A5016501862- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Mentoring and Academic Development
- Genomics and Chromatin Dynamics
- Perfectionism, Procrastination, Anxiety Studies
- T-cell and Retrovirus Studies
- Higher Education Practises and Engagement
- SARS-CoV-2 and COVID-19 Research
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Asthma and respiratory diseases
- Carbohydrate Chemistry and Synthesis
- Genomic variations and chromosomal abnormalities
- Monoclonal and Polyclonal Antibodies Research
- Proteoglycans and glycosaminoglycans research
Monash University
2022-2025
Imperial College London
2025
Vaccines work largely by generating long-lived plasma cells (LLPCs), but knowledge of how such are recruited is sparse. Although it clear that LLPCs preferentially originate in germinal centers (GCs) and relocate to survival niches bone marrow where they can persist for decades, the issues timing LLPC recruitment basis their retention remain uncertain. Here, using a genetic timestamping system mice, we show persistent PCs accrue at an approximately constant rate one cell per hour over period...
Abstract The proliferation and differentiation of antigen‐specific B cells, including the generation germinal centers (GC), are prerequisites for long‐lasting, antibody‐mediated immune protection. Affinity antigen determines cell recruitment, proliferation, differentiation, competitiveness in response, largely through determining access to T help. However, how cell‐derived signals contribute these outcomes is incompletely understood. Here, we report signature cytokine follicular helper...
The proliferation marker Ki67 has been attributed critical functions in maintaining mitotic chromosome morphology and heterochromatin organization during the cell cycle, indicating a potential role developmental processes requiring rigid cell-cycle control. Here, we discovered that despite normal fecundity organogenesis, germline deficiency resulted substantial defects specifically peripheral B T lymphocytes. This was not due to impaired but rather early lymphopoiesis at specific stages...
Abstract Mentorship refers to the guidance given by a mentor less experienced individual enhance their professional and personal development. For graduate research students, seeking independent mentors external institution offers rewarding opportunity obtain objective on variety of work, study life matters. This article outlines steps taken develop society‐based, international mentoring program over 70 participants. 6‐month aimed connect students with more senior academic scientists in...
Allergy is defined as an inappropriate immune response to a typically innocuous agent. Many allergic responses are IgE-mediated, wherein allergen-specific IgE antibodies bind mast cells and basophils elicit degranulation upon allergen reexposure. Common allergens include proteins derived from foods (e.g., milks, peanuts), pollens rye grass, birch), insect-and arthropod-derived products bee venom, house dust mite). Currently, disease-modifying treatments for allergies limited, key obstacle...
Abstract The proliferation and differentiation of antigen-specific B cells, including the generation germinal centers (GC), are prerequisites for long-lasting, high-affinity antibody-mediated immune protection. Affinity antigen determines cell recruitment, proliferation, competitiveness in response, largely through determining access to T help. However, how derived signals contribute these outcomes is incompletely understood. Here we report signature cytokine follicular helper IL-21, acts as...