A5075645165- Evolution and Genetic Dynamics
- Genetic diversity and population structure
- Pregnancy and preeclampsia studies
- Genetic Mapping and Diversity in Plants and Animals
- Gestational Diabetes Research and Management
- Chromosomal and Genetic Variations
- Birth, Development, and Health
- Plant Reproductive Biology
- Bioinformatics and Genomic Networks
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Plant and animal studies
- Genomics and Phylogenetic Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Pharmacogenetics and Drug Metabolism
- vaccines and immunoinformatics approaches
- Plant Molecular Biology Research
- Animal Behavior and Reproduction
- Bat Biology and Ecology Studies
- Genetic and phenotypic traits in livestock
- Gene Regulatory Network Analysis
- Mathematical and Theoretical Epidemiology and Ecology Models
- Metabolomics and Mass Spectrometry Studies
- Evolutionary Game Theory and Cooperation
- Machine Learning in Bioinformatics
- Genomics and Rare Diseases
North Carolina State University
2020-2025
North Central State College
2025
Indiana University Bloomington
2015-2023
Indiana University – Purdue University Indianapolis
2019
Indiana University
2018
The University of Texas at Austin
2010-2014
Chromosomal inversions allow genetic divergence of locally adapted populations by reducing recombination between chromosomes with different arrangements. Divergence (or hybridization species) is expected to leave signatures in the neutral diversity inverted region. Quantitative expectations for these patterns, however, have not been obtained. Here, we develop coalescent models sites linked an inversion polymorphism two populations. We consider scenarios local adaptation: selection on...
We use forward and coalescent models of population genetics to study chromosome fusions that reduce the recombination between two locally adapted loci. Under a continent-island model, fusion spreads reaches polymorphic equilibrium when it causes alleles be less than their selective advantage. In contrast, in two-deme model always spread; whether or becomes fixed depends on relative rates fused homozygotes heterozygotes. Neutral divergence around polymorphisms is markedly increased, showing...
Because they are considered rare, balanced polymorphisms often discounted as crucial constituents of genome-wide variation in sequence diversity. Despite its perceived rarity, however, long-term balancing selection can elevate genetic diversity and significantly affect observed divergence between species. Here, we discuss how ancestral be "sieved" by the speciation process, which sorts them unequally across descendant lineages. After speciation, is revealed genomic regions high This...
Chromosome inversions have long been thought to be involved in speciation and local adaptation. We little quantitative information, however, about the effects that inversion polymorphisms on reproductive isolation viability. Here we provide first estimates from any organism for total amount of associated with an segregating natural populations. sampled chromosomes 751 mosquitoes malaria vector Anopheles funestus along a 1421 km transect Cameroon traverses savannah, highland, rainforest...
Sex-antagonistic (SA) selection has major evolutionary consequences: it can drive genomic change, constrain adaptation, and maintain genetic variation for fitness. The recombining (or pseudoautosomal) regions of sex chromosomes are a promising setting in which to study SA because they tend accumulate polymorphisms recombination allows us deploy the tools molecular evolution locate targets quantify forces. Here we use coalescent models characterize patterns polymorphism expected within...
Significance Convergent evolution provides key evidence for the action of natural selection. The process convergence is often inferred because same trait appears in multiple species that are not closely related. However, different parts genome can reveal relationships among species, with some genes or regions uniting lineages appear unrelated tree. If changes traits occur these discordant regions, a false pattern be produced (known as “hemiplasy”). Here, we provide way to quantify...
Abstract Motivation The computational prediction of gene function is a key step in making full use newly sequenced genomes. Function generally predicted by transferring annotations from homologous genes or proteins for which experimental evidence exists. ‘ortholog conjecture’ proposes that orthologous should be preferred when such predictions, as they evolve functions more slowly than paralogous genes. Previous research has provided little support the ortholog conjecture, though incomplete...
Adverse pregnancy outcomes (APOs) affect a large proportion of pregnancies and represent an important cause morbidity mortality worldwide. Yet the pathophysiology APOs is poorly understood, limiting our ability to prevent treat these conditions. To search for genetic markers maternal risk four APOs, we performed multi-ancestry genome-wide association studies (GWAS) loss, gestational length, diabetes, preeclampsia. We clustered participants by their ancestry focused analyses on three...
Abstract Sex chromosomes are expected to evolve suppressed recombination, which leads degeneration of the Y and heteromorphism between X . Some sex remain homomorphic, however, factors that prevent in these cases not well understood. The homomorphic E uropean tree frogs ( H yla spp.) present an interesting paradox. Recombination males has never been observed crossing experiments, but molecular data suggestive occasional recombination hypothesis recombine tested statistically, nor X‐Y rate...
Species barriers, expressed as hybrid inviability and sterility, are often due to epistatic interactions between divergent loci from two lineages. Theoretical models indicate that the strength, direction, complexity of these genetic can strongly affect expression interspecific reproductive isolation rates at which new species evolve. Nonetheless, empirical analyses have not quantified frequency with involved in affecting fitness, whether predominantly interact synergistically or...
Abstract Epistasis is widely regarded as one of the most important phenomena in genetics. It proposes that combined effects mutations cannot be easily predicted from their individual effects. In present study... Recent studies have affirmed higher-order epistasis ubiquitous and can large on complex traits. Yet, we lack frameworks for understanding how epistatic interactions are influenced by central features cell physiology. this study, assess protein quality control machinery—a critical...
Little is known about the physiological responses and genetic mutations associated with reproductive isolation between species, especially for postmating prezygotic isolating barriers. Here, we examine changes in gene expression that accompany of 'unilateral incompatibility' (UI)-a barrier which fertilization prevented by gamete rejection tract [in this case pollen tubes (male gametophytes)] one direction a species cross, but successful reciprocal crossing direction. We use...
Understanding the genetic basis for changes in transcriptional regulation is an important aspect of understanding phenotypic evolution. Using interspecific introgression lines, we infer mechanisms divergence genome-wide patterns gene expression between nightshades Solanum pennellii and S. lycopersicum (domesticated tomato). We find that cis- trans-regulatory have had qualitatively similar contributions to this clade, unlike results from other systems. Additionally, data four tissues (shoot...
Molecular interactions affect the evolution of complex traits. For instance, adaptation may be constrained by pleiotropic or epistatic effects, both which can reflected in structure molecular interaction networks. To date, empirical studies investigating role phenotypic have been idiosyncratic, offering no clear patterns. Here, we investigated network topology genes putatively involved local to two abiotic stressors—drought and cold—in Arabidopsis thaliana . Our findings suggest that...
SUMMARY Ancient heteromorphic sex chromosomes are common in mammals, but not plants. Sex the plant family Cannabaceae, which includes species like hops and hemp, were identified a century ago because of their obviously XYs. However, we know very little about structure, nor role development economically, medicinally, culturally important flowers. Here assembled genomes, with phased chromosomes, for three XY male ( Humulus sp.), two Cannabis , monoecious individuals. Most non-recombining...
Cannabis sativa L. (marijuana, hemp) is a dioecious angiosperm species currently evolving sex chromosomes. Genetic mechanisms, primarily controlled by an XY chromosome system, appear to dictate expression in C. sativa. However, sexual also governed the interplay of hormone regulatory gene networks, influenced both genetic and environmental factors. Within species, some populations exhibit dioecy, monoecy, or gradient both. Dioecious individuals produce exclusively male female flowers, while...
Abstract Variation in gastrointestinal morphology is associated with dietary specialization across the animal kingdom. Gut length generally correlates trophic level, and increased gut herbivores a classic example of adaptation to cope diets having lower nutrient content higher proportion refractory material. However, genetic basis variation remains largely unstudied, partly due inaccessibility plasticity tissue, as well lack diversity within traditional model organisms relative that observed...
Many animals and plants have sex chromosomes that recombine over much of their length. Here we develop coalescent models for neutral sites on these chromosomes. The emphasis is expected coalescence times (proportional to the amount genetic polymorphism), but also derive some results linkage disequilibria between sites. We analyze standard model, a model with polymorphic Y under balancing selection, invasion neo-Y chromosome. may be useful testing hypotheses regarding how new originate...