A5048767232- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood transfusion and management
- Trauma and Emergency Care Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Cardiac Arrest and Resuscitation
- Acute Kidney Injury Research
- Hemodynamic Monitoring and Therapy
- Renal function and acid-base balance
University of Helsinki
2020-2025
Helsinki University Hospital
2020-2025
<h3>Importance</h3> In cardiac surgery, albumin solution may maintain hemodynamics better than crystalloids and reduce the decrease in platelet count excessive fluid balance, but randomized trials are needed to compare effectiveness of these approaches reducing surgical complications. <h3>Objective</h3> To assess whether 4% compared with Ringer acetate as cardiopulmonary bypass prime perioperative intravenous volume replacement reduces incidence major postoperative complications patients...
To study the association between bleeding and acute kidney injury (AKI). Post-hoc of a randomized trial 4% albumin versus Ringer's acetate for cardiopulmonary bypass priming perioperative volume replacement. Single-center study. 1,386 on-pump cardiac surgical patients. AKI was defined by Kidney Disease: Improving Global Outcomes creatinine criteria, Universal Definition Perioperative Bleeding (UDPB) classification. With univariably independent factors, two logistic regression analyses (Model...
Abstract Background In cardiac surgery with cardiopulmonary bypass (CPB), large amounts of fluids are administered. CPB priming crystalloid solution causes marked hemodilution and fluid extravasation. Colloid solutions may reduce overload because they have a better volume expansion effect than crystalloids. The European Medicines Agency does not recommend the use hydroxyethyl starch (HES) due to harmful renal effects. Albumin impair blood coagulation but findings on kidney function...
To study the quantitative potency of plasma albumin on cardioprotection in terms creatinine kinase-myocardial band mass (CK-MBm) on-pump cardiac surgery.