Introduction Every industry has greenhouse gas emissions, with healthcare a significant contributor. In Canada, the sector is directly and indirectly responsible for 4.6% of country's emissions. Operating rooms (ORs) are major contributors to hospital waste, making OR low hanging fruit analyzing environmental practices. The can adopt green mindset reduce its carbon footprint, yet barriers going exist. Herein we study non-hospital surgical centres in British Columbia assess current practices,...

Post-translational modifications of proteins (including phosphorylation, acetylation and methylation, among others) frequently carry out their biological functions by serving as 'on' switches for protein–protein interactions. As highly localized perfectly defined hot-spots binding, they are a diverse set motifs that collectively offer great promise targets therapeutic intervention fundamental studies chemical biology. Recent years have seen the discovery very large number such modification...

Tetrazoles and acyl sulfonamides are functional groups that common in medicinal chemistry but virtually unexplored as recognition elements supramolecular chemistry. We report here on the anion binding properties of these highly acidic N-H groups. have prepared two new calixarene-based tetrazole-containing hosts, well acetyl sulfonamide benzoyl hosts. also analogous hosts bearing better-known aryl group a point comparison. find competent binders anions by is dependent their conformational...

Percutaneous sclerotherapy is the preferred method of treatment for VMs (venous malformations). However, protocols vary, and research on most effective sclerosant conflicting. Additionally, there limited knowledge effect volume outcome. This study aims to determine outcomes complications image-guided with respect volume. Towards this, a 10-year retrospective chart review was conducted patients treated at Vascular Anomalies Clinic British Columbia Children's Hospital. Thirty-four were which...

We report a novel pyrrolo-tetrazole motif that encodes anion binding orders of magnitude stronger than closely related systems and suggests the general utility amide-tetrazole exchanges for creating simple, high-affinity binders.

The factors determining diastereoselectivity observed in the multicomponent conversion of amino acids, aziridine aldehyde dimers, and isocyanides into chiral piperazinones have been investigated. Amino acid-dependent selectivity for either trans- or cis-substituted piperazinone products has achieved. An experimentally determined model three-component reaction driven by dimers predictive value different substrate classes. Moreover, this is useful reconciling previously reported observations...

Purpose: Herein, the authors aim to describe their findings of novel architectural types lymphatic malformations (LM) and explain relationship between these architectures OK-432 treatment outcomes. Methods: A retrospective review was conducted all patients diagnosed with a LM treated at Vascular Anomalies Clinic BC Children's Hospital from December 2002 January 2012. Results: Twenty-seven were included in study. Sixty percent lesions present by 2 years age majority located head neck (59%)....

Purpose: Prior literature has described the perspectives of parents young children with clip lip and/or palate; however, few studies have parents’ experiences within a Canadian health care system. This study aims to better understand cleft palate seen at tertiary center and identify their needs. Design: In-depth semistructured interviews. Setting: Pediatric center. Participants: Parents younger than 7 years age palate. Results: From 14 interviews, 4 themes were identified. The diagnosis...

Background: Our group previously developed an upper extremity repositioning (Sup-ER) protocol for brachial plexus birth injuries (BPBIs) that may improve supination and external rotation (ER) at 2 years of age. Questions were raised about the potential to cause internal (IR) deficits. The goal this study was explore longer-term outcomes Sup-ER investigate IR/ER function. Methods: This prospective cross-sectional cohort examined 16 children older than 4 age with significant enough BPBI be...

Objective: Determine what parents of children with cleft lip and palate value in online educational videos evaluate whether their needs are currently being met. Design: Focus groups telephone interviews were used to define parent information needs, followed by an evaluation available YouTube meet these needs. Setting: British Columbia Children’s Hospital multidisciplinary clinic. Participants: Twenty-four nonsyndromic palate. Results: Parents desired that accessible, trustworthy, relatable,...

This study aimed to describe the social determinants of health (SDoH) for patients receiving multidisciplinary team care in a Cleft Palate-Craniofacial program, develop responsive and consistent processes include trauma-informed psychosocial histories, promote discussions about additional “non-medical” factors influencing surgical outcomes, demonstrate that these activities are feasible context patient-provider interactions. Single-site, cross-sectional using questionnaire. Participants were...

A 2016 review of the BC Children's Hospital Cleft Palate - Craniofacial Program (CPP) revealed that one-third patients met program's care recommendations and half American Palate-Craniofacial Association guidelines. This study reviews on CPP waitlist determines median wait times missed clinical assessments as well identifies how are influenced by medical complexity, specialized speech service needs, vulnerability, distance from clinic.Cross-sectional.BC Program.Five hundred seventy-six...

Objective: To characterize current Cleft Palate Program (CPP) practices and evaluate the timeliness of appointments with respect to patient age diagnosis based on American Palate-Craniofacial Association (ACPA) population guidelines CPP patient-specific recommendations. Design: A retrospective review from November 6, 2012, March 31, 2015, was done. Data were analyzed using descriptive inferential statistics. Setting: The study conducted data at BC Children’s Hospital. Patients: total 1214...

Background: For children with upper brachial plexus birth injury (BPBI; C5, C6, ±C7 roots), most clinics first recommend nonsurgical treatment followed by primary and/or secondary surgical interventions in selected patients. Since 2008, we have used an infant shoulder repositioning protocol (supination-external rotation [Sup-ER]) designed to prevent internal contracture and its potential effects on the joint. This study characterizes our clinic’s current choice, number, timing of procedural...

Acticoat™ is a silver nanoparticle burn and wound dressing. Following use they are sent to the landfill where leaching into environment can occur. Although toxic effects of known, no study has calculated amount remaining in used dressings. Herein we quantify relative unused dressings establish need for recycling initiatives. obtained from British Columbia Children's Hospital were sampled an acid digestion extract was optimized performed. The concentration measured by atomic absorption...

Background Social determinants of health (SDoH) influence overall health, although little is known about the SDoH for pediatric patients requiring surgical services. This study aims to describe attending out-patient and community outreach clinics, as well demonstrate feasibility identifying addressing Adverse Childhood Experiences (ACEs) when appropriate. Methods A cross-sectional using surveys evaluating that were distributed families clinics over a two-year period. The pilot survey used...

Background: Brachial plexus birth injuries (BPBIs) can often result in functional and cosmetic deficits including, according to a recent scoping review, elbow flexion contractures up 48%. A treatment algorithm that includes custom long-arm orthosis optimize early glenohumeral joint positioning (Sup-ER protocol) has been shown improve shoulder range of motion. Although the protocol was not intentionally designed affect elbow, this study investigates prevalence severity children treated with...

Patient-reported outcome measures (PROMs) are increasingly used to seek feedback from patients. Knowledge gaps exist regarding outcomes in adolescents postgynecomastia surgery. This study assesses adolescent patients' quality of life surgery using a PROM specific for body contouring procedures, and identifies patient treatment factors associated with scores.

As scientific publishing has transitioned online, open access and predatory publishers have surged. This study describes the frequency of publications in potentially journals among applicants to a Canadian plastic surgery residency program, explores applicant characteristics associated with publishing.

Abstract Background Social determinants of health (SDoH)—which are factors such as socioeconomic status (SES), access to transportation, food and housing security, disability social supports—have been shown influence up 50% in patients. The project team developed a SDoH Questionnaire which evolved into what is now referred BEARS (Barriers Care, Economic Factors, Adversity, Resiliency, Capital). Part the includes an optional section for inquiring about Adverse Childhood Experiences (ACEs)....