A5036917069- Oral microbiology and periodontitis research
- Endodontics and Root Canal Treatments
- Mesenchymal stem cell research
- Dental Radiography and Imaging
- Toxin Mechanisms and Immunotoxins
- Urinary Tract Infections Management
- Infective Endocarditis Diagnosis and Management
- Electrospun Nanofibers in Biomedical Applications
- vaccines and immunoinformatics approaches
- Antibiotic Use and Resistance
- Tissue Engineering and Regenerative Medicine
- Nuclear Receptors and Signaling
- Vector-borne infectious diseases
- Bioactive Compounds and Antitumor Agents
- Biochemical Acid Research Studies
- Plant and soil sciences
- Immunotherapy and Immune Responses
- Antioxidant Activity and Oxidative Stress
- Cholinesterase and Neurodegenerative Diseases
- Tryptophan and brain disorders
- SARS-CoV-2 and COVID-19 Research
- Polymer Synthesis and Characterization
- Endoplasmic Reticulum Stress and Disease
- Gut microbiota and health
- RNA Interference and Gene Delivery
Autonomous University of Queretaro
2018-2025
Hospital General Universitario de Ciudad Real
2016-2024
Universidad Nacional Autónoma de México
2012-2016
ABSTRACT How could quercetin exert a pro‐survival phenotype (antioxidant) and simultaneously be toxic for eukaryotic cells? The redox capacity of may explain its antioxidant effects, based on the idea that impairs electron transport chain, affecting ATP production forming quercetin‐derived free radicals. Herein, we provide evidence supplementation: (1) depolarizes mitochondrial membrane augments ADP/ATP ratio; (2) increases superoxide anion cellular levels; (3) changes response to H 2 O...
This investigation aimed to detect coincidences in the antimicrobial resistance genes (ARG) profiles between members of a group living household and compare them other groups order establish if an exchange ARG occurs dental plaque microbiota can be considered as source reservoir that shared humans pets. One hundred sixty samples were obtained from four groups: Shelter dogs (n=20), adult pet owners (AD group, n=40), owners, children (ACD n=60), non-pet (AC n=40). DNA was obtained, specific...
Cruciferous vegetables such as cauliflower and radish contain isothiocyanates exhibiting chemoprotective effects in vitro vivo. This research aimed to assess the impact of (CIE) (RIE) isothiocyanate extracts on metabolic activity, intracellular reactive oxygen species (ROS), LDH production selected human colorectal adenocarcinoma cells (HCT116 HT-29 for early late colon cancer development, respectively). Non-cancerous (CCD-33Co) were used a cytotoxicity control. The CIE samples displayed...
The aim of this work was to evaluate the effect PPAR agonists on differentiation and metabolic features porcine mesenchymal stem cells induced adipogenic or myogenic lineages.Bone marrow MSCs from neonate pigs were isolated identified by cell proliferation, surface markers gene expression (CD44, CD90, CD105 Oct4 Nanog, respectively). Cells differentiated into adipose muscle treated with agonists; promoted adding these compounds. PPARγ (an marker) MyoD1 MyHC (muscle markers), changes levels...
This research aimed to explore the anti-inflammatory properties of two different aqueous extracts from Mexican Castor bean leaves accessions (R1 and R2) in lipopolysaccharide (LPS)-challenged murine RAW 264.7 cells. Two (S1 S2) grown Amazcala (Mexico) were washed, sun-dried (35–60 °C), ground, screened (250 mm particle size). Aqueous prepared by dissolving 100 mg powders 10 mL distilled water maintained a bath (40 °C) under stirring for 1 h. Samples then centrifuged (3500 g, 15 min, 4 °C)....
It has been proposed that oral commensal bacteria are potential reservoirs of a wide variety antimicrobial resistance genes (ARGs) and could be the source pathogenic bacteria; however, there is scarce information regarding this. In this study, three common streptococci mitis group (S. oralis, S. sanguinis, gordonii) isolated from dental plaque (DP) were screened to identify if they frequent specific ARGs (blaTEM, cfxA, tetM, tetW, tetQ, ermA, ermB, ermC). DP samples collected 80 adults; one...
Antimicrobial resistance is a global public health problem. Root canal microbiota associated with apical periodontitis represents well-known reservoir of antimicrobial genes (ARGs). However, the effect type 2 diabetes mellitus (T2DM) in this unknown. This study aimed to establish if root T2DM patients an augmented by identifying prevalence nine common ARGs and comparing it nondiabetic patients. Methodology cross-sectional included two groups: A group conformed 20 at least ten years living...
Neurotoxic lesion of the pedunculopontine nucleus (PPN) is known to cause subtle motor dysfunctions. However, coordination during advance on a discontinuous and elevated surface has not been studied. It also whether there are changes in mRNA expression nuclear factor (erythroid-derived 2)-like 2 (Nrf2) nigral tissue.The effects unilateral neurotoxic PPN evaluated through grid test Nrf2 tissue were evaluated. Two experimental designs (ED) organized: ED#1 behavioral study (7 30 days after...
Abstract Objective To monitor the gut colonization by multidrug resistant (MDR) bacteria in residents of a single long-term care facility (LTCF) relation to their clinical evolution, antibiotic consumption and mortality risk. Methods In total 187 voluntarily enrolled residents, five rectal swabs samples were recovered over 1 year. Selective media used isolate MDR bacteria. Clinical data related infections, recovered. Mortality risk among who colonized non-colonized was compared Kaplan–Meier...
Endodontic freshly mixed sealers display toxic effects; however, these are significantly reduced and most become relatively inert in the set state but there is no information about possible inflammatory reaction promoted by them. Four contemporary different formulated endodontic (MTA Fillapex, BioRoot RCS, AH Plus, Pulp Canal Sealer) were evaluated. Human periodontal ligament cells human peripheral blood mononuclear stimulated for 3, 6, 12 24 h. Interleukin-6, tumour necrosis factor-alpha,...
SARS-CoV-2 (Betacoronavirus pandemicum) is responsible for the disease identified by World Health Organization (WHO) as COVID-19. We designed “CHIVAX 2.1”, a multi-epitope vaccine, containing ten immunogenic peptides with conserved B-cell and T-cell epitopes in receceptor binding domain (RBD) sequences of different variants concern (VoCs). evaluated immune response mice immunized 20 or 60 µg chimeric protein two alum adjuvants (Alhydrogel® Adju-Phos®), plus PHAD®, two-immunization regimen (0...
Background and Objectives: The knowledge that the cholinergic neurons from pedunculopontine nucleus (PPN) are vulnerable to degeneration in early stages of Parkinson disease progression has opened new perspectives development experimental model focused pontine lesions could increase risk nigral degeneration. In this context it is known PPN lesioned rats exhibit changes gene expression proteins responsible for dopaminergic homeostasis. At same time, nicotinic receptors (nAChRs) mediate...
<h3>Background</h3> In April 2015, a national project was created to reduce the rate of patients with nosocomial infections by multiresistant bacterias (MRBs). This had several recommendations, including ones for improving use antibiotics, especially against MRBs. <h3>Purpose</h3> To analyse impact on consumption antibiotics in our intensive care unit (ICU) during first months after initiation project; and also assess its economic number colonised/infected <i>Acinetobacter baumannii</i>...
Theoretically, a necrotic root canal fulfils all requirements as niche for methanogens to inhabit. However, their presence in it and its implication apical periodontitis (AP) is controversial. Therefore, contribute ending the controversy, this study aimed detect compare methanogens' two distinct niches with supposedly different microenvironments; both were canals associated AP but one from patients type 2 diabetes mellitus (T2DM) while other non-diabetic patients. A clinical examination was...