A5018469378- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Treatment of Major Depression
- Genetic Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Advanced Neuroimaging Techniques and Applications
- Autism Spectrum Disorder Research
- Spinal Fractures and Fixation Techniques
Hebrew University of Jerusalem
2021-2025
Nitrous oxide is a common gaseous anesthetic used in wide range of medical procedures due to its desirable combination and analgesic properties. Deep brain stimulation surgery, well-established treatment for movement disorders like Parkinson's disease, often requires precise microelectrode recordings the awake brain's electrical signals optimal results. However, influence anesthetics on these remains critical consideration. This study investigated how nitrous general anesthesia supplemented...
The MPTP-animal model of Parkinson’s disease has significantly advanced our understanding and the dopaminergic system, helping to establish mechanisms develop therapeutic targets. non-human primate (NHP) MPTP is particularly valuable for replicating core motor symptoms, anatomical changes electrophysiological variations seen in humans. However, MPTP-injection protocols often cause substantial suffering, leading euthanasia. While some post-MPTP primates recovered spontaneously, purposefully...
It is unknown whether Parkinson's disease (PD) genetic heterogeneity, leading to phenotypic and pathological variability, also associated with variability in the unique PD electrophysiological signature. Such might have practical implications for adaptive deep brain stimulation (DBS).The aim of our work was study activity subthalamic nucleus (STN) patients pathogenic variants different disease-causing genes.Electrophysiological data from participants negative tests were compared those GBA,...
Deep brain stimulation (DBS) is commonly and safely performed for selective Parkinson's disease patients. Many centers perform DBS lead positioning exclusively under local anesthesia, to optimize microelectrode recordings (MER) testing of stimulation-related therapeutic side effects. These measures enable physiological identification the borders subdomains based on electrophysiological properties like firing rates patterns, intra-operative evaluation window, improvement placement accuracy....
Abstract Background The gold standard anesthesia for deep brain stimulation (DBS) surgery is the “awake” approach, using local alone. Although it offers high‐quality microelectrode recordings and therapeutic‐window assessment, potentially causes patients extreme stress might result in suboptimal surgical outcomes. General or sedation an alternative, but may reduce physiological testing reliability lead localization accuracy. Objectives aim to investigate a novel regimen of ketamine‐induced...
Abstract Background The gold standard anesthesia for deep brain stimulation (DBS) surgery is the “awake” approach, using local alone. While it offers high-quality microelectrode recordings and clinical assessment of therapeutic window, potentially causes patients extreme stress might result in suboptimal surgical outcomes. However, alternative general or sedation dramatically reduces reliability physiological navigation window assessment, thus diminishing accuracy lead localization. We...
Background Compensatory mechanisms in Parkinson's disease (PD) are thought to explain the temporal delay between beginning of neurodegenerative process and appearance clinical signs. The enhanced structural integrity corticospinal tract was previously suggested as one these mechanisms. Objective To understand relations anatomical, clinical, electrophysiological, genetic PD characteristics. Methods We analyzed diffusion tensor imaging (DTI) fractional anisotropy (FA) data from 40 genotyped...
Abstract Deep brain stimulation (DBS) is commonly and safely performed for selective Parkinson’s disease patients. Many centers perform DBS lead positioning exclusively under local anesthesia, to allow microelectrode recordings (MER) testing of stimulation-related therapeutic side effects. These measures enable physiological identification the targets based on electrophysiological properties like firing rates patterns, optimization placement accuracy, intra-operative evaluation window....