Abstract Background High job demands, low control, and their combination (job strain) may increase workers' risk of depression. Previous research is limited by small populations, not controlling for previous depression, relying on the same informant reporting exposure outcome. This study aims to examine relationship between objectively measured workplace factors developing clinical depression among Swedish working population while psychiatric diagnoses sociodemographic factors. Methods...

The incidence of major depression among adults has been shown to be socially differentiated, and there are reasons seek explanations for this before adulthood. In cohort study, we examined whether academic performance in adolescence predicts adulthood, the extent which externalizing disorders explain association. We followed 26,766 Swedish women men born 1967–1982 from last year compulsory school, at age about 16, up 48 years age. investigated association between grade point average (GPA,...

Objective Academic performance in youth, measured by grade point average ( GPA ), predicts suicide attempt, but the mechanisms are not known. It has been suggested that general intelligence might underlie association. Methods We followed 26 315 Swedish girls and boys population‐representative cohorts, up to maximum 46 years of age, for first attempt hospital records. Associations between at age 16, IQ school 13 were investigated Cox regressions mediation analyses. Results There was a clear...

Background Cognitive ability/intelligence quotient (IQ) in youth has previously been associated with subsequent completed and attempted suicide, but little is known about the mechanisms underlying associations. This study aims to assess roles of various risk factors over life course explaining observed relationships. Method The present investigation a cohort based on data IQ test performance covariates, recorded 49 321 Swedish men conscripted 1969–1970, at ages 18–20 years. Information...

Background Cardiovascular fitness influences many aspects of brain function. However, the relationship between cardiovascular and suicidal behaviour is unknown. Therefore, we aimed to determine whether at age 18 years associated with future risk suicide attempt/death. Method We performed a population-based Swedish longitudinal cohort study male conscripts no previous or ongoing mental illness ( n = 1 136 527). The conscription examination, which took place during 1968–2005, included cycle...

Abstract Objective To determine whether parenthood among 25‐ to 44 ‐ year old s is associated with a lower suicide rate in men and women Sweden, this explained by selection into parenthood. Methods In total, 1,582,360 Swedish men, born between 1967 1985, childless at their 25 th birthday, were followed from 1992 2011. All data originated linkage national registers. Cox regression models used time‐varying status estimate adjusted hazard ratios 95% confidence intervals (aHR;CI) for suicide....

Psychosocial workplace factors may be associated with alcohol-related morbidity, but previous studies have had limited opportunities to take non-occupational explanatory into account. The aim of this study is investigate associations between job control, demands and their combination (job strain) diagnosed morbidity while accounting for several potentially confounding measured across the life-course, including education.Job strain were using Swedish exposure matrix measuring psychosocial...

Objective To investigate the association between job control, demands and their combination (job strain) suicide attempts deaths among male female workers in Sweden. Methods Job control were measured separately for men women using a exposure matrix, which was linked to around three million individuals based on occupational title 2005. Suicide hospital cause of death registers from 2006 2016. HRs estimated discrete proportional hazards models with annually updated age as time axis. Models...

An association of higher body mass index (BMI) with lower risk attempted and completed suicide has been reported. In contrast, increasing BMI found to be associated depression other factors for suicidal behavior. We aimed investigate this possible paradox in a cohort comprising 49 000 Swedish men. BMI, mental health, lifestyle socioeconomic measures were recorded at conscription 1969-70, ages 18-20. Information on 1973-2008 1971-2008 was obtained from national records. Hazard ratios (HR)...

Abstract Background Both low intelligence and emotional control have previously been linked to a higher risk of suicide, but it is unknown whether the associations apply consistently over life course. Methods The study was based on data control, collected from 48 738 Swedish men conscripted in 1969–1970, at ages 18–20 years. were national registers giving information subsequent suicidal behavior (completed attempted suicide) up age 59 investigated using logistic regression Cox proportional...

Objective To investigate the association between intelligence and disability pension due to mental, musculoskeletal, cardiovascular, substance-use disorders among men women, assess role of childhood social factors adulthood work characteristics. Methods Two random samples women born 1948 1953 (n = 10 563 9 434), tested for general at age 13, were followed in registers until 2009. Physical psychological strains assessed using job exposure matrices. Associations examined Cox proportional...

Low cognitive ability in late adolescence has previously been shown to be associated with disability pension (DP) young adulthood. However, most DP's are granted later working life, and the mechanisms of association not fully understood. We aimed investigate between DP at ages 40-59, role individual socioeconomic factors. Information on ability, health status, personality aspects behaviours age 18-20 was obtained from 1969-70 conscription cohort, comprising 49 321 Swedish men. Data 1991-2008...

To evaluate the risk of severe COVID-19 in individuals with mental disorders, substance use and common disorders total adult population Region Stockholm (N = 1,516,270), to explore possible underlying mechanisms increased risk.In this prospective cohort study, we examined hospitalization treatment an intensive care unit (ICU) COVID-19, death from for disorders. Associations were step by adjusted (1) sociodemographic/economic factors, (2) indicators virus exposure, (3) somatic conditions, (4)...

Background Poor academic performance in childhood is associated with suicide attempt adulthood, but the mechanisms are not known. We investigated educational attainment as a possible pathway. Methods followed two sets of cohorts, born around 1950/1970, respectively, Swedish population-representative ‘Evaluation Through Follow-up’ study for first national records up to 2013. Data on grade point average (GPA) at age 13/16 and (years schooling) adulthood were used. The path models included...

Background The association between childhood cognitive ability measured with IQ tests and mortality is well documented. However, studies on the in women are few conflicting, mechanisms underlying unclear. Methods Data were collected at school age 13 among 19 919 men born 1948 1953. Information socioeconomic position, participants’ social circumstances middle up to 2013 was through national registers. Results Lower associated an increased risk of all-cause (1070 cases, HR 1.31, 95% CI 1.23...

Abstract Background Cognitive ability and socioeconomic background (SEB) have been previously identified as determinants of achieved level education. According to a “discrimination hypothesis”, higher cognitive is required from those with lower SEB in order achieve the same education SEB. Support for this hypothesis has claimed observation positive association between when adjusting ability. We propose competing that observed due residual confounding. Methods To adjudicate discrimination...

Abstract Objective To investigate whether patients with clozapine treatment are at an increased risk of a more severe COVID‐19 infection as compared on other antipsychotic drugs. Methods In this register‐based cohort study, all residents (age 18 or older) in the Stockholm Region psychotic disorder diagnosis and were included ( N = 8 233) followed from 1 March 2020 to 14 January 2021. The exposure was defined outcome measures (indicating infection) were: inpatient care, care within intensive...

The COVID-19 pandemic is commonly believed to have increased common mental disorders (CMD, i.e., depression and anxiety), either directly due contractions (death of near ones or residual conditions), indirectly by increasing stress, economic uncertainty, disruptions in daily life resulting from containment measure. Whereas studies reporting on initial changes self-reported data frequently reported increases CMD, related CMD primary care utilization are less well known. Analyzing time series...

Abstract Background Characteristics of the neighbourhood environment, including population density, social fragmentation, and trust, have been linked to mental health outcomes. Using a longitudinal population-based cohort, we explored relationship between objective subjective characteristics odds suicidal thoughts attempts. Methods We conducted study 20764 participants living in Stockholm County who participated Public Health Survey. used multilevel modelling examine if attempts were...

Throughout the industrialized world, demand for low skilled labour is falling. The length of schooling increasing in response, but so proportion individuals not finishing upper secondary school. objective this study was to evaluate associations between market positions at age 18 and all-cause suicide- accident-specific mortality later adulthood.Labour were categorized all Swedes born 1972-77 (n=630 959) into four main groups: employed, successful students, students about qualify (SNAQs),...

Previous studies suggest a protective effect of parenthood on suicide, but little is known about how the association may change across lifespan, or in relation to sex, marital status occurrence psychiatric disorders.We followed cohort over 5 million Swedish women and men, from 1991 2011, up max. age 75, for death by suicide using national registers. Information childbirths/adoptions, potential confounders modifying factors were obtained We assessed associations between adulthood within...

Lower intelligence early in life is associated with increased risks for coronary heart disease (CHD) and mortality. Intelligence level might affect compliance to treatment but its prognostic importance patients CHD unknown.A cohort of 1923 Swedish men a measure from mandatory military conscription 1969-1970 at age 18-20, who were diagnosed 1991-2007, followed the end 2008.recurrent event. Secondary outcome: case fatality first event, cardiovascular all-cause National registers provided...