A5052955925- Hepatitis B Virus Studies
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Plant Virus Research Studies
- Cervical Cancer and HPV Research
- interferon and immune responses
- Ovarian cancer diagnosis and treatment
- Global Health Workforce Issues
- Respiratory viral infections research
- Bladder and Urothelial Cancer Treatments
- Viral-associated cancers and disorders
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- Liver Diseases and Immunity
- Seaweed-derived Bioactive Compounds
- Virology and Viral Diseases
- Inflammatory Myopathies and Dermatomyositis
- Virus-based gene therapy research
- Marine Sponges and Natural Products
Bushehr University of Medical Sciences
2010-2023
Biotechnology Research Center
2010-2018
Ahvaz Jundishapur University of Medical Sciences
2010-2015
Antiviral drug resistance is one of the most common problems in medicine, and, therefore, finding new antiviral agents, especially from natural resources, seems to be necessary. This study was designed assay activity curcumin and its derivatives like gallium-curcumin Cu-curcumin on replication HSV-1 cell culture. The research performed as an vitro which different concentrations three substances including curcumin, Gallium-curcumin were tested HSV-1. cytotoxicity compounds also evaluated Vero...
Blood transfusion is considered a potential risk factor for transmission of life-threatening viral infections, including HIV, HCV and HBV infections. This study was performed to find out the prevalence trends these infections among blood donors in Southern Iran.The donor data recorded twelve regional centers from 2004 2014 were analyzed an anonymous way with respect results serological screening HBV, HCV, HIV Overall, 293454 screened infections.Most male, married, aged between 20-40 years,...
Some genotypes of human papillomaviruses can infect the genital tract and they are important infectious agents which their oncogenicity is regardable. Thus aim this study was to determine prevalence various (HPV) among women being subjected routine pap smear test in Bushehr city Iran. Based on collected data, 11(5.5%) samples were detected positive for HPV DNA 189(94.5%) out 200 negative DNA. Meanwhile 4(2%) by PCR as well. On other hand 5 didn't have after tested method. Among 11 7...
This study aims to determine the genotypes of hepatitis C virus (HCV) among blood donors at Ahvaz Blood Transfusion Centre. samples were taken from 2376 -$$$ 1795 (75.54%) male and 581(24.45%) female who referred Centre during 2007-2008. Detection anti-HCV antibody for all was carried out by ELISA confirmatory RIBA tests. HCV RT-PCR followed RFLP test positive samples. Out donors, only 55 (2.3%) showed be tests which 45(1.8%) test. Female negative antibody. The result genotyping 24 (53.3%)...
Background. Knowledge regarding prevalence of HEV in general population can be an indicator the public health and hygiene. Therefore, this study was conducted to evaluate among adults South-West Iran. Methods. Blood samples were taken from 510 participants, 206 (40.4%) males 304 (59.6%) females February July 2014. Detection anti-HEV IgG IgM antibodies carried out by ELISA test. Results. The overall rates 46.1% 1.4%, respectively. Anti-HEV seropositivity not statistically associated with...
Despite having a relatively low prevalence in the Iranian general population, burden of hepatitis C virus (HCV) infection is on rise, and predicted to be most important leading cause viral hepatitis-related mortality near future Iran.The recent population-based epidemiological studies have revealed predominant role injecting drug use increasing HCV infection.Undoubtedly, new management paradigm required drive down rising wave Iran.Priority should given young users as cornerstone lurking...
Background Although Iran is reported to be an endemic country for hepatitis E virus (HEV), data on the prevalence of HEV infection among pregnant women are scarce and epidemiology unknown in most parts country. Therefore, this study was conducted elucidate prevalence, risk factors genotypic pattern resident northern shores Persian Gulf. This first report territory. Methods From October 2016 May 2017, 1331 participated study. The mean age ± SD participants 27.93±5.7 years with a range 14–45...
Background Considering perinatal transmission and the high rate of chronic hepatitis B virus (HBV) infection in infants, diagnosis HBV during pregnancy timely interventions are great importance. Therefore, this study was performed to investigate prevalence genotype distribution associated risk factors among pregnant women northern shores Persian Gulf, South Iran. Methods Serum samples 1425 were tested for presence HBsAg HBcAb by ELISA (HBsAg one—Version ULTRA HBc Ab kits, DIA.PRO, Milan,...
Without appropriate culture systems for hepatitis E virus (HEV), sufficient natural viral proteins are difficult to generate use in serological tests. Therefore, it is important produce large amounts of HEV recombinant an economical way. The present study developed ELISAs using 2 truncated forms the open reading frame (ORF) protein order detect anti-HEV IgG serum samples. Two ORF2 were expressed Escherichia coli and purified by Ni(2+)-chelate-affinity chromatography (Qiagen, Germany). these...
The aim of this study was to design a high density multiepitope protein, which can be promising vaccine candidate against Hepatitis E virus (HEV). Initially, conserved and antigenic helper T-lymphocyte (HTL) epitopes in the HEV capsid protein were predicted by silico analysis. Subsequently, comprising four HTL with high-affinity binding HLA molecules designed, repeated times as construct. This construct synthesized cloned into pET-30a (+) vector. Then, it transformed expressed Escherichia...
The human cytomegalovirus (HCMV) is a common pathogen which usually remains asymptomatic in the healthy adults; however, it can cause symptomatic disease immunocompromised patients. risk of infection with HCMV increases ulcerative colitis (UC) patients as result receiving immunosuppressive agents.This study aimed to determine prevalence and glycoprotein B genotypes among superimposed on an UC flare that required hospitalization Imam Khomeini Hospital Ahvaz, Iran, during 2010- 2012.In this...
Hepatitis E virus (HEV) is a causative agent of acute hepatitis among people different age groups and has high mortality rate up to 30% pregnant women. Therefore, primary prevention HEV infection essential.The aim this study was obtain the highly purified truncated open reading frames 2 (ORF2) protein, which might be future vaccine candidate.The orf2 gene (orf2.1), encoding 112-660 amino acid capsid protein sequence, optimized, synthesized, cloned into pBluescript II SK(+) vector. After...
<b><i>Objective:</i></b> This study was conducted to determine the prevalence and genotype distribution of hepatitis C virus (HCV) infection among patients with type 2 diabetes mellitus (DM). <b><i>Subjects Methods:</i></b> We included 556 consecutive confirmed DM attending Diabetic Clinic Bushehr University Medical Sciences 733 nondiabetic subjects as controls. Serum levels fasting blood sugar (FBS), alanine transaminase (ALT), aspartate...
Achillea kellalensis, which is frequently used by Chaharmahal va Bakhtiarians residing in, Southwest of Iran, as a traditional herbal medicine for the treatment acute diarrhea, has been selected to examine its antiviral activities against bovine rotavirus and cell toxicity activity in MA-104 cells.The aim this study was evaluate vitro cytotoxic anti-rotavirus properties crude extracts A. kellalensis.The dried powdered flowers kellalensis were extracted with hot water ethanol 50% (v/v). The...
Hepatitis E Virus (HEV) is the causative agent of enterically transmitted acute hepatitis and has high mortality rate up to 30% among pregnant women. Therefore, development a novel vaccine desirable goal.The aim this study was construct tPAsp-PADRE-truncated open reading frame 2 (ORF2) truncated ORF2 DNA plasmid, which can assist future studies with preparation an effective against Virus.A synthetic codon-optimized gene cassette encoding protein designed, constructed analyzed by some...
Background. The aim of this study was to evaluate hepatitis E virus (HEV) specific cellular immune responses truncated ORF2 protein in Iranian patients recovered from HEV infection. Information about HEV-specific could be useful finding an effective way for development vaccine. Methods. A form containing amino acids 112-608 used stimulate peripheral blood mononuclear cells (PBMCs) separated HEV-recovered and control groups. Finally, the levels four cytokines, IFN-γ ELISPOT, cell...
This study was designed to evaluate the prevalence, genotypic patterns, and predominant mutations of hepatitis B virus (HBV) infection among diabetic patients.Serum samples were obtained from 733 patients with type 2 diabetes mellitus 782 non-diabetic controls. The presence HBsAg HBcAb determined by ELISA. Nested PCR, targeting S pre-core regions HBV genome, followed sequencing carried out determine genotypes in S, basal core promoter (BCP), genome.Of patients, 94 cases (12.82%) positive for...