A5051790546- Phagocytosis and Immune Regulation
- Chronic Lymphocytic Leukemia Research
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Effects of Radiation Exposure
- Retinal Diseases and Treatments
- Advanced biosensing and bioanalysis techniques
- Complement system in diseases
- Biosensors and Analytical Detection
- Galectins and Cancer Biology
- Optical Imaging and Spectroscopy Techniques
- Liver Disease Diagnosis and Treatment
- Erythrocyte Function and Pathophysiology
- Autoimmune Bullous Skin Diseases
- Inflammasome and immune disorders
- Liver physiology and pathology
- Digital Holography and Microscopy
- Gout, Hyperuricemia, Uric Acid
- Molecular Biology Techniques and Applications
- Retinal Development and Disorders
- Ferroptosis and cancer prognosis
- Alzheimer's disease research and treatments
- Adenosine and Purinergic Signaling
- Cancer Immunotherapy and Biomarkers
Gryphon Scientific (United States)
2024-2025
University of Virginia
2020-2024
University of Rochester
2019-2022
University of Antwerp
2022
University of Rochester Medical Center
2019-2020
Abcam (United States)
2017
Abstract Immunogenic cell death significantly contributes to the success of anti-cancer therapies, but immunogenicity different modalities widely varies. Ferroptosis, a form that is characterized by iron accumulation and lipid peroxidation, has not yet been fully evaluated from this perspective. Here we present an inducible model ferroptosis, distinguishing three phases in process—‘initial’ associated with ‘intermediate’ correlated ATP release ‘terminal’ recognized HMGB1 loss plasma membrane...
Abstract Background Neuroinflammation is thought to contribute the pathogenesis of Alzheimer’s disease (AD), yet numerous studies have demonstrated a beneficial role for neuroinflammation in amyloid plaque clearance. We previously shown that sustained expression IL-1β hippocampus APP/PS1 mice decreases burden independent recruited CCR2 + myeloid cells, suggesting resident microglia as main phagocytic effectors IL-1β-induced To date, however, mechanisms clearance remain poorly understood....
Abstract Both cancer patients receiving radiotherapy and civilians in a mass casualty nuclear event may suffer from radiation induced damage to organ systems. Radiation liver disease (RILD) can cause acute long-term dysfunction that potentially leads death. The objective of this study was ascertain the validity quad-culture chip, micro-physiological system comprising primary human hepatocytes non-parenchymal cells (NPCs), including sinusoidal endothelial cells, hepatic stellate (HSCs),...
Radiation exposure in a therapeutic setting or during mass casualty event requires improved medical triaging, where the time to delivery and quantity of countermeasures are critical survival. Radiation-induced liver injury (RILI) fibrosis can lead death, but clinical symptoms manifest late disease pathogenesis there is no simple diagnostic test determine RILI. Because animal models do not completely recapitulate symptoms, we used human liver-on-a-chip model identify biomarkers The goals this...
Phagocytosis is a dynamic process central to immunity and tissue homeostasis. Current methods for quantification of phagocytosis largely rely on indirect or static measurements, such as target clearance dye uptake, thus provide limited information about engulfment rates processing. Improved kinetic measurements could useful, basic insights in many areas. We present live-cell, time-lapse high-content microscopy imaging method based the detection fluorescent 'voids' within phagocytes that...
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Abstract Detection of molecular biomarkers in biological fluids is used as an indicator normal processes, pathogenic and response to therapeutic intervention1,2. Using a combined signature multiple can better account for patient epidemiological heterogeneity, provide more accurate indication health2. This has necessitated the development technologies that be multiplex biomarker profiling directly from biofluids such plasma, serum, urine. Conventional assays consume excessive quantities...
Angle-resolved light scattering microscopy enables the size distribution of scatterers within a cell to be estimated non-invasively. Our group is working towards obtaining quantitative estimates mean scatterer in single cells by comparing angular scattered Mie theory models. Using phase imaging, we are able measure multiple at time and still obtain each cell's pattern individually. We now acquiring data from macrophages performing antibody-dependent cellular phagocytosis (ADCP) hopes...