A5017411773- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Prion Diseases and Protein Misfolding
- Genetic Neurodegenerative Diseases
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Photochromic and Fluorescence Chemistry
- Biotin and Related Studies
- Advanced Fluorescence Microscopy Techniques
National Taiwan University
2022
Academia Sinica
2022
Institute of Chemistry, Academia Sinica
2014-2022
Tamkang University
2013
TAR DNA-binding protein (TDP-43) was identified as the major ubiquitinated component deposited in inclusion bodies amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) 2006. Later on, numerous ALS-related mutations were found either glycine or glutamine/asparagine-rich region on TDP-43 C-terminus, which hinted importance of disease pathogenesis. However, how structural conversion influenced by biological significance these...
The amyloidogenic core in the TAR DNA-binding protein (TDP-43) C-terminal fragment has been characterized with its chemical, biochemical, and structural properties delineated. Various of sequence, including membrane impairment ability seeding effect, have also studied.
Huntington's disease (HD) belongs to protein misfolding disorders associated with polyglutamine (polyQ)-rich mutant huntingtin (mHtt) inclusions. Currently, it is indicated that the aggregation of polyQ-rich mHtt participates in neuronal toxicity and dysfunction. Here, we designed synthesized a polyglutamine-specific gold nanoparticle (AuNP) complex, which specifically targeted alleviated its toxicity. The AuNPs were prepared by decorating surface an amphiphilic peptide (JLD1) consisting...
We report the incorporation of salicylaldehyde derivatives onto hydrazine-tagged amyloidogenic peptides by forming photoisomerizable hydrazones. These hydrazones with positive photochromism are photostable under physiological conditions and enable photoswitching without addition external reductants or high-power irradiation. By applying superresolution microscopy, we were able to distinguish polymorphic nanoscopic structures hydrazone-incorporated in vitro different buffer conditions....