A5076416284- Blood Pressure and Hypertension Studies
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Disease and Adiposity
- Atrial Fibrillation Management and Outcomes
- Genomics and Phylogenetic Studies
- Fibroblast Growth Factor Research
- Adipokines, Inflammation, and Metabolic Diseases
- Nitric Oxide and Endothelin Effects
- Prostate Cancer Treatment and Research
- Ovarian cancer diagnosis and treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Sodium Intake and Health
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular Health and Disease Prevention
- Cell Adhesion Molecules Research
- Adipose Tissue and Metabolism
- Developmental Biology and Gene Regulation
- Renal function and acid-base balance
- Nutrition and Health in Aging
- Dialysis and Renal Disease Management
- Cardiovascular Function and Risk Factors
- Infectious Diseases and Mycology
- Heart Rate Variability and Autonomic Control
- Endometrial and Cervical Cancer Treatments
- Tryptophan and brain disorders
University of Florence
2013-2024
Azienda Ospedaliero-Universitaria Careggi
1997-2021
Maine Medical Center Research Institute
2011
Istituti di Ricovero e Cura a Carattere Scientifico
2011
Centro di Riferimento Oncologico della Basilicata
2011
University of Foggia
2011
Azienda Ospedaliera S.Giuseppe Moscati
2007-2008
University of Udine
2006
Universidad Autónoma de Madrid
2005
Yerevan State University
2005
Smoking cigarettes is the major risk factor for chronic obstructive pulmonary disease (COPD). COPD a condition associated with inflammation, characterized by macrophage activation, neutrophil recruitment, and cell injury. Many substances contained in cigarette smoke, including reactive oxygen species (ROS), have been proposed to be responsible inflammatory process of COPD. However, this issue remains unsettled. By gas chromatography/mass spectrometry (GC/MS) we show that acrolein...
Arbuscular mycorrhizal (AM) fungi are very widespread, forming symbiotic associations with ~80% of land plant species, including almost all crop plants. These considered great interest for their use as biofertilizer in low-input and organic agriculture. In addition to an improvement nutrition, AM have been reported enhance tolerance important abiotic biotic environmental conditions, especially a reduced availability resources. features, be exploited applied the field, require thorough...
Carbonic anhydrase IX is a member of α-carbonic anhydrases that preferentially expressed in solid tumors. It enables bicarbonate transport across the plasma membrane, neutralizing intracellular pH and conferring to cancer cells survival advantage hypoxic/acidic microenvironments. Overexpression carbonic tissues regulated by hypoxia inducible factor 1α - mediated transcription enzyme considered marker tumor poor outcome. The role prostate has not been fully clarified controversy arisen on...
Abstract CPX-351, a liposomal combination of cytarabine plus daunorubicin, has been approved for the treatment adults with newly diagnosed, therapy-related acute myeloid leukemia (AML) or AML myelodysplasia-related changes, because it improves survival and outcome patients who received hematopoietic stem cell transplant compared continuous infusion daunorubicin (referred to as “7 + 3” combination). Because gut dysbiosis occurring in during induction chemotherapy heavily affects subsequent...
DNA fingerprints of several Azospirillum strains, belonging to the five known species A. amazonense, brasilense, halopraeferens, irakense and lipoferum, were obtained by restriction analysis amplified 16S rDNA fragment length polymorphism histidine biosynthetic genes. Data showed that is an easy, fast, reproducible reliable tool for identification mainly at level, whereas could, in some cases, differentiate strains same species. Moreover, both analyses gave congruent results grouping...
We have previously demonstrated that the expression of soluble extracellular domain transmembrane ligand for Notch receptors, Jagged 1 (sJ1), in NIH 3T3 cells results formation a matrix-dependent chord-like phenotype, loss contact inhibition growth, and an pro-α1(I) collagen expression. In effort to define mechanism by which sJ1 induces this we report transfectants display biochemical cytoskeletal alterations consistent with activation Src. Indeed, cotransfection dominant-negative mutant Src...
Abstract Prostate carcinoma is among the most common causes of cancer-related death in men, representing 15% all male malignancies developed countries. Neuroendocrine differentiation (NED) has been associated with tumor progression, poor prognosis, and androgen-independent status. Currently, no successful therapy exists for advanced, castration-resistant disease. Because hypoxia linked to prostate cancer progression unfavorable outcome, we sought determine whether would impact degree...
Prostate cancer (PC) is still the second cause of cancer-related death among men. Although patients with metastatic presentation have an ominous outcome, vast majority PCs are diagnosed at early stage. Nonetheless, even clinically localized disease outcome may vary considerably. Other than androgen sensitivity, little known about which other signaling pathways deranged in aggressive, cancers. The elucidation such help to develop innovative therapies aimed specific molecular targets. We...
Abstract We report the rapid generation of DNA probes for several Azospirillum strains. This method does not require any knowledge genetics and/or molecular biology organism (genome) to be investigated. The procedure is based on random amplified polymorphic (RAPD) fingerprints using primers with an embedded restriction site. amplification product(s) peculiar one strain or common two more strains can purified, cloned, sequenced and used as in hybridization experiments detection identification...
To determine whether the short-term systemic and renal hemodynamic response to dopamine is influenced by clinical severity of congestive heart failure.Effects increasing doses were assessed in patients consecutively admitted for acutely decompensated failure.Intensive care unit.We enrolled 16 failure stratified (New York Heart Association [NYHA] class III, n = 8; NYHA IV, 8) two additional III as controls.Measurements carried out throughout five 20-min experimental periods: baseline,...
Abstract: Thrombin, a key mediator of blood coagulation, exerts large number cellular actions via activation specific G‐protein‐coupled receptor, named protease‐activated receptor 1 (PAR1). Several studies in experimental animals have demonstrated therapeutic potential small molecules with PAR1 antagonistic properties for treatment diseases such as vascular thrombosis and arterial restenosis. We studied the biological one highly potent, selective antagonist, SCH79797 ( N...
Vaccinium myrtillus berry extract (VME) and a recombined standard mixture (RSM) of its main native phenolic compounds were investigated for cell growth inhibition pro‐apoptotic activity on hormone‐dependent (LNCaP) hormone‐independent (PC3 DU‐145) prostate cancer (PCa) lines. Normal epithelial cells (PrEC) also studied in comparison. VME hindered anchorage‐dependent PCa proliferation dose‐dependent manner, that is, at 1/800 ( v/v ) dilution LNCaP PC3, 1/100 DU‐145 (corresponding to 14.15...
Several peptides, named adipokines, are produced by the adipose tissue. Among those, adiponectin (AD) is most abundant. AD promotes peripheral insulin sensitivity, inhibits liver gluconeogenesis and displays anti-atherogenic anti-inflammatory properties. Lower levels of related to a higher risk myocardial infarction worse prognosis in patients with coronary artery disease. However, despite favorable clinical profile, increases relation worsening heart failure (HF); this context,...
Increased reactive oxygen species (ROS) levels produced by hyperglycemia and angiotensin-II (AT-II) are considered among the pathogenic factors in malignant transformation of diabetic renal cells. We aimed to investigate potential role AT-II increased cancer risk seen diabetes; measuring oxidative damage DNA protective antioxidant defenses, including adiponectin (Adp) plasma capacity Ferric Reducing Ability Plasma (FRAP) method. In kidney streptozotocin (STZ)-induced (55 mg/kg) rats either...
Abstract Protease‐activated receptor (PAR)‐1 and PAR‐2 are reported to contribute the fibrotic process in a number of organs, including lung, liver, pancreas, kidney. The aim this study was localize expression biological activity PAR‐1 normal pathological cutaneous scars. First, we investigated immunohistochemical proteins series human scars (NS, n = 10), hypertrophic (HS, keloids (K, 10). Expression observed all types scar. Specifically, HS K, diffuse positivity found dermal cellular areas...