A5018448417- RNA regulation and disease
- NF-κB Signaling Pathways
- Cytokine Signaling Pathways and Interactions
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
University of California, Los Angeles
2024-2025
University of Michigan
2019
Michigan United
2019
A group of autoinflammatory disorders termed relopathies arise as a consequence NF-κB dysregulation. Genetic loss the subunit RelB in humans and mice leads to autoimmunity lethal multi-organ inflammatory pathology. Our recent study showed that this pathology is independent type I interferon signaling, further identified dysregulation set pro-inflammatory target genes. However, it remains unknown how these motif-containing Here, we report epigenome profiling studies revealing associated with...
Human astroviruses (HAstV) are understudied positive-strand RNA viruses that cause gastroenteritis mostly in children and the elderly. Three clades of astroviruses, classic, MLB-type VA-type have been reported humans. One limitation towards a better understanding these has lack physiologically relevant cell culture model supports growth all HAstV. Herein, we demonstrate infection HAstV strains belonging to three epithelium-only human intestinal enteroids (HIE) isolated from biopsy-derived...