A5101841459- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Ear Surgery and Otitis Media
- Hearing Loss and Rehabilitation
- Genetics and Neurodevelopmental Disorders
- RNA regulation and disease
- Genomics and Rare Diseases
- Recycling and Waste Management Techniques
- Pineapple and bromelain studies
- Ziziphus Jujuba Studies and Applications
- Plant-Microbe Interactions and Immunity
- Plant Gene Expression Analysis
- Image and Object Detection Techniques
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cerebral Venous Sinus Thrombosis
- Immune Cell Function and Interaction
- Neuroscience and Neural Engineering
- Genomic variations and chromosomal abnormalities
- Plant Stress Responses and Tolerance
- Cellular transport and secretion
- Prenatal Screening and Diagnostics
- Congenital Anomalies and Fetal Surgery
- Phytochemical compounds biological activities
- Immunotherapy and Immune Responses
- Advancements in Battery Materials
Chinese PLA General Hospital
2021-2025
National Clinical Research Center for Digestive Diseases
2024-2025
National Clinical Research
2021-2025
Xi'an Jiaotong University
2025
North China Electric Power University
2023-2024
Xinjiang Academy of Agricultural Sciences
2022-2024
Ministry of Agriculture and Rural Affairs
2024
Institute of Quality Standards and Testing Technology for Agro Products
2024
Auditory neuropathy (AN) is a unique type of language developmental disorder, with no precise rate genetic contribution that has been deciphered in large cohort. In retrospective cohort 311 patients AN, pathogenic and likely variants 23 genes were identified 98 (31.5% patients), 14 mutated two or more patients. Among subgroups the prevalence was 54.4% 56.2% trios families, while 22.9% cases proband-only; 45.7% 25.6% infant non-infant group; 33.7% 0% bilateral unilateral AN cases. Most OTOF...
Abstract Background Non-isolated auditory neuropathy (AN), or syndromic AN, is marked by AN along with additional systemic manifestations. The diagnostic process challenging due to its varied symptoms and overlap other syndromes. This study focuses on two mitochondrial function-related genes which result in non-isolated FDXR TWNK , providing a summary enrichment analysis of associated elucidate the genotype-phenotype correlation underlying mechanisms. Methods Seven independent Chinese Han...
Objectives: The aim of this study was to investigate the causal relationships between sleep-associated traits and hearing difficulties in noise (HDinN) by Mendelian randomization (MR) analysis. Design: Single nucleotide polymorphisms associated with chronotype, insomnia, sleep duration, daytime dozing or sleeping, ease getting up morning were extracted from European population genome-wide association pooled data for bidirectional MR MR-Egger regression, inverse variance weighted technique,...
Objective:To investigate the clinical characteristics and treatment outcomes of patients with blast-induced hearing loss（BIHL）. Methods:The features, laboratory parameters, audiometric profiles, efficacy blast induced loss those idiopathic sudden loss（ISHL） were analyzed using t-tests, Wilcoxon rank-sum tests, chi-square a significance level set at P<0.05. Results:A total 59 in BIHL group 117 ISHL included this study. The mean age was（39.07±14.49） years, comprising 45 males 14 females. After...
Objective:To explore the clinical characteristics, audiological outcomes, and factors influencing efficacy of pharmacological treatment in patients with sudden hearing loss associated large vestibular aqueduct syndrome（LVAS）. Methods:A retrospective analysis was conducted on data 77 bilateral LVAS patients（117 ears） hospitalized for from January 1, 2009, to December 31, 2023. The inclusion criteria required that be diagnosed according Valvassori standard had received standardized treatment....
Objective:To analyze the incidence and impact on auditory prognosis of vertigo/dizziness in sudden sensorineural hearing loss patients with moderately severe above. Methods:Clinical data unilateral hospitalized from January 2008 to December 2022, aged 18-60 years, PTA≥50 dB HL, within 14 days onset were selected. Based clinical records patients, we determined whether they accompanied by vertigo/dizziness. The degree is referenced 2021 WHO grading criteria divided into severe, profound, total...
Hearing loss is a common sensory disorder that imposes significant economic burden on both society and families. However, there paucity of research analyzing the hearing loss, particularly in-depth regional analyses. This study employed convenience sampling method custom-designed questionnaire. Individuals with registered at rehabilitation institutions, schools for deaf, or deaf associations in Hebei Province were selected as participants. Data relevant to demographics, family income,...
Solar-driven interfacial evaporation has emerged as a sustainable and highly efficient technology for seawater desalination, attracting considerable attention its potential to address global water scarcity. However, challenges such low rates salt accumulation significantly hinder the performance operational lifespan of evaporators. Here, we present an innovative Janus-structured evaporator featuring distinct mechanisms through integration hydrophobic PVDF-HFP@PPy photothermal membrane...
The prompt and accurate prognostication of acute-on-chronic liver failure (ACLF) patients is crucial for clinical intervention reducing mortality. This study aimed to develop a novel prognostic model based on pathological changes, with specific focus portal vein which correlated hepatic pathology. A cohort 127 ACLF was enrolled the 90-day mortality, validated in prospective 105 patients. Demographic characteristics, laboratory indicators, imaging factor diameter (PVD) were screened, nomogram...
The content of metal ions in fruits is inseparable from plant intake trace elements and health effects the human body. To understand ion fruit pericarp melon (Cucumis melo L.) candidate genes responsible for controlling this process, we analyzed distinct parts performed RNA-seq. results showed that tissue was significantly higher than pericarp. Based on transcriptome expression profiling, found contained elevated levels DEGs. GO functional annotations included cell surface receptor...
Silver ion (Ag+) are recognized for their potent antibacterial properties; however, utilization in food preservation is restricted by factors such as inadequate stability, a transient impact, and the potential human absorption. Hydrogel-based agents capable of exerting effects establishing appropriate microenvironments, which facilitate efficient delivery antimicrobial molecules to contaminated regions food. In previous studies, we observed that chitosan (CS) silver nitrate (AgNO3) were able...
Abstract To locate and read the complex pointer meter dial for images with uneven illumination, blurred dial, tilted this paper firstly proposes an improved BRISK‐FREAK algorithm position. Then, combined Line Segment Detector (LSD) algorithm, automatic identification method is proposed. The of a large number SF 6 pressure are located results reveal that proposed has good adaptability under strong interference. computational speed 33% 17% higher than Scale‐Invariant Feature Transform (SIFT)...
Objective:To provide accurate genetic counseling, the genotype-phenotype correlation of patients with KCNQ4mutations was analyzed. Methods:Two hearing loss families, 1807956（a five-generation family 34 members） and 1707806（a three-generation 12 were recruited. The candidate variants detected by next generation sequencing technology. Sanger performed to verify co-segregation phenotype in recruited members. According American College Medical Genetics Genomics（ACMG） guideline, combined clinical...
Objective KCNQ4 is one of the most common disease‐causing genes involved in autosomal dominant non‐syndromic hearing loss. We previously found that patients with p.G285S exhibited a much more rapid deterioration loss than those other variants. To determine rate and assess disease for further analysis, we performed long‐term follow‐up these generated patient‐derived induced pluripotent stem cells (iPSCs), mouse model. Methods Patients from five‐generation family were followed up 2005 to 2022....
Abstract Objective The objective of this study was to explore the clinical characteristics and management sudden hearing loss (HL) during pregnancy, thus better guiding practice. Methods follow‐up data 17 patients (17 ears) with HL pregnancy were analyzed retrospectively (the observe group). Twelve nonpregnant female (12 similar selected as control group. prognosis two groups compared. All followed up after delivery, them readmitted hospital 1–2 months delivery. Results group had improvement...
Hyperlipidemia is characterized by elevated levels of blood lipids. The clinical manifestations are mainly atherosclerosis caused the deposition lipids in vascular endothelium. link between abnormal lipid metabolism and sudden hearing loss remains unclear. This article presents a case study accompanied familial hyperlipidemia. Pure tone audiometry indicated intermediate frequency one ear. Laboratory tests showed metabolism, genetic examination identified heterozygous mutation
As the contribution of de novo mutations (DNMs) to human genetic diseases has been gradually uncovered, analyzing global research landscape over past 20 years is essential. Because large and rapidly increasing number publications in this field, understanding current DNMs genome remains a challenge. Bibliometric analysis provides an approach for visualizing these studies using information published records specific field. This study aimed illustrate status explore trends field underlying...