A5070853689- Uterine Myomas and Treatments
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Biology and Fertility
- Endometriosis Research and Treatment
- Ovarian function and disorders
- Reproductive Health and Technologies
- Gynecological conditions and treatments
- Reproductive System and Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Reproductive Health and Contraception
- Prenatal Screening and Diagnostics
- Sperm and Testicular Function
- Ovarian cancer diagnosis and treatment
- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Estrogen and related hormone effects
- Sexual Differentiation and Disorders
- Cardiovascular Issues in Pregnancy
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Pediatric Pain Management Techniques
- Family Dynamics and Relationships
- Sex and Gender in Healthcare
- Global Maternal and Child Health
- Musculoskeletal pain and rehabilitation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Monash University
2016-2025
Monash Health
2016-2025
Monash IVF
2015-2025
Monash Children’s Hospital
2023
Australian Regenerative Medicine Institute
2023
Flinders University
2022
Monash Medical Centre
2004-2020
Hudson Institute of Medical Research
2015-2018
Brigham and Women's Hospital
2018
Harvard University
2018
<ns4:p>Female fertility decreases with increasing age, a reflection of declining oocyte quantity and quality. The menopausal transition occurs when the falls below threshold level. pattern follicular depletion as well factors, timing mechanisms surrounding both number quality remain incompletely understood. Further studies are needed to examine factors involved develop predictive models biomarkers assist in management age-related subfertility. This review summarises current knowledge...
Does female ageing have a negative effect on the DNA repair capacity of oocytes fertilised by spermatozoa with controlled levels damage?Compared to from younger females, older females reduced damaged introduced spermatozoa.The reproductive lifespan in women declines age predominantly due poor oocyte quality. This leads decreased outcomes for undergoing assisted technology (ART) treatments, compared young women. Ageing and quality been clearly associated aneuploidy, but range factors that...
Endometrial extracellular vesicles (EVs) are emerging as important players in reproductive biology. However, how their proteome is regulated throughout the menstrual cycle not known. Such information can provide novel insights into biological processes critical for embryo development, implantation, and successful pregnancy. Using mass spectrometry-based quantitative proteomics, we show that small EVs (sEVs) isolated from uterine lavage of fertile women (UL-sEV), compared to infertile women,...
Uterine fibroids are conventionally defined as clonally derived benign tumours from the proliferation of a single smooth muscle cell (SMC). We have previously identified fibroblast-like cells in fibroids, presence which raises question to whether all within fibroid same clonal origin. The first aim this study was develop fluorescence-activated sorting (FACS)-based method isolate different types human myometrium and tissues. Secondly, we aimed use X chromosome inactivation analysis determine...
Abstract STUDY QUESTION Is male age associated with the clinical outcomes of IVF/ICSI cycles for idiopathic infertility after adjustment female age? SUMMARY ANSWER Male ageing is negatively in couples independent age. WHAT IS KNOWN ALREADY The effect on treatments controversial and poorly explored. In contrast, fertility known to decline significantly beyond mid-30s, reduced oocyte quality plays an important role. negative sperm largely increasing susceptibility DNA damage. Although maternal...
Pelvic inflammatory disease (PID) is a major cause of morbidity and reproductive difficulty in women childbearing age.This article outlines the pathogenesis, clinical evaluation management PID with focus on long-term fertility-related sequelae.The presentation can be variable clinicians need to have low threshold for suspecting diagnosis. Despite good response antimicrobials, risk complications high. Therefore, history would warrant early review couples planning conception further discussion...
ovarian tissue cryopreservation (OTC) is an increasingly utilized fertility preservation method in young women, with this technique being largely implemented across Europe and Australia. Australia a pioneer of OTC, but the clinical perinatal outcomes are currently unknown for Australian population. These important as they contribute to global understanding which patients can benefit from option. To examine pregnancy mortality who have undergone and/or transplantation Victoria, Australia,...
Cultured myometrial (M) and fibroid (F) smooth muscle cells (SMCs) have been widely used as a model for the study of F growth. The aim this was to compare gene expression profiles using microarrays between six paired M tissues from hysterectomy specimens, well isolated same cultured up three passages. A total 2055 genes were differentially expressed by ANOVA all experimental groups. Among them, 128 found be statistically different tissues. More than 1100 significantly changed cells, with 648...
Use of combined oral contraceptives (OC) is associated with a significant risk thrombosis. The mechanisms this effect are not clearly defined. Tissue factor pathway inhibitor (TFPI) circulating anti-coagulant that inhibits the earliest steps in activation extrinsic coagulation pathway. It plays central role control but its contribution to thrombotic OC has been assessed. Plasma TFPI antigen and activity, VIIa, prothrombin fragments 1&2, von Willebrand antigen, fibrinogen, low density...