- Renal and related cancers
- Erythrocyte Function and Pathophysiology
- 3D Printing in Biomedical Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Viral Infectious Diseases and Gene Expression in Insects
- Inflammatory Bowel Disease
- Biomedical Research and Pathophysiology
- Bipolar Disorder and Treatment
- Receptor Mechanisms and Signaling
- Colorectal Cancer Treatments and Studies
- Cell death mechanisms and regulation
- Pregnancy and preeclampsia studies
- Genetic Syndromes and Imprinting
- Phagocytosis and Immune Regulation
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Chronic Lymphocytic Leukemia Research
Icahn School of Medicine at Mount Sinai
2021-2025
Memorial Sloan Kettering Cancer Center
2016-2018
Kettering University
2016-2017
University of Rochester
2010-2016
Cornell University
2015
The anti-HER2 antibody trastuzumab is standard care for advanced esophagogastric (EG) cancer with ERBB2 (HER2) amplification or overexpression, but intrinsic and acquired resistance are common. We conducted a phase II study of afatinib, an irreversible pan-HER kinase inhibitor, in trastuzumab-resistant EG cancer. analyzed pretreatment tumor biopsies and, select cases, performed comprehensive characterization postmortem metastatic specimens following acquisition drug resistance. Afatinib...
Abstract Alterations in PIK3CA , the gene encoding p110α subunit of phosphatidylinositol 3-kinase (PI3Kα), are frequent head and neck squamous cell carcinomas. Inhibitors PI3Kα show promising activity various cancer types, but their use is curtailed by dose-limiting side effects such as hyperglycaemia. In present study, we explore efficacy, specificity safety targeted delivery BYL719, a inhibitor currently clinical development solid tumours. By encapsulating BYL719 into P-selectin-targeted...
Ca2+-activated BK channels in renal intercalated cells (ICs) mediate luminal flow-induced K+ secretion (FIKS), but how ICs sense increased flow remains uncertain. We examined whether PIEZO1, a mechanosensitive Ca2+-permeable channel expressed the basolateral membranes of ICs, is required for FIKS. In isolated cortical collecting ducts (CCDs), cation-selective inhibitor GsMTx4 dampened increases intracellular Ca2+ concentration ([Ca2+]i), whereas PIEZO1 activator Yoda1 [Ca2+]i and activity....
Mutations in ERBB2, the gene encoding epidermal growth factor receptor (EGFR) family member HER2, are common and drive of "HER2-negative" (not ERBB2 amplified) tumors but rare "HER2-positive" (ERBB2 breast cancer. We analyzed DNA-sequencing data from HER2-positive patients used cell lines a patient-derived xenograft model to test consequence HER2 mutations on efficacy anti-HER2 agents such as trastuzumab, lapatinib, neratinib, an irreversible pan-EGFR inhibitor. were present ~7% tumors, all...
Sex differences in renal tubular salt and water transporters, channels, claudins regulatory factors are evident all along the nephron. The influence of sex hormones on physiologic dimorphisms has been established studies removing, inhibiting or restoring their receptors. chromosome complement (SCC, XY vs. XX) transporter abundance activity is an open question. We employed Four Core Genotypes (FCG) mouse model (in which testis determining SRY gene deleted from Y inserted onto autosomal...
Plexin B1, the receptor for Semaphorin 4D (Sema4D), is expressed by melanocytes in skin. We recently showed that Sema4D suppresses activation of hepatocyte growth factor receptor, MET, melanocytes, and knockdown B1 results MET. MET signaling mediates proliferation, survival migration its associated with transformation to melanoma. In this report we investigated mechanism which inhibits activation. Our show exist as an oligomeric receptor-receptor complex association increased Sema4D....
Semaphorins are secreted and membrane bound proteins that regulate axon guidance through receptors Plexins neuropilins. Plexin B1, the Semaphorin 4D receptor, is a recently described tumor suppressor protein for melanoma. We showed B1 abrogates activation of oncogenic c-Met, by its ligand, hepatocyte growth factor (HGF), in have now investigated effect on integrin-dependent pp125(FAK) activation, small GTP-binding Rho, Integrin Rho play critical roles melanoma progression, regulation...
Abstract The PI3K/AKT/mTOR pathway is frequently deregulated in breast cancer. Specific inhibition of its key signaling nodes results cell death and tumor growth arrest, but also activation feedback loops that ultimately limit therapeutic activity. subcellular localization activity Forkhead box O3 (FOXO3) transcription factor heavily regulated by the PI3K pathway. Phosphorylation FOXO3 AKT inhibits transcriptional functions leading to survival growth. Although our understanding function...
<p>Supplementary Figure Legends</p>
<p>Additional results for dual probe EGFR and ERBB2 FISH from Patients 9, 30 32.</p>
<p>CONSORT diagram</p>
<p>Supplementary Figure Legends</p>
<p>Additional results for dual probe EGFR and ERBB2 FISH from Patients 9, 30 32.</p>
<p>CONSORT diagram</p>
<div>Abstract<p>The anti-HER2 antibody trastuzumab is standard care for advanced esophagogastric (EG) cancer with <i>ERBB2</i> (HER2) amplification or overexpression, but intrinsic and acquired resistance are common. We conducted a phase II study of afatinib, an irreversible pan-HER kinase inhibitor, in trastuzumab-resistant EG cancer. analyzed pretreatment tumor biopsies and, select cases, performed comprehensive characterization postmortem metastatic specimens...
<div>Abstract<p>The anti-HER2 antibody trastuzumab is standard care for advanced esophagogastric (EG) cancer with <i>ERBB2</i> (HER2) amplification or overexpression, but intrinsic and acquired resistance are common. We conducted a phase II study of afatinib, an irreversible pan-HER kinase inhibitor, in trastuzumab-resistant EG cancer. analyzed pretreatment tumor biopsies and, select cases, performed comprehensive characterization postmortem metastatic specimens...
Abstract Purpose: PI3K-pathway activation is the second most common genetic abnormality occurring in head and neck squamous cell carcinoma (HNSCC). Mutation or amplification of PIK3CA, gene coding for p110α subunit PI3K, occur 34%-56% HNSCC there evidence that targeting PI3Kα these tumors can be radiosensitizing. Small molecule kinase inhibitors are showing promising activity. However, use this limited by serious side effects such as hyperglycemia, diarrhea rush. In study we aimed to apply...
In the kidney, sex-specific differences in Na+ transporter profiles along nephron are now evident ("transporters" = co-transporters, channels, claudins and pumps, their phosphorylation (p)): females (F) exhibit variable vs males (M) proximal tubule (PT) higher distal (DT) collecting duct (CD) abundance activity vs. M. Circulating levels of gonadal hormones determine sex many physiologic traits, however, recent studies indicate that may also be due to chromosome complement (SCC; XX vs.XY)....