A5064539571- Spinal Cord Injury Research
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Glutathione Transferases and Polymorphisms
- Nerve injury and regeneration
- High Altitude and Hypoxia
- Congenital Diaphragmatic Hernia Studies
- Trauma Management and Diagnosis
- Sulfur Compounds in Biology
- Anesthesia and Neurotoxicity Research
- Redox biology and oxidative stress
- Proteoglycans and glycosaminoglycans research
- Sleep and Wakefulness Research
- Neuroendocrine regulation and behavior
- Names, Identity, and Discrimination Research
University of Kentucky
2019-2024
The specific roles that different types of neurons play in recovery from injury is poorly understood. Here, we show increasing the excitability ipsilaterally projecting, excitatory V2a using designer receptors exclusively activated by drugs (DREADDs) restores rhythmic bursting activity to a previously paralyzed diaphragm within hours, days, or weeks following C2 hemisection injury. Further, decreasing impairs tonic after as well activation inspiratory chemosensory stimulation, but does not...
Idiopathic pulmonary fibrosis (IPF) is a chronic, devastating lung disease characterized by progressive and dysregulated wound repair that negatively affect function. Although fibroblasts are important in mechanisms following injury, differentiation into myofibroblasts the presence of TGF-β resistance to apoptosis can promote progression fibrosis. Apoptosis signal regulating kinase 1 (ASK1) member mitogen activated protein (MAP) family known apoptosis. The objective this study was test...
Abstract High-cervical spinal cord injury often disrupts respiratory motor pathways and disables breathing in the affected population. Moreover, cervically injured individuals are at risk for developing acute lung injury, which predicts substantial mortality rates. While correlation between has been found clinical setting, field lacks an animal model to interrogate fundamental biology of this relationship. To begin address gap knowledge, we performed experimental cervical (N = 18) alongside...
Each year, 17,700 Americans suffer a spinal cord injury, over half of which occur at the cervical level. These high level injuries can interrupt bulbospinal neurons that innervate phrenic motornucleus, origin nerve. Loss these descending inputs to nerve paralyzes ipsilateral diaphragm, leading breathing impairments. One approach promote recovery function is by enhancing plasticity through strengthening synapses or activating spared but latent pathways in cord. Activation crossed pathway lead...
In spinal cord injury (SCI), initial mechanical trauma causes debilitating primary damage to neural cells and blood vessels. Following this, secondary cascades of downstream events occur, including inflammation, ischemia, excitotoxicity — an increase in intracellular Ca2+ concentration from overactive glutamate (Glu) receptors leading cell death. Additionally, there is upregulation the perineuronal net (PNN), a lattice‐like structure extracellular matrix (ECM) which modulates communication...
Spinal cord injury (SCI) most commonly occurs at the cervical level and can interrupt descending neural pathways, causing paralysis of diaphragm, as well profound breathing motor difficulties which threaten survival greatly decrease quality life. Intermittent hypoxia (IH) treatment is often utilized in preclinical models to attenuate deficits resulting from SCI by inducing a prolonged increase respiratory output known long term facilitation (LTF), form plasticity. IH typically consists...
Following an experimental C2 spinal cord hemisection in rats, there is a gradual spontaneous recovery of breathing function that can take place over time. Additionally, interventions at later time points are more effective after injury. What not known the mechanism mediating this observation. To begin to answer question, we investigated role gut microbiome Recent studies have emerged suggesting has critical implications on proper functioning central nervous system (CNS). Indeed, dysbiosis,...
Abstract High-cervical spinal cord injury (SCI) often disrupts respiratory motor pathways and disables breathing in the affected population. Moreover, cervically injured individuals are at risk for developing acute lung (ALI), which predicts substantial mortality rates. While correlation between ALI SCI has been found clinical setting, field lacks an animal model to interrogate fundamental biology of this relationship. To begin address gap, we performed experimental cervical assessed adult...