A5045001759- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Reproductive Biology and Fertility
- Acute Myeloid Leukemia Research
- Renal and related cancers
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Assisted Reproductive Technology and Twin Pregnancy
- Metabolism, Diabetes, and Cancer
- Ovarian function and disorders
- Pluripotent Stem Cells Research
- Mesenchymal stem cell research
- Gynecological conditions and treatments
- Congenital heart defects research
- Cancer, Hypoxia, and Metabolism
- Tissue Engineering and Regenerative Medicine
Vilnius University
2021-2024
When looking for the causes and treatments of infertility, much attention is paid to one reproductive tissues—the endometrium. Therefore, endometrial stem cells are an attractive target infertility studies in women unexplained origin. Menstrual blood (MenSCs) morphologically functionally similar derived directly from endometrium; with dual expression mesenchymal embryonic cell markers, they proliferate regenerate better than bone marrow cells. In addition, menstrual extracted a non-invasive...
Cryopreservation of placenta tissue for long-term storage provides the opportunity in future to isolate mesenchymal stromal cells that could be used cell therapy and regenerative medicine. Despite being widely used, established cryopreservation protocols freezing thawing still raise concerns about their impact on molecular characteristics, such as epigenetic regulation. In our study, we compared characteristics human placental (hPMSCs) isolated from fresh (native) cryopreserved (cryo)...
Metabolic landscape and sensitivity to apoptosis induction play a crucial role in acute myeloid leukemia (AML) resistance. Therefore, we investigated the effect of metformin, medication that also acts as an inhibitor oxidative phosphorylation (OXPHOS), MCL-1 S63845 AML cell lines NB4, KG1 chemoresistant KG1A cells. The impact compounds was evaluated using fluorescence-based metabolic flux analysis, assessment mitochondrial Δψ cellular ROS, trypan blue exclusion, Annexin V-PI XTT tests for...
Abstract Stem cells’ differentiation toward cardiac lineage is a complex process dependent on various alterations in molecular basis and regulation pathways. The aim of the study to show that endometrium-derived stromal cells – menstrual, endometrial endometriotic, could be an attractive source for examination mechanisms underlying cardiomyogenesis. After treatment with Decitabine, Angiotensin II TGF-β1, demonstrated morphological dedifferentiation into early cardiomyocyte-like expressed...
Infertility is one of the most rapidly increasing global health concerns 21st century. Embryo quality and endometrial thickness receptivity are main factors for successful embryo implantation pregnancy development. Nevertheless, until now, there has been a lack understanding about regulation human endometrium function its structure. This raises demand more research in these fields. In our study, we analyzed genetic epigenetic changes tissue's samples isolated from females admitted treatment...
The prevalence of infertility is getting higher over the years. increasing age first-time parents, although economically more desirable, can cause various biological problems from low natural conception rate to poor pregnancy outcomes. growing demand for assisted reproductive technology procedures worldwide draws medical specialists' and scientists' attention elements which could lead successful conception, such as follicular fluid (FF) hormones. In this study, we analyzed effects exposure...
Gestational diabetes mellitus is an increasingly diagnosed metabolic disorder during pregnancy with unknown pathological pathways. Taking into account the growing numbers of women who are conceiving after assisted reproductive technologies, they comprise engaging target group for gestational etiopathogenesis research. In terms metabolism and genetics, as evidence shows, both unexplained infertility pose challenges their interpretation due to complex bodily processes.
Acute myeloid leukemia (AML) is a heterogeneous disease. A significant proportion of AML patients refractory to clinical treatment or relapses. Our aim determine new potential prognosis markers. We investigated various cell fate and epigenetic regulation important gene level differences between responsive patient groups at diagnosis stage after using RT-qPCR. demonstrated that oncogenic MYC WT1 metabolic IDH1 expression was significantly higher cycle inhibitor CDKN1A (p21) lower in patients'...
Abstract Background. Infertility can negatively affect mental health. Conversely, it is also hypothesized that psychological imbalance may exert a damaging influence on reproductive function. Unfortunately, until now has been difficult to objectively explain these relations. Certain researchers suggest genetic and epigenetic mechanisms could be factors. The aim of this study was investigate the connection between infertility, anxiety (or) depression by examining underlying genetics, so we...