A5061259410- Cholesterol and Lipid Metabolism
- Alzheimer's disease research and treatments
- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Hormonal Regulation and Hypertension
- Computational Drug Discovery Methods
- Reproductive System and Pregnancy
- Cancer, Lipids, and Metabolism
- Protease and Inhibitor Mechanisms
- Biochemical effects in animals
- Neuroendocrine regulation and behavior
- Nuclear Receptors and Signaling
- Natural Antidiabetic Agents Studies
- Sphingolipid Metabolism and Signaling
- Vestibular and auditory disorders
- Cholinesterase and Neurodegenerative Diseases
- Peroxisome Proliferator-Activated Receptors
- Drug Transport and Resistance Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical Acid Research Studies
University of Turin
2018-2024
Fondazione IRCCS Istituto Neurologico Carlo Besta
2024
Among Alzheimer's disease (AD) brain hallmarks, the presence of reactive astrocytes was demonstrated to correlate with neuronal loss and cognitive deficits. Evidence indeed supports role as mediators changes in neurons, including synapses. However, complexity outcomes astrocyte reactivity are far from being completely elucidated. Another key AD pathogenesis is played by alterations cholesterol metabolism. Oxysterols (cholesterol oxidation products) crucial for homeostasis, we previously that...
It is now established that cholesterol oxidation products (oxysterols) are involved in several events underlying Alzheimer's disease (AD) pathogenesis. Of note, certain oxysterols cause neuron dysfunction and degeneration but, recently, some of them have been shown also to neuroprotective effects. The present study, which aimed understand the potential effects 24-hydroxycholesterol (24-OH) against intraneuronal accumulation hyperphosphorylated tau protein, stressed these latter A beneficial...
Considerable evidence indicates that cholesterol oxidation products, named oxysterols, play a key role in several events involved Alzheimer’s disease (AD) pathogenesis. Although the majority of oxysterols causes neuron dysfunction and degeneration, 24-hydroxycholesterol (24-OHC) has recently been thought to be neuroprotective also. The present study aimed at supporting this concept by exploring, SK-N-BE neuroblastoma cells, whether 24-OHC affected SIRT1/PGC1α/Nrf2 axis. We demonstrated...
The strongest genetic risk factor for sporadic Alzheimer's disease (AD) is the presence of ε4 allele apolipoprotein E (ApoE) gene, major involved in brain cholesterol homeostasis. Being astrocytes main producers and ApoE brain, we investigated impact genotype on astrocyte Two mouse astrocytic cell lines expressing human ApoE3 or ApoE4 isoform were employed. Gas chromatography-mass spectrometry (GC-MS) analysis pointed out that levels total cholesterol, precursors, various oxysterols are...
Down syndrome (DS) is a complex chromosomal disorder considered as genetically determined form of Alzheimer’s disease (AD). Maintenance brain cholesterol homeostasis essential for functioning and development, its dysregulation associated with AD neuroinflammation oxidative damage. Brain imbalances also likely occur in DS, concurring the precocious AD-like neurodegeneration. In this pilot study, we analyzed, Ts2Cje (Ts2) mouse model expression genes encoding key enzymes involved metabolism...
Abstract Background : Among Alzheimer’s disease (AD) brain hallmarks, the presence of reactive astrocytes was demonstrated to correlate with neuronal loss and cognitive deficits. Evidence indeed supports role as mediators changes in neurons, including synapses. However, complexity outcomes astrocyte reactivity are far from being completely elucidated. Another key AD pathogenesis is played by alterations cholesterol metabolism. Oxysterols (cholesterol oxidation products) crucial for...