A5089517337- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Atomic and Subatomic Physics Research
- Photoacoustic and Ultrasonic Imaging
- Multilevel Inverters and Converters
- Advanced Radiotherapy Techniques
- Advanced MRI Techniques and Applications
- Advanced DC-DC Converters
- Ultrasound and Hyperthermia Applications
- Characterization and Applications of Magnetic Nanoparticles
- Radiomics and Machine Learning in Medical Imaging
- Ultrasound and Cavitation Phenomena
- Particle Detector Development and Performance
- Radiation Effects in Electronics
- Minerals Flotation and Separation Techniques
- Embedded Systems and FPGA Design
- Barrier Structure and Function Studies
- CCD and CMOS Imaging Sensors
- Cardiac Imaging and Diagnostics
- GaN-based semiconductor devices and materials
- Semiconductor Lasers and Optical Devices
- Magnetic Field Sensors Techniques
- Silicon Carbide Semiconductor Technologies
- Geomagnetism and Paleomagnetism Studies
- Photovoltaic System Optimization Techniques
RWTH Aachen University
2004-2025
Philips (Finland)
2006-2015
Large-volume applications of high-brightness LEDs are well established for signaling and signage. They expected to replace conventional lamps in automotive the near future incandescent, halogen fluorescent at least some general illumination within a few years. Innovative driver circuits optimized with respect functionality, efficiency, cost, size reliability an enabler successful introduction new LED based lighting products. This paper consists two parts. In first part, influence current...
Novel electronic readout schemes of analog silicon photomultipliers (SiPMs) have shown impressive timing performance <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\gamma $ </tex-math></inline-formula> -detectors in positron emission tomography (PET). However, transferring these novel concepts to the system level is a key exploit improved coincidence time resolution (CTR) (pre-)clinical imaging. In this...
Abstract Despite its high potential, non‐viral gene therapy of cancer remains challenging due to inefficient nucleic acid delivery. Ultrasound (US) with microbubbles (MB) can open biological barriers and thus improve DNA mRNA passage. Polymeric MB are an interesting alternative clinically used lipid‐coated because their stability, narrow size distribution, easy functionalization. However, besides choosing the ideal MB, it unclear whether nanocarrier‐encapsulated should be administered...
Abstract Drug delivery to central nervous pathologies is compromised by the blood-brain barrier (BBB). A clinically explored strategy promote drug across BBB sonopermeation, which relies on combined use of ultrasound (US) and microbubbles (MB) induce temporally spatially controlled opening BBB. We developed an advanced in vitro model study impact sonopermeation prototypic polymeric carrier pHPMA as a larger molecule small antiviral ribavirin. This was done under standard inflammatory...
The process of locally increasing the permeability cell membranes or layers is referred to as sonoporation sonopermeation, respectively, and opens up perspectives for drug delivery in cancer treatment by facilitating enhanced local accumulation. These effects are mediated ultrasound-activated microbubbles close proximity cells. Here, selection ultrasound settings according intended effect on biological tissue remains a challenge, especially broadly size-distributed microbubbles, which show...
In state-of-the-art positron emission (PET) tomography systems, application-specific integrated circuits (ASICs)are commonly used to precisely digitize the signals of analog silicon photo-multipliers (SiPMs). However, when operating PET electronics in a magnetic resonance (MR) system, one faces challenge mutual interference these imaging techniques. To prevent signal deterioration along long lines, with low power consumption digitizing close SiPMs are preferred. this study, we evaluate...
Resolving the depth of interaction (DOI) a γ-photon in scintillator is necessary to correct for parallax errors organ-dedicated and large-scale time-of-flight positron emission tomography (TOF-PET) scanners or enable precise recovery Compton-scattered γ-photons. Doubling number readout channels moving towards more complex detector designs are methods encode DOI, often associated with high costs. We propose DOI-capable TOFPET unit concept confining light-sharing two channels, where benefit...
This paper compares different topologies of three-level voltage-source inverters for industrial and household AC-consumers with approximately 2 kW nominal power. Due to the specific requirements on this application, inverter has operate from a symmetrical DC-link supplies single-ended load by half-bridge topology instead conventional full bridge configuration. To increase quality output voltage minimize size filter, multi-level are best suited application. focuses losses semiconductors...
Ziel/Aim Commercially available hybrid PET/MRI systems designed as whole-body compromise on sensitivity and spatial resolution. The Hyperion III platform provides flexible, MRI-compatible PET electronics to build for specific applications. is organized a tree topology. sensor tile houses photosensors read out attached scintillators. It uses Philips digital SiPMs providing 144 channels 48 × mm2. tiles are connected via flexible cables larger board, which collects the data transmits them...
The restricted bore diameter of current simultaneous positron emission tomography/magnetic resonance imaging (PET/MRI) systems can be an impediment to achieving similar patient positioning during PET/MRI planning and radiotherapy. Our goal was evaluate the B1 transmit (B1+) uniformity, B1+ efficiency, specific absorption rate (SAR) a novel radiofrequency (RF) body coil design, in which RF shielded PET detectors were integrated with aim enabling wide-bore system.We designed constructed...
Ziel/Aim Recently, long axial field-of-view (LAFOV) PET systems have been introduced, increasing the sensitivity of by at least one order magnitude. To date, these are exclusively combined with CT. The HD-MetaPET project aims to build first LAFOV PET/MRI enabling superior soft-tissue contrast and advantages simultaneous imaging such as motion correction. In addition, develops methods locally boost spatial resolution image range 1 mm detect smallest lesions or changes in tissue.
Single-sided Magnetic Particle Imaging (MPI) devices enable easy imaging of areas outside the MPI device, allowing objects any size to be imaged and improving clinical applicability. However, current single-sided face challenges in generating high-gradient selection fields experience a decrease gradient strength with increasing detection depth, which limits depth resolution. We introduce novel spatial encoding method. This method combines high-frequency alternating excitation variable offset...
Ziel/Aim Images from positron emission tomography (PET) systems require an excellent signal-to-noise ratio (SNR) allowing nuclear medicine physicians to precisely identify malignant tissue or pathogenic processes in cardiology neurology. The SNR strongly depends on the coincidence timing resolution (CTR) of a PET system. Hence, pushing CTR its physically possible limit is key improve diagnostic value image.
Ziel/Aim The clinical research community demands a variety of dedicated PET and PET/MRI scanners. As this is relatively small marked, leading industries are not providing any solutions. Hence, very flexible detector platform was needed to construct the envisioned devices.
The Unity 1.5T MR-linac has clinically been introduced to provide stereotactic precision for moving targets. We are now developing an integrated MRI/PET system with identical MRI performance planning of treatments. offers 70 cm bore size and includes PET detectors mounted in the gap a split gradient coil. Recently, first ring was installed. performed extensive interference tests acquired simultaneous images using brain phantom. Our vision is that combination will allow use information...
Within the H2020 EU project HYPMED, we have developed a PET insert that can be moved into 1.5 T MRI Philips Ingenia turning this simultaneous MRI-PET device for breast cancer applications. The consists of two independent rings with field view 28$$$\times$$$10 cm&sup2; and dual-channel local receive coils. Each ring 14$$$\times$$$2 detector blocks which each features three-layer LYSO crystal array 1.3 mm pitch. We will present first results our system.
The clinical research community demands a variety of dedicated PET and PET/MRI scanners, each tailored to the different needs questions. Hyperion III detector platform was thus designed as flexible scalable common from which desired devices can be constructed. In first projects, prototype systems were built: A brain insert for Siemens 7T MRI Scanner (FZ Juelich), breast with two simultaneously working rings (Hypmed consortium), An MR-Linac radiotherapy planning device (UMU Utrecht, Philips,...
First performance measurement results of a UHF-MRI compatible BrainPET insert for multimodal and multiparametric neuroscientific imaging applications have been obtained. The BrainPET-7T Insert was built human 7T MRI scanner from Siemens (MAGNETOM Terra) comprises total 8 UHF-MR PET modules [1]. inner diameter the axial FOV are 24.8 38.85 cm, respectively [2] attached PET-compatible channel transmit/receive coil allows <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...