A5006857530- Retinal Development and Disorders
- Retinal Diseases and Treatments
- interferon and immune responses
- Retinoids in leukemia and cellular processes
- Cytokine Signaling Pathways and Interactions
- bioluminescence and chemiluminescence research
- Retinopathy of Prematurity Studies
- Photoreceptor and optogenetics research
- Glaucoma and retinal disorders
- CRISPR and Genetic Engineering
- Connexins and lens biology
- RNA regulation and disease
- Photochromic and Fluorescence Chemistry
- Caveolin-1 and cellular processes
- Angiogenesis and VEGF in Cancer
- Herpesvirus Infections and Treatments
- Traffic Prediction and Management Techniques
- Circadian rhythm and melatonin
- Cellular transport and secretion
- Corneal Surgery and Treatments
- RNA Research and Splicing
- Immune Response and Inflammation
- Metabolism, Diabetes, and Cancer
- Traffic control and management
- Chemokine receptors and signaling
University of Pittsburgh
2023-2025
University of Cambridge
2022
University of Florida
2013-2022
Ophthalmology Associates (United States)
2002-2019
University of Washington
2015-2019
University of Florida Health Science Center
2018
Florida College
2016
University of Oklahoma
2004-2012
University of Oklahoma Health Sciences Center
2003-2012
Oklahoma City University
2003-2012
Injury induces retinal Müller glia of certain cold-blooded vertebrates, but not those mammals, to regenerate neurons. To identify gene regulatory networks that reprogram into progenitor cells, we profiled changes in expression and chromatin accessibility from zebrafish, chick, mice response different stimuli. We identified evolutionarily conserved species-specific controlling glial quiescence, reactivity, neurogenesis. In zebrafish the transition quiescence reactivity is essential for...
tunities for further investigation to enable development of therapies that may slow down or prevent vision loss, restore vision, in affected patients.Atrophic age-related macular degeneration (AMD) is included among the target inherited retinal diseases interest because first, understanding AMD contribute diseases, and second, genetics mechanism degenerations AMD. Recent Advances IRD ResearchThe treatments IRDs requires basic translational research leads improved nature causes these...
Age-related macular degeneration (AMD) is the leading cause of vision loss in western world. Recent evidence suggests that RPE and photoreceptors have an interconnected metabolism mitochondrial damage a trigger for both AMD. To test this hypothesis, study was designed to induce mice determine whether sufficient photoreceptor characteristic In study, we conditionally deleted gene encoding antioxidant enzyme, manganese superoxide dismutase (MnSOD encoded by Sod2 ) retinal pigment epithelium...
Unmanned aerial vehicles (UAVs) are gaining popularity in traffic monitoring due to their low cost, high flexibility, and wide view range. Traffic flow parameters such as speed, density, volume extracted from UAV-based videos critical for state estimation control have recently received much attention researchers. However, different stationary surveillance videos, the camera platforms move with UAVs, background motion makes it very challenging process data extraction. To address this problem,...
Retinal degenerative diseases are generally characterized by a permanent loss of light-sensitive retinal neurons known as photoreceptors, or their support cells, the pigmented epithelium (RPE). Metabolic dysfunction has been implicated common mechanism degeneration. In this study, we used drug metformin in gain-of-function approach to activate adenosine monophosphate-activated protein kinase (AMPK). We found that treatment protected photoreceptors and RPE from acute injury delayed inherited...
Purpose: AMD is the leading cause of irreversible blindness in older individuals Western world, and there are currently no therapies to halt disease progression. Studies suggest that commonly prescribed antidiabetic drug, metformin, associated with decreased risk several ocular diseases, but work has investigated effect metformin use on development AMD. Thus, we aim investigate whether developing Methods: In this retrospective case-control study, used medical records from patients than 55...
Abstract Members of the interleukin‐6 cytokine family, including leukemia inhibitory factor (LIF), signal through gp130. The neuroprotective role gp130 activation has been widely demonstrated in both CNS and PNS, but mechanism by which this is accomplished not well established. We investigated temporal cell‐specific signaling pathways induced LIF mature mouse retina. Intravitreal injection preserved photoreceptor function prevented cell death from light‐induced oxidative damage a...
Retinal photoreceptor cells contain the highest concentration of docosahexaenoic acid (DHA) in our bodies, and it has been long assumed that this is critical for supporting normal vision. Indeed, early studies using DHA dietary restriction documented reduced light sensitivity by DHA-deprived retinas. Recently, demonstrated a major route entry retina delivery across blood–retina barrier sodium-dependent lipid transporter, Mfsd2a. This discovery opened unique opportunity to analyze health...
Proteasomes are the central proteolytic machines that critical for breaking down most of damaged and abnormal proteins in human cells. Although universally applicable drugs not yet available, stimulation proteasomal activity is being analyzed as a proof-of-principle strategy to increase cellular resistance broad range proteotoxic stressors. These approaches have included proteasomes through overexpression individual proteasome subunits, phosphorylation, or conformational changes induced by...
The inflammatory response to acute ocular herpes simplex virus type 1 (HSV-1) infection in mice involves the innate and adaptive immune response, with an associated increase secretion of chemokines, including CXCL10 (interferon-inducible protein 10 kDa [IP-10]). Neutralizing antibodies mouse were used determine role during phase HSV-1 infection. Treatment HSV-1-infected antibody significantly reduced levels eye trigeminal ganglion mononuclear cell infiltration into corneal stroma. These...
Recently, we have shown that phosphoinositide 3-kinase (PI3K) in bovine rod outer segment (ROS) is activated vitro by tyrosine phosphorylation of the C-terminal tail insulin receptor (Rajala, R. V. S., and Anderson, E. (2001) Invest. Ophthal. Vis. Sci. 42, 3110–3117). In this study, investigated vivo mechanism PI3K activation rodent retina report novel finding light stimulates β-subunit (IRβ) ROS membranes, which leads to association enzyme activity with IRβ. Retinas from light- or...
Travel time is an important measurement used to evaluate the extent of congestion within road networks. This paper presents a new method estimate travel based on evolving fuzzy neural inference system. The input variables in system are traffic flow data (volume, occupancy, and speed) collected from loop detectors located at points both upstream downstream given link, output variable link time. A first order Takagi-Sugeno rule set complete inference. For training network (EFNN), two learning...
Ocular herpes simplex virus type 1 (HSV-1) infection elicits a strong inflammatory response that is associated with production of the β chemokines CCL3 and CCL5, which share common receptor, CCR5. To gain insight into role these molecules in ocular immune responses, corneas wild-type (WT) CCR5-deficient (CCR5−/−) mice were infected HSV-1 parameters measured. In absence CCR5, early infiltration neutrophils cornea was diminished. Associated this aberrant leukocyte recruitment, CCR5−/−...