A5100415768- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Cardiac and Coronary Surgery Techniques
- PI3K/AKT/mTOR signaling in cancer
- Aortic Disease and Treatment Approaches
- Proteoglycans and glycosaminoglycans research
- Congenital heart defects research
- Protein Kinase Regulation and GTPase Signaling
- Mitochondrial Function and Pathology
- Silk-based biomaterials and applications
Shanghai Children's Medical Center
2017-2023
Shanghai Jiao Tong University
2020-2023
Electrospun hybrid nanofibers prepared using combinations of natural and synthetic polymers have been widely investigated in cardiovascular tissue engineering. In this study, electrospun gelatin/polycaprolactone (PCL) collagen/poly(l-lactic acid-co-ε-caprolactone) (PLCL) scaffolds were successfully produced. Scanning electron micrographs showed that fibers both membranes smooth homogeneous. Water contact angle measurements further demonstrated hydrophilic. To determine cell attachment...
Tissue engineered vascular grafts (TEVGs) with diameters <6 mm have broad applications. However, maintaining graft post-implantation patency and function is still difficult to achieve of urgent necessity. In this study, we use an effective strategy make the large-pore electrospun polycaprolactone (PCL) cotton material (Cotton) utilized immunoreactive pre-cultivation prepare a small diameter autologous TEVG. The assessment via scanning electron microscopy revealed that Cotton has favorable...
Background Postnatal human cardiomyocyte proliferation declines rapidly with age, which has been suggested to be correlated increases in oxidative DNA damage mice and plays an important role regulating proliferation. However, the relationship between age humans is unclear. Methods Sixty right ventricular outflow myocardial tissue specimens were obtained from septal defect infant patients during routine congenital cardiac surgery. These divided into three groups based on age: group A (age 0–6...
Abstract The Rho family plays crucial roles in O 2 ‐induced vasoconstriction, cell proliferation, and migration. GTPase‐activating protein 26 (ARHGAP26) is a for the small GTPases of family. Our previous studies have demonstrated that ARHGAP26 expression was significantly downregulated patent human ductus arteriosus (DA) tissue. However, its role underlying maintenance DA patency unclear. In this study, (fetal) constricted (newborn) mouse tissues were harvested to confirm differences levels...
There is an urgent need to design a tissue-engineered vascular graft that exhibits good biocompatibility and sufficient mechanical strength repair facilitate regeneration of defective tissue. It generally accepted multi-layer stents can be used simulate the structure function natural blood vessels. Here, we developed new three-layer tubular rolled from single Poly(L-lactide-co-caprolactone) electrospun membrane. We electrospinning technique place three different structures on membrane such...