A5010483106- Meningioma and schwannoma management
- Pituitary Gland Disorders and Treatments
- Glioma Diagnosis and Treatment
- Neurological disorders and treatments
- Head and Neck Surgical Oncology
- Functional Brain Connectivity Studies
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- Ion channel regulation and function
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Cerebrospinal fluid and hydrocephalus
- Medical Image Segmentation Techniques
- Brain Metastases and Treatment
- Ophthalmology and Eye Disorders
- Pharmacological Effects and Toxicity Studies
- Neurofibromatosis and Schwannoma Cases
- Chromatin Remodeling and Cancer
- Sinusitis and nasal conditions
- Bone Tumor Diagnosis and Treatments
- Tumors and Oncological Cases
- Neuroscience and Neural Engineering
- Surgical Simulation and Training
- Vascular Malformations Diagnosis and Treatment
University of Calgary
2015-2025
Foothills Medical Centre
2015-2022
Alberta Bible College
2019
Montreal Neurological Institute and Hospital
2018
Novartis (Canada)
2018
Oxford University Press (United Kingdom)
2018
Libin Cardiovascular Institute of Alberta
2015
Allen Institute for Brain Science
2015
Alexandria University
2014
Grand Valley State University
2014
T-type (CaV3.1/CaV3.2) Ca(2+) channels are expressed in rat cerebral arterial smooth muscle. Although present, their functional significance remains uncertain with findings pointing to a variety of roles.This study tested whether CaV3.2 mediate negative feedback response by triggering sparks, discrete events that initiate hyperpolarization activating large-conductance Ca(2+)-activated K(+) channels.Micromolar Ni(2+), an agent selectively blocks but not CaV1.2/CaV3.1, was first shown...
We present a method of constructing database intraoperatively observed human subcortical electrophysiology. In this approach, patient electrophysiological data are standardized using multiparameter coding system, annotated to their respective magnetic resonance images (MRIs), and nonlinearly registered high-resolution MRI reference brain. Once registered, we able demonstrate clustering like interpatient physiologic responses within the thalamus, globus pallidus, subthalamic nucleus, adjacent...
Abstract Background Despite extensive and persistent activation of microglia in multiple sclerosis (MS), inhibitors have not yet been identified for treatment the disorder. We sought to identify medications already clinical use that could inhibit microglia. On basis reported inhibitory effects dipyridamole on phosphodiesterase activity result production various anti-inflammatory outcomes, we selected it study. Dipyridamole is used clinically secondary prevention stroke. In this study, was...
The regulation of arterial tone is critical in the spatial and temporal control cerebral blood flow. Voltage-gated Ca2+ (CaV) channels are key regulators excitation–contraction coupling smooth muscle, thereby tone. Although L- T-type CaV have been identified rodent little known about expression function specific subtypes human arteries. Here, we determined which present arteries defined their roles determining Quantitative polymerase chain reaction Western blot analysis, respectively, mRNA...
Abstract Background Postoperative stereotactic radiosurgery (SRS) is a standard management option for patients with resected brain metastases. Preoperative SRS may have certain advantages compared to postoperative SRS, including less uncertainty in delineation of the intact tumor resection cavity, reduced rate leptomeningeal dissemination postoperatively, and lower risk radiation necrosis. The recently published ASCO-SNO-ASTRO consensus statement provides no recommendation preferred...
To evaluate the cost-effectiveness of an endoscopic versus microscopic approach to pituitary adenoma resection.Markov decision tree economic evaluation.An evaluation using a Markov model was performed. The perspective that healthcare third-party payer. Effectiveness and probability data were obtained from single meta-analysis 38 studies. Costs Healthcare Cost Utilization Project database wholesale pharmaceutical pricing. Multiple sensitivity analyses performed including probabilistic...
No validated tools exist to assess satisfaction with epilepsy surgery. We aimed develop and validate a new measure of patient surgery, the 19-item Epilepsy Surgery Satisfaction Questionnaire (ESSQ-19).An initial 31-item was developed based on literature review, focus groups, thematic analysis, Delphi panels. The questionnaire administered twice, 4-6 weeks apart, 229 adults (≥18 years old) who underwent surgery ≥1 year earlier, at three centers in Canada one Sweden. Participants also...
ABSTRACT Objective The 19‐item Epilepsy Surgery Satisfaction Questionnaire (ESSQ‐19) is a validated and reliable post hoc means of assessing patient satisfaction with epilepsy surgery. Prediction models building on these data can be used to counsel patients. Methods ESSQ‐19 was derived 229 patients recruited from Canada Sweden. We isolated 201 (88%) complete clinical for this analysis. These were adults (≥18 years old) who underwent surgery 1 year or more prior answering the questionnaire....
ABSTRACT Background: To evaluate clinical outcomes and volumetric changes following endoscopic endonasal approach (EEA) for tuberculum sellae (TS) planum sphenoidale (PS) meningiomas. Key objectives included evaluating pre- postoperative tumor volumes, visual assessments EEA-related complications. Methods: A single-center retrospective study was conducted at Foothills Medical Centre, University of Calgary, Canada, from 2009 to 2022 including 24 patients meeting inclusion criteria midline...
Introduction: Visual dysfunction is one of the primary indications for surgical management pituitary tumors with goal terminating progressive decline in vision. Unfortunately, it difficult to predict how successful decompression will be these patients. The purpose this study was assess structural changes seen anterior visual pathway after tumor resection. Methods: 13 patients (7F) underwent endoscopic resection macroadenoma. Each patient a full ophthalmologic assessment including optical...
Epilepsy surgery is offered in resistant focal epilepsy. Non-invasive investigations like scalp video EEG monitoring (SVEM) help delineate epileptogenic zone. Complex cases may require intracranial (IVEM). Stereoelectroencephalography (SEEG)-based intracerebral electrode implantation has better spatial resolution, lower morbidity, tolerance, and superiority sampling deep structures. Our objectives were to assess IVEM using SEEG with regard reasoning behind implantation, course, surgical...
We present a young adult woman who developed myxoid tumor of the pineal region having SMARCB1 mutation, which was phenotypically similar to recently described desmoplastic myxoid, SMARCB1-mutant (DMT-SMARCB1). The 24-year-old presented with headaches, nausea, and emesis. Neuroimaging identified hypodense lesion in CT scans that T1-hypointense, hyperintense both T2-weighted FLAIR MRI scans, displayed gadolinium enhancement. resected had an abundant, Alcian-blue positive matrix interspersed,...
This work presents methodologies for assessing the accuracy of non-rigid intersubject registration algorithms from both qualitative and quantitative perspectives. The first method was based on a set 43 anatomical landmarks. MRI brain images 12 subjects were non-rigidly registered to standard dataset. "gold-standard" coordinates landmarks in target estimated by averaging their after 6 tagging sessions. Euclidean distance between each landmark subject warping reference space homologous image...
We report the first example of an anaplastic meningioma arising from intracranial arachnoid cyst and discuss diagnostic challenges this case, including useful role genetic markers.A 72-year-old man presented with transient episodes expressive dysphasia focal motor seizures, superimposed on a 6-month history worsening headaches dizziness. His past was significant for previously drained left-sided chronic subdural hematoma radiologically diagnosed left middle fossa cyst. Magnetic resonance...
Initial descriptions of endoscopic approaches to the sella and pituitary involved resecting middle turbinate (MT) help improve access visualization. Modifications these procedures preserve MT have since been described, one rationale being reduce incidence frontal sinusitis. The objective this study was establish postoperative sinusitis in sparing (MTsp) sacrificing (MTsc) sella.A retrospective cohort that compared radiographic evidence rhinosinusitis or recess obstruction after skull base...
Abstract Objective We aimed to assess the reliability and validity of single‐item global ratings (GR) satisfaction with epilepsy surgery. Methods recruited 240 patients from four centers in Canada Sweden who underwent surgery ≥1 year earlier. Participants completed a validated questionnaire on (the ESSQ‐19), plus GR twice, 4–6 weeks apart. They also questionnaires quality life, depression, health state utilities, severity disability, medical treatment social desirability. Test‐retest was...