A5027659756- MicroRNA in disease regulation
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA regulation and disease
- Genomics and Chromatin Dynamics
- RNA Interference and Gene Delivery
- Neurogenesis and neuroplasticity mechanisms
- PARP inhibition in cancer therapy
Scripps Research Institute
2019-2025
La Jolla Alcohol Research
2023
Philipps University of Marburg
2013-2018
Google (United States)
2014
Vitenparken
2013
Breast cancer is a heterogeneous tumor type characterized by complex spectrum of molecular aberrations, resulting in diverse array malignant features and clinical outcomes. Deciphering the mechanisms that fuel breast development act as determinants aggressiveness primary need to improve patient management. Among other alterations, aberrant expression microRNAs has been found human tumors, where they either oncogenes or suppressors virtue their ability finely modulate gene at...
MicroRNAs (miRNAs) are small non-coding RNAs with important functions in the development and plasticity of post-mitotic neurons. In addition to well-described cytoplasmic function miRNAs post-transcriptional gene regulation, recent studies suggested that could also be involved transcriptional regulatory processes nuclei proliferating cells. However, whether localize within nucleus neurons is unknown. Using a combination microarray hybridization RNA deep sequencing, we identified specific...
microRNAs (miRNAs) have emerged as critical regulators of neuronal dendrite development. Specific precursor (pre-)miRNAs are actively transported to dendrites, but whether this process is regulated by activity and involved in activity-dependent dendritogenesis unknown. Here we show that BDNF, a neurotrophin released response increased activity, promotes dendritic accumulation pre-miR-134. Dendritic accumulation, not transcription pre-miR-134, abrogated treatment neurons with the NMDA...
Summary Brain computations are dictated by the unique morphology and connectivity of neuronal subtypes, features established closely timed developmental events. MicroRNAs (miRNAs) critical for brain development, but current technologies lack spatiotemporal resolution to determine how miRNAs instruct steps leading subtype identity. Here, we developed new tools tackle this major gap. Fast reversible miRNA loss-of-function revealed that necessary cerebellar Purkinje cell (PC) differentiation,...