A5084781890- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Hepatitis Viruses Studies and Epidemiology
- Animal Virus Infections Studies
- Respiratory viral infections research
- Virus-based gene therapy research
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Inflammation biomarkers and pathways
- Immune cells in cancer
- Infective Endocarditis Diagnosis and Management
- Immune Response and Inflammation
- Congenital Anomalies and Fetal Surgery
- Biosensors and Analytical Detection
- Neuroinflammation and Neurodegeneration Mechanisms
- Clostridium difficile and Clostridium perfringens research
- Zoonotic diseases and public health
- Streptococcal Infections and Treatments
- Otolaryngology and Infectious Diseases
- SARS-CoV-2 and COVID-19 Research
- Immunodeficiency and Autoimmune Disorders
- Advanced biosensing and bioanalysis techniques
- SARS-CoV-2 detection and testing
Administración Nacional de Laboratorios e Institutos de Salud
2016-2025
Hospital Piñero
2019-2022
Norovirus is a major cause of acute gastroenteritis worldwide. Over 30 different genotypes, mostly from genogroup I (GI) and II (GII), have been shown to infect humans. Despite three decades genome sequencing, our understanding the role genomic diversification across continents time incomplete. To close spatiotemporal gap information human noroviruses, we conducted large-scale genome-wide analyses that included nearly full-length sequencing 281 archival viruses circulating since 1970s in...
Noroviruses represent one of the leading causes outbreaks and sporadic acute gastroenteritis (AGE) cases across all age groups. Although GII.4 norovirus has been identified as primary cause most AGE outbreaks, transient predominance other genotypes reported globally. In this study, we describe a multi-province outbreak caused by potential new lineage GII.17[P17], which recently detected at high incidence in United States Europe. An amino acid analysis major viral capsid protein revealed...
Abstract Eight outbreaks of acute gastroenteritis occurred in Argentina 2004 were tested for the presence Calicivirus, Rotavirus and Astrovirus as possible causative agents. Caliciviruses found 39 out 100 samples, followed by six Astrovirus‐positive samples two Rotavirus‐positive samples. Thirty‐seven Calicivirus‐positive typed Norovirus while remaining Sapovirus. Sequence phylogenetic analyses 13 Norovirus‐positive revealed strains from genogroups GI, GII, GIV. Six grouped with GIV‐1...
Noroviruses are a leading cause of endemic and epidemic acute gastroenteritis in all age groups. However, Latin America, there limited updated data regarding circulating genotypes. The aim this study was to assess the prevalence genetic diversity norovirus outbreaks Argentina from 2013 2018. Stool samples 29 (AGE) were available for viral testing. Norovirus detected 18 (62.1%) (2 GI 16 GII). Both typed as GI.6[P11] whereas 10 different GII genotypes detected, which GII.4 viruses most...
Seasonal shifts in the predominant strains and periodic emergence of new are epidemiological features human rotaviruses. After sporadic detection two samples 1998, G3P[8] reemerged as rotavirus during 2008-2009 Argentina. Notably, 2011 6.3% (37/587) presented G3P[6] genotypes, which coincided with recent G2P[6] South America Europe. Analyses 11 gene segments four revealed that detected a decade apart (1998 2009) minor differences, while complete different genomic constellation albeit showing...
Abstract Tuberculin skin test (TST) and IFN-γ release assays are currently used to detect Mycobacterium tuberculosis ( Mtb ) infection but none of them differentiate active from latent (LTBI). Since improved tests diagnose required, we studied the immune response latency antigen Rv2626c in individuals exposed bacteria during different periods. Tuberculosis patients (TB), TB close contacts (CC: subjects for less than three months) healthcare workers (HW: at least two years) were recruited...
During the surveillance of rotavirus strains that were circulating in Argentinean children from 2000 to 2004, seven rotaviruses detected bearing genotype combination G9P[8]. The molecular characterization VP7 and NSP4 genes RNA migration patterns support hypothesis G9 could have been reintroduced into Argentina as a novel G9P[8] strain, rather than represent gene reassortants G9P[6] had previously this country.
Abstract Argentina incorporated rotavirus massive vaccination in 2015. No specific strategy has been designed to accurately measure the impact of this recent introduction on diarrhoeal disease burden our country. We assessed post-vaccine data (all-cause acute diarrhoea and laboratory-confirmed cases, genotype distribution), compared with pre-vaccination period children under 5 years age Argentina. Cross-sectional ecologic analysis was conducted from Argentine Surveillance Health System....
Group A Rotavirus has been widely described as one of the most important infantile diarrheal pathogens worldwide. In Argentina, it is responsible for over 200,000 acute diarrhea cases and from 30 to 50 deaths annually in children under 5 years. The aim this study analyze frequency, seasonality, age group distribution, circulating genotypes based on data notified 2012-2014 period turn assess pre-vaccine scenario, considering that rotavirus vaccine was introduced 2015. Data were taken Viral...
Alterations of myeloid cell populations have been reported in patients with tuberculosis (TB). In this work, we studied the relationship between myeloid-derived suppressor cells (MDSC) and monocytes subsets immunological responsiveness TB patients. Individuals active were classified as low responders (LR-TB) or high (HR-TB) according to their T responses against a lysate Mycobacterium (Mtb-Ag). Thus, LR-TB, individuals severe disease, display weaker immune response Mtb compare HR-TB,...
It has been estimated that in Argentina, rotavirus causes approximately 80,000 to 100,000 clinic consultations annually and is responsible for 40% of acute diarrhea related hospital admissions children under 5 years. In this study, national surveillance data from 2009-2011 was consulted asses prevalence, seasonality, age-group distribution as well the regional genotypes circulating. essential get deeper insight into epidemiology burden design strategies health interventions order prevent...
Rotavirus (RV) is the most common cause of childhood diarrhea. Argentina introduced RV vaccination in National Immunization Program January 2015. This study evaluates impact vaccine implementation on burden acute diarrheal disease (ADD) and positive cases, hospitalizations among children Argentina.A counterfactual time-series analysis was performed. Data ADD (2013-2018) diarrhea (2012-2018) cases aged < 5 years were collected from Healthcare Surveillance System (clinical laboratory data)....
Rotavirus is one of the leading causes diarrhea in children. In 2018, G8P[8], an unusual association genotypes, was detected with moderate frequency symptomatic children Argen-tina, unlike a previous sporadic identification 2016. The aim this study to analyze dissemination pattern G8P[8]-lineage IV strains Argentina. Nucleotide sequences VP7 gene Argentine G8P[8] (2016, 2018 and 2019) were studied by discrete phylodynamic analyses, together other worldwide relevant G8-lineage strains. Bayes...
Background: Noroviruses (NVs) are recognized as the leading cause of sporadic and epidemic acute gastroenteritis worldwide, in all age groups. Although there is increasing knowledge that NVs responsible for many outbreaks Argentina, studies to estimate prevalence cases scarce. Methods: A descriptive, observational cross-sectional study was conducted with children under 5 years attending outpatient department at “Ricardo Gutiérrez” Children’s Hospital (RGCH) Buenos Aires City between June...
Abstract We report multiple nontypeable genotype II noroviruses circulating in South America; nucleotides differed by >25% from those of other genotypes. These viruses have been the Americas for ≈20 years and show recombination with Clues to norovirus natural history can guide development treatment prevention plans.