A5063287742- Cardiac Ischemia and Reperfusion
- Hormonal Regulation and Hypertension
- Sexual Assault and Victimization Studies
- Immune cells in cancer
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Elder Abuse and Neglect
- Anesthesia and Neurotoxicity Research
- Intimate Partner and Family Violence
University of Toronto
2025
Hospital for Sick Children
2025
UC San Diego Health System
2020
University of California, San Diego
2020
University of Cincinnati Medical Center
2013-2019
California State University, Fresno
2019
University of California, San Francisco
2019
Background Recruitment of macrophage precursors to the adventitia plays a key role in pathogenesis abdominal aortic aneurysms ( AAA s), but molecular mechanisms remain undefined. The innate immune signaling molecule CD 14 was reported be upregulated adventitial macrophages murine model and monocytes cocultured with fibroblasts (AoAf) vitro , concurrent increased interleukin‐6 (IL‐6) expression. We hypothesized that crucial precursor recruitment early during formation. Methods Results −/−...
Chronic adventitial and medial infiltration of immune cells play an important role in the pathogenesis abdominal aortic aneurysms (AAAs). Nicotinic acid (niacin) was shown to inhibit atherosclerosis by activating anti-inflammatory G protein-coupled receptor GPR109A [also known as hydroxycarboxylic 2 (HCA2)] expressed on cells, blunting activation inflammatory cell infiltration. Here, we investigated niacin regulating AAA formation.