A5009327105- Circadian rhythm and melatonin
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Developmental Biology and Gene Regulation
- Cancer-related molecular mechanisms research
- Hearing, Cochlea, Tinnitus, Genetics
- Spaceflight effects on biology
- Vascular Malformations Diagnosis and Treatment
- Electromagnetic Fields and Biological Effects
- Nosocomial Infections in ICU
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Central Venous Catheters and Hemodialysis
- Cerebrovascular and Carotid Artery Diseases
- Immune Cell Function and Interaction
- Paranormal Experiences and Beliefs
- Immune cells in cancer
- Extracellular vesicles in disease
- Burkholderia infections and melioidosis
- Salivary Gland Disorders and Functions
- Education and Work Dynamics
- Tuberculosis Research and Epidemiology
- Inflammation biomarkers and pathways
- Photoreceptor and optogenetics research
- Ideological and Political Education
Peking University
2008-2024
National Clinical Research Center for Digestive Diseases
2016-2023
First Hospital of Shanxi Medical University
2012-2019
Shanxi Medical University
2012-2019
University of Pennsylvania
2005-2018
Tianjin Medical University Cancer Institute and Hospital
2015-2016
Inserm
2014
Children's Hospital of Philadelphia
2014
Sorbonne Paris Cité
2014
Université Paris Cité
2014
Sensorineural deafness and balance dysfunction are common impairments in humans frequently caused by defects the sensory epithelium of inner ear, composed hair cells supporting cells. Lineage studies have shown that arise from a progenitor, but how these progenitors generated remains unknown. Although various molecules been implicated development progenitors, none has to be required for specification mammalian ear. Here, using both loss-of-function gain-of-function approaches, we show...
Hearing impairment or vestibular dysfunction in humans often results from a permanent loss of critical cell types the sensory regions inner ear, including hair cells, supporting cochleovestibular neurons. These important arise common neurosensory progenitor, although little is known about how these progenitors are specified. Studies have shown that Notch signaling and transcription factor Sox2 required for development lineages. Previously we others demonstrated ectopic activation can direct...
Rationale With the amounts and types of new psychoactive substances (NPSs) increasing rapidly in recent years, an excellent high‐throughput method for analysis these compounds is urgently needed. In this article, a rapid screening quantitative 11 NPSs are described compared, respectively. Method A simple direct real time mass spectrometry (DART‐MS) was developed including three categories present on global market such as four cathinones, one phenylethylamine, six synthetic cannabinoids....
Sjögren's syndrome (SS) is an autoimmune disorder characterized by sicca and/or systemic manifestations. The treatment still challenging. This study aimed to explore the therapeutic role and mechanism of exosomes obtained from supernatant stem cells derived human exfoliated deciduous teeth (SHED-exos) in sialadenitis caused SS.SHED-exos were administered submandibular glands (SMGs) 14-week-old non-obese diabetic (NOD) mice, animal model clinical phase SS, local injection or intraductal...
The Heart of Glass (HEG) receptor binds KRIT1 and functions with KRIT1, CCM2, PDCD10 in a common signaling pathway required for heart vascular development. Mutations also underlie human cerebral cavernous malformation (CCM) postnatal loss these genes the mouse endothelium results rapid CCM formation. Here, we test role HEG formation mice humans.We constitutively or conditionally deleted Heg Ccm2 genetically modified mice. Mouse embryos, brain, retina tissues were analyzed to assess lesion...
Purpose To determine whether activated Notch can promote a supporting cell fate during sensory differentiation in the inner ear. Methods An form of Notch1 receptor (NICD) was expressed early differentiating hair cells using Gfi1-Cre mouse allele. effects on developing cells, Gfi1-NICD animals and their littermate controls were assessed at 5 weeks for hearing by measuring auditory brainstem responses (ABRs) distortion product otoacoustic emissions (DPOAEs). The NICD-expressing postnatal day...