A5083619901- CRISPR and Genetic Engineering
- MicroRNA in disease regulation
- Developmental Biology and Gene Regulation
- Bacteriophages and microbial interactions
- Vibrio bacteria research studies
- Cytomegalovirus and herpesvirus research
- Insect symbiosis and bacterial influences
- Viral Infections and Immunology Research
- Genetics, Aging, and Longevity in Model Organisms
- Viral gastroenteritis research and epidemiology
- Neurobiology and Insect Physiology Research
- Circular RNAs in diseases
- Congenital heart defects research
University of California, Berkeley
2025
University of Washington
2020-2024
Seattle University
2020
Vertebrate appendage regeneration requires precisely coordinated remodeling of the transcriptional landscape to enable growth and differentiation new tissue, a process executed over multiple days across dozens cell types. The heterogeneity tissues temporally-sensitive fate decisions involved has made it difficult articulate gene regulatory programs enabling individual To better understand how regenerative program is fulfilled by neural progenitor cells (NPCs) spinal cord, we analyzed...
2-mercaptoethanesulfonate (Coenzyme M, CoM) is an organic sulfur-containing cofactor used for hydrocarbon metabolism in archaea and bacteria. In archaea, CoM serves as alkyl group carrier enzymes belonging to the alkyl-CoM reductase family, including methyl-CoM reductase, which catalyzes methane formation methanogens. Two pathways biosynthesis of have been identified methanogenic archaea. The initial steps these are distinct but last two reactions, leading up formation, universally...
ABSTRACT CRISPR-Cas systems provide their prokaryotic hosts with sequence-specific immunity to foreign genetic elements, including bacteriophages and plasmids. While most interfere phage infection though cleavage of viral DNA, type VI CRISPR use the RNA-guided nuclease Cas13 recognize mRNA targets. Upon engaging target RNA, cleaves both host transcripts nonspecifically, leading a state cell dormancy that is incompatible propagation. However, whether how infected cells recover from not clear....
ABSTRACT Prokaryotic CRISPR-Cas immunity is subverted via anti-CRISPRs (Acrs), small proteins that inhibit Cas protein activities when expressed during the phage lytic cycle or from resident prophages plasmids. defenses are classified into 6 types and 33 subtypes, which employ a diverse suite of effectors differ in their mechanisms interference. As Acrs often work binding to cognate protein, inhibition almost always limited single CRISPR type. Furthermore, while acr genes frequently...