A5012027323- Reliability and Maintenance Optimization
- Software Reliability and Analysis Research
- Risk and Safety Analysis
- Cytokine Signaling Pathways and Interactions
- Neuroblastoma Research and Treatments
- Cancer-related molecular mechanisms research
- Financial Distress and Bankruptcy Prediction
- Nerve injury and regeneration
- Inflammatory Biomarkers in Disease Prognosis
- Management and Optimization Techniques
- Hair Growth and Disorders
- Corporate Finance and Governance
- Mesenchymal stem cell research
- Chemotherapy-induced cardiotoxicity and mitigation
- Image Retrieval and Classification Techniques
- Multiple and Secondary Primary Cancers
- RNA Research and Splicing
- Advanced Glycation End Products research
- Cancer Risks and Factors
- Parkinson's Disease Mechanisms and Treatments
- FinTech, Crowdfunding, Digital Finance
- Advanced Breast Cancer Therapies
- PI3K/AKT/mTOR signaling in cancer
- Lymphatic System and Diseases
- Biomarkers in Disease Mechanisms
Sichuan University
2013-2025
First Hospital of Jiaxing
2025
West China Hospital of Sichuan University
2013-2025
Yichun University
2024
University of Science and Technology Beijing
2013-2024
Nanning Normal University
2024
Gansu Provincial Hospital
2019-2023
Nanjing University of Finance and Economics
2020-2023
Anhui Medical University
2022
Breast Center
2020
By fusing the extracellular domain of natural killer (NK) cell receptor NKG2D to DAP12, we constructed a chimeric antigen (CAR) improve NK tumor responses. An RNA electroporation approach that provides transient expression CAR was adopted as risk mitigation strategy. Expression significantly augmented cytolytic activity cells against several solid lines in vitro and provided clear therapeutic benefit mice with established tumors. Three patients metastatic colorectal cancer were then treated...
Most industrial products degrade with usage. To capture degradation patterns and schedule condition-based maintenance actions, it is necessary to model the process predict system remaining useful life (RUL). In practice, operating environments loading conditions are dynamic stochastic, which introduces extra randomness in process. account for environmental impacts, this article proposes a nonlinear Wiener random time-varying covariate. We covariate an Ornstein–Uhlenbeck process, link rate by...
The aim of this study is to explore signal transducer and activator transcription 3 (STAT3) expression in breast cancer analyze the detailed mechanism that STAT3 contributes progression cancer.We retrospectively analyzed clinicopathologic characteristics overall survival (OS) 140 patients after curative surgery, detected expression, phosphorylated (pSTAT3) Ki-67 vascular endothelial growth factor (VEGF)-C -D tissues, adjacent nontumor tissues. Survival analysis relationship were adopted for...
Abstract The present study aimed to determine the correlation between controlling nutritional status (CONUT) and prognosis in resected breast cancer patients. Totally, 861 patients with surgical resection West China Hospital of Sichuan University 2007 2010 were included. relationship CONUT various clinicopathological factors as well was evaluated. results showed that optimal cutoff value for predict 5-year survival 3 had a higher area under ROC curve (AUC) disease free (DFS) overall (OS)...
Cell therapy and cell-based tissue engineering is becoming increasingly important in regenerative medicine. Stem cells that are characterized by self-renewal, high proliferation multiple differentiation potentials have attracted attention Maintaining the aforementioned characteristics of stem first key step Basic fibroblast growth factor (bFGF) a well-known efficiently maintains multilineage potential cells. Whether or not other factors, such as acidic (aFGF) epidermal (EGF) similar effects...
Hair follicle-derived neural crest stem cells can be induced to differentiate into Schwann in vivo and vitro. However, the underlying regulatory mechanism during cell differentiation remains poorly understood. This study isolated from human hair follicles them cells. Quantitative RT-PCR showed that microRNA (miR)-21 expression was gradually increased of After transfection with miR-21 agonist (agomir-21), capacity enhanced. By contrast, after antagonist (antagomir-21), attenuated. Further...
Non-O1/non-O139 (NOVC) strains inhabit aquatic environments and sporadically induce human illnesses. This study involved the virulence antimicrobial genetic characterization of 176 NOVC strains, comprising 25 from clinical samples 151 environmental sources, collected between 2021 2023. The susceptibility examined population was predominantly high, exhibiting only poor to colistin, with 89.2% resistance. examination genes revealed that majority were positive for glucose metabolism (als gene)...
Low-grade myofibroblastic sarcoma (LGMS) originating from breast is rare. Existing literature comprises clinical and pathological reports, with limited information on imaging characteristics. This study reports a case of LGMS the presents its characteristics, an emphasis those observed using contrast-enhanced magnetic resonance (MRI). A 50-year-old patient presented left mass for 1 year. One year before presentation, had palpated approximately 1.5 cm in size upper part without any obvious...
// Ya Liu 1, * , Jie Huang 2, Wen Li 1 Yujuan Chen Xuejuan and Jing Wang Department of Breast Surgery, Western China Hospital Sichuan University, Chengdu, 610041, 2 Rheumatology, Shenzhen Peking Guangzhou Medical Shenzhen, 518000, These authors contributed equally to this work Correspondence to: Wang, email: wangjinghxyy@163.com Keywords: STAT3; p-STAT3; breast cancer; prognostic; meta-analysis Received: July 31, 2017 Accepted: November 16, Published: January 04, 2018 ABSTRACT Objective: The...
Axillary lymph node metastasis is associated with increased risk of regional recurrence, distant metastasis, and poor survival in breast malignant neoplasm. Expression signal transducer activator transcription 3 (STAT3) significantly tumor formation, migration, invasion various cancers. In addition, vascular endothelial growth factor (VEGF) expression could promote angiogenesis increase the tumorigenesis. To determine correlations among STAT3 expression, VEGF, clinicopathological data on...
Abstract OBJECTIVE To investigate the correlation between serum homocysteine (Hcy) and cognitive impairment (CI) in patients with Parkinson’s disease (PD). METHODS Eighty-one PD were prospectively recruited this study from Feb 2015 to Jan 2018 Gansu Provincial Hospital. Of subjects, 41 diagnosed (PD-CI) vs. 40 others without (PDN). The clinical characteristic demographic features recorded for two groups. Hcy, folate vitamin B12 (VitB12) examined by high-performance liquid chromatography...
Abstract Background Sleep deprivation (SD) can lead to the development of various pathological disorders. The extracellular matrix (ECM) compositions and circadian rhythm genes are two pivotal variables SD. However, their relationships remain undefined during Methods A mouse SD model was established using a modified multiplatform water environment method. expression nerve growth factor (NGF) in hippocampus detected by an immunofluorescence (IF) Protein assessed western blot, mRNA analysis...
Abstract Many inflammation indicators have been reported to be related with patient outcomes in various cancers. Previous studies evaluated the combination of platelet (PLT) and lymphocyte monocyte ratio (COP-LMR) as a systemic inflammatory marker for prognostication lung cancer, yet its prognostic role among breast cancer patients remains unclear. In present study, total 409 surgical resection were retrospectively investigated. The receiver operating characteristic (ROC) curve was used...