A5049021481- Antiplatelet Therapy and Cardiovascular Diseases
- Inflammatory mediators and NSAID effects
- Genetic Associations and Epidemiology
- Atrial Fibrillation Management and Outcomes
- Signaling Pathways in Disease
- Cardiac Arrhythmias and Treatments
- RNA modifications and cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Acute Myocardial Infarction Research
- Estrogen and related hormone effects
- Receptor Mechanisms and Signaling
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Fibrosis and Remodeling
- Cardiac pacing and defibrillation studies
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2018
Maladaptive cardiac hypertrophy is a major risk factor for heart failure, which the leading cause of death worldwide. C-C motif chemokine receptor 9 (CCR9), subfamily G protein-coupled supergene family, has been highlighted as an immunologic regulator in development and homing immune cells immune-related diseases. Recently, CCR9 was found to be involved pathogenesis other diseases such cardiovascular diseases; however, effects that exerts remain elusive.We observed significantly increased...
As a particular severe phenotype of coronary artery disease (CAD), left main (LMCAD) is heritable. Genetic variants related to prostaglandin metabolism are associated with LMCAD. Cyclooxygenase-2 (COX-2), key synthase in pathways, displays high density atherosclerotic lesions and promotes early atherosclerosis CAD progression. We hypothesized that genetic COX-2 gene contribute LMCAD susceptibility compared more peripheral (MPCAD). In this study, we genotyped rs5275, rs5277, rs689466 1544...
This study was aimed to investigate the clinical relevance between glycoprotein Ia (GPIA) rs1126643C/T polymorphism and outcome of coronary artery disease after bypass graft (CABG) surgery explore involved potential mechanisms.
Objective As a marker of in vivo thromboxane generation, high-level urinary metabolites (TXA-M) increase the occurrence cardiovascular events high-risk patients. To investigate whether perioperative TXA-M level is associated with major adverse cardiac and cerebrovascular (MACCE) after coronary artery bypass graft (CABG) surgery, we designed nested case-control study. Design Observational, Setting Single-centre outcomes research Fuwai Hospital, Beijing, China. Participants One thousand six...
Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Left main coronary (LMCAD) a severe phenotype CAD has genetic component. Previous studies identified 3 inflammation-related single nucleotide polymorphisms (SNPs) contributing to development LMCAD. We integrated these SNPs into risk score for prediction enrolled 1544 patients with between 2007 2011. The individual associations LMCAD were assessed. then calculated each patient stratified low-risk,...
Objective This study aimed to evaluate the safety and efficacy of video-assisted thoracoscopic bipolar radiofrequency ablation in treatment isolated paroxysmal atrial fibrillation. Methods From September 2010 December 2016, Seventy-two consecutive patients with fibrillation underwent at Fuwai Hospital. There were 50 males 22 females an average age of(56.5±10.5) years duration with(6.5±4.8) years. 45 had previous catheter ablation. The followed up postoperative 3 months, 6 1 year...